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Re: blood work @Michael https://www.cnbc.com/2020/10/03/how-star-trek-star-george-takei-stays-healthy-and-working.html "Eighty-three-year-old George Takei, is quite fit. He bangs on his taught midsection.…
- MAC
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: blood work @Michael With you brother. Ditch the smokes, very moderate drinking (red wine if you can tilt), whole foods diet. Load up on vitamin D. Sounds like your lean and fit and are far away from metabolic…
- MAC
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: blood work @Michael d Cardiorespiratory fitness is the ONLY proven lifespan extension proven in humans. Anyone who tells you to stop exercising is very ill informed on fitness/pro longevity research.…
- MAC
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Azithromycin kill/eliminate 97% senescent cells You're worried about antibiotics when you smoke, drink, and eat ice cream late at night? LOL
- MAC
- MAC
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: blood work Not sure if you're keto, depends on the % protein in your total calories...but you're so close to OMAD (one meal a day), make your food prep life easier, go for it! I am strict keto,…
- MAC
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: blood work Your weight and BMI? Blood pressure? Resting heart rate? Body fat? From a CVD point of view, your TG/HDL is <<2, which is excellent re atherogenic small LDL-P.…
- MAC
- MAC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Grey hair as a senescence detector? @Kathleen Klosterman Not sure either, but as an n=1, 55yo male, I started lifestyle longevity interventions 4 yrs ago (diet/exercise/meds), and although I have a few greys,…
- MAC
- MAC
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Dan Got my DNAage test result back. Reported DNAage of 52, I am 55; 85th percentile. I only started my "interventions" about 4yrs ago, so there's 51 years of previous lifestyle baked in.…
- MAC
- MAC
- 4 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Rapamycin self-experimentation @uzoma iwuagwu It's in the METHODS section: "At 3 months of age, mice were divided in two groups, one of them continued with control chow and the other were changed to chow-containing encapsulated…
- MAC
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin self-experimentation @Mark Thimineur A recent paper on Rapamycin and telomeres Rapamycin worsens diseases and premature aging in mice with short telomeres https://www.news-medical.…
- MAC
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin and APOE4 gene. @Randall James https://www.snpedia.com/index.php/Promethease I checked my Promothease report (from 23andme upload), it calls out specifically the two SNP's,…
- MAC
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin and APOE4 gene. @Jonathan Horwitz 23andme doesn't actually formally report...they give you the SNP alleles and you can confirm APOE status. Is that what you meant by your INVTAE post...…
- MAC
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin and APOE4 gene. I find the lab comment on termination of APOE reporting very odd. As of time of writing, APOE is still the #1 risk gene "associated" with risk of AD. Even though, depending on your ancestry,…
- MAC
- MAC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Rapamycin and APOE4 gene. You can follow someone who is Apoe4 and taking Rapamycin under the care of Dr Green on this forum for AD prevention: https://www.apoe4.info/forums/viewtopic.…
- MAC
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Good Metformin Research Paper to convince doctor Recent paper on Metformin as it relates to its effects on resistance exercise. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults:…
- MAC
- MAC
- 5 yrs ago
- General Discussion
- Reported - view
Re: The conventional CVD/lipid hypothesis: challenged I am not a doctor, cannot give you specific medical advice. I personally would exhaust all lifestyle interventions (cardio exercise #1 by far, diet with a heavy skew towards low glucose profile,…
- MAC
- MAC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
The conventional CVD/lipid hypothesis: challenged
The conventional mainstream lipid hypothesis suggests high cholesterol is directly associated with elevated CVD risk. High plasma cholesterol diffuses into the endothelial space via the LUMEN,…
- MAC
- MAC
- 5 yrs ago
- 2replies
- 72
- 1
- Self-Experimentation
Re: LDL-C reduction with diet and supplements (no statins) Here's a paper on all cause mortality and lipids re "lipids manipulation/targets" Association of lipoprotein levels with mortality in subjects aged 50 without previous diabetes or cardiovascular…
- MAC
- MAC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Phosphatidylcholine Here's a paper on choline/AD: Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation https://onlinelibrary.…
- MAC
- MAC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Metformin Recent review article on metformin. Metformin and Aging: A Review https://www.karger.com/Article/Pdf/502257 Questionable efficacy if one is very healthy, low glucose...especially if high exerciser.…
- MAC
- MAC
- 5 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin @Dan Some new literature on Rapamycin, including some new rapalogs that are HIGHLY specific to mTORC1! Its' the mTORC2 inhibition and impact on some of the "basic" biological functions such as…
- MAC
- MAC
- 5 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin @Staffan Olsson I practice BOTH in my daily routine, although I do resistance training more for skeletal muscle build, overall physical health, and strength/resiliency to help reduce risk of frailty…
- MAC
- MAC
- 5 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin Duy noted. My sleep hacking is still a work in progress. The melatonin (various doses) does not seem to impact my waking, although it definitely helps with falling asleep.…
- MAC
- MAC
- 5 yrs ago
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin @Dan we are all self-hackers, otherwise we wouldn't be on these forums! We cannot wait for western medicine to save us from chronic illness. I personally believe we must take responsibility for our…
- MAC
- MAC
- 5 yrs ago
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin @Dan my apologies if I offended you or anyone. I always try to stick the science as I see it, but always open to other interpretations.
- MAC
- MAC
- 5 yrs ago
- 1
- AMPK Activation
- Reported - view

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MAC

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