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Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? I am not certain of anything...sigh. But as an engineer, I have to instinctively go on the data. Am I stronger, fitter, low inflammation, no chronic disease or ailments, stellar biomarkers,…
- MAC
- MAC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? Mark, I agree this is the crux of the challenge...quantifying (hard scientific data) anti-aging benefit of our interventions? Forget all the mice studies and theories...…
- MAC
- MAC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Peter H. Howe I take daily 5ml of Carlson ELITE DHA/EPA liquid, which is 2920 total DHA/EPA (2270 DHA/430 EPA). You quote "centenarians"...that made my day!…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Peter H. Howe What type of EPA/DHA do you take? Yes, TG/HDL < 2, and closer to 1, is very anti-atherosclerotic...it's a surrogate for many things, especially LDL-P.…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Moshe M. I am strict ketgogenic, one meal a day...I am SUPER insulin sensitive. Ketones crush insulin. Most days I am hypoglycemic, my finger tips get numb!
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Moshe M. So what do you learn of interest with your CGM? I tried the Freestyle Libre for 14 days, didn't learn much as I'm strict ketogenic default. I was somewhat surprised that fats and proteins…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Peter H. Howe Free testosterone of 12-15 ng/dL is a good number, puts you in the range of a 25 yr old! Replacing plasma and such like interventions sound VERY promising indeed...…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Peter H. Howe Thanks Peter. No CVD, cholesterol or anemia issues. In fact, I started donating 500mL blood religiously every 8 weeks (free to donate here) 2 years ago for the express purpose of…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation @Peter H. Howe Hi Peter, seems like you've done a deep dive on Testosterone. I assume you believe it extends lifespan in males? Can I ask your age, and what does your doctor target for free…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Reversing Parkinson's disease with HGH One hit on pubmed, and not significant vs placebo. https://pubmed.ncbi.nlm.nih.gov/17469198/ HGH is pro-aging, so aside from apparently not impacting Parkinsons, it ages you.
- MAC
- MAC
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Rapamycin nasal spray for the brain? We all know full well the graveyard of amyloid busting mouse studies, and the failed scaling to humans. It's quite well agreed to (at least in my recent readings of the literature),…
- MAC
- MAC
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Rapamycin nasal spray for the brain? Thanks for sharing paper. This is all amazing science of course, moving our understanding of the complex dysfunctional brain forward. Couple of brief read high level comments.…
- MAC
- MAC
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse? @Curtis Smith Yeah I agree given the importance of attaching true anti-aging significance to relatively potentially very expensive, time consuming, and often significantly lifestyle infringing…
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse? @Curtis Smith more accurate? You want accuracy but low cost? There are other epigenetic clocks but Horvath is deemed the most accurate in humans. You should stick to one clock if you are going to…
- MAC
- MAC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse? @MAC I took a DNAge this past July. It uses the latest Horvath clock. https://www.mydnage.com/
- MAC
- MAC
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse? @Curtis Smith
- MAC
- MAC
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @Larry You said you did a DNAage test with URINE? I did one July 2020, it was a blood kit using latest Horvath clock. I am 55 yo, came back 52 (85th percentile).
- MAC
- MAC
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: Rapamycin and hgh I am currently only on DHEA/Testosterone, my FMD dosen't feel strongly about anything else currently. 55 yo male, excellent health/fitness, strict keto/OMAD.…
- MAC
- MAC
- 3 yrs ago
- General Discussion
- Reported - view
Re: DNA methylation test @Paul Bee I will have a look thanks Paul, I follow Josh's blog, fascinating, especially the comments. I am not looking for "saving", simply enhanced health-span/lifespan.…
- MAC
- MAC
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud while on the n=1 indications, most all of my peer group have significant grey hair, yet I have just have some threads at 55 yo. No one has undertaken the interventions I have.…
- MAC
- MAC
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud Yes my default is NO, unless otherwise swayed. I've not ventured into the water only/extended fasts. With my exercise regiment, I'd loose too much weight, then have to do big re-feeding,…
- MAC
- MAC
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud damn, was hoping you’d have some other compelling science pathway to convince me! I am interested in continuous health/lifespan improvement, looking to learn wherever I can.…
- MAC
- MAC
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud I am so healthy, superb physical shape, eat strict keto, OMAD. Exercise religiously. Never had any illness, or taking any meds. My biomarkers are stellar. Why would I take it?
- MAC
- MAC
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud The science is promising, but I'd like to see real longevity and all cause mortality data in HUMANS. Has anyone on this forum posted on epigenetic clock JUST on rapamycin? (vs.…
- MAC
- MAC
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: DNA methylation test @Fred Cloud yes have seriously considered it, worried about long term subtle mtor2 suppression. There are rapalogs in development that only target mtor1, but probably years away from approval.
- MAC
- MAC
- 3 yrs ago
- 1
- Assessing Biological Age
- Reported - view

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