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Re: Whole genome sequencing for $700-750?
@Ul Looks like its $99 now, and $199 normally, which is a great price. Looks like they want to really start finding out what the genome does, but I think they'd need detailed medical history to be…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
General Discussion
Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC stomach upset is likely just side effect of the pills, you need better biomarkers to test for senolytic effects. I'm putting a list up in a WIKI here in the near future.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Self-Experimentation
Reported - view
Re: Fasting IGF1/autophagy and more
@Deb63 “Dry fasting”? No water? If so I really wouldn’t recommend that, there’s no benefit and many downsides. When I first started fasting years ago I wasn’t careful with my water intake and became…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
General Discussion
Reported - view
Re: Fasting IGF1/autophagy and more
I should also mention, if you really don't want to fast you can get much of the benefits by doing the Fasting Mimicking Diet, and you don't even have to cook FMD Pricing
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
General Discussion
Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM Pretty sure this hasn't been studied so nobody knows. A 5 day water fast is what really kicks in the autophagy - more powerful than fisetin by itself FWIW.
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
Self-Experimentation
Reported - view
Fasting IGF1/autophagy and more
Worth watching. From the video In both mice and humans, fasting for 2 or 5 days respectively, causes ... 50% decrease in IGF-1 30% or more decrease in glucose 5-10 fold increase in IGF-1 binding…
Dan
moderator
skipping my funeral
dantheman
updated
5 yrs ago
12
replies
285
1
General Discussion
Re: Need more emphasis on diet
Your approach sounds exactly like what we do in my household. Fuhrman diet primarily (whole food plant based) - no animal products, but occasional extras like a bit of sourdough bread.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
General Discussion
Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo @JGC Yes that's the correct quote in this context I believe. In simple terms they found the coefficients from a model fit (the model has many inputs and from a large sample set),…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Assessing Biological Age
Reported - view
Re: Is Young Plasma Really a Worthwhile Treatment for Aging?
Taking a step back - what is the purpose of blood? Mainly to transport stuff around the body. In itself it serves little purpose AFAIK, unlike say the liver which performs many complex tasks…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
General Discussion
Reported - view
Re: Is Young Plasma Really a Worthwhile Treatment for Aging?
FWIW my small opinion is that I'm skeptical of the young plasma treatment. One, because it's difficult and expensive. Two, because it seems so obvious.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
General Discussion
Reported - view
Re: Using chelation for cardiovascular health
@Jay Galambos Thanks for the update. Have you made any other dietary changes? Reason I ask is because the only clinically validated way we have of clearing blockage (short of an operation) is…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
Self-Experimentation
Reported - view
Re: DNA methylation test
@albedo No I don't know what exactly they're testing, here is what they say The myDNAge® Epigenetic Aging Clock service is based on Steve Horvath’s aging clock and utilizes SWARM™ (Simplified…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Assessing Biological Age
Reported - view
Re: DNA methylation test
@albedo No problem, but no I haven't gotten it yet. Takes a number of weeks, plus we have the holidays. Thanks for the kind words otherwise.
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
Assessing Biological Age
Reported - view
What type of physician do you have?
Can't post polls but am curious about what type of physician(s) are you working with? Ideally I'd have a concierge physician, but they require a $2k yearly retainer (one example).…
Dan
moderator
skipping my funeral
dantheman
updated
5 yrs ago
1
reply
75
General Discussion
12 people in hospitals after stem cell treatment
Infections put 12 people in hospitals after they received unapproved stem cell products Twelve people in three states developed infections and were hospitalized after they got infusions or…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
4
replies
536
Mesenchymal Stem Cells
Re: Metformin in practice
@JGC Thanks for your details. I went to my primary and they didn't see anything on an EKG but are referring to cardio to make sure. Which is fine, it's on my list to do a through heart check.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
General Discussion
Reported - view
Re: Bizarre that I can't pay for an order from the site
<not getting into a political discussion I hate politics and for the record am independent> but since it's relevant, since the present U.S. administration is so bent on dismantling government,…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
Self-Experimentation
Reported - view
Metformin in practice
I started Metformin with Rx (due to genetic defects for glucose and glucose control that is no longer optimal - plus the aging benefits) according to the Life Extension protocol.…
Dan
moderator
skipping my funeral
dantheman
updated
5 yrs ago
24
replies
804
1
General Discussion
Re: Compounding pharmacy sources for Dasatinib and quercetin
@Birgit Thorwald Yes he said that the patches were as effective.
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
Questions & Answers
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@adonoho I think we also agree here. Taking your Type 2 example, yes it's both genetic and lifestyle. I have several defects for high fasting glucose, which by my 20's resulted in terrible health…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
3
Self-Experimentation
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@adonoho Yes we practice time restricted feeding, thanks. FWIW I don't support the ketogenic diet approach, it seems clear to me that intermittent ketosis via periodic fasting works,…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Self-Experimentation
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@adonoho said: As a result, I think we see "diseases", such as senolytic cell accumulation, that our body could not afford to tolerate in earlier ages.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
Self-Experimentation
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@albedo Yeah that young.ai site has coming all sorts of markers - pictures (work has been done by networks figuring age from a face photo), oh I forget but a bunch of stuff.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
1
Self-Experimentation
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
Well there might be one test, I don't know if anybody has looked at this (note I'm a physicist/engineer/musician/composer, not a biologist!) which is using the Ames test for broken DNA in the urine.…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Self-Experimentation
Reported - view
Re: "Senolytic Activator" and Extended Fasting …
@BobM Senescent cells are recycled, your body literally reuses the golgi and other parts. The only way to measure senescence that I know is by taking a tissue sample and using dye to visually see…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
2
Self-Experimentation
Reported - view
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