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Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
You didn't change diet or exercise whilst ramping Rapamcyin? I was concerned too on exercise blunting, but have found no such effect at 4mg/week. Are you doing this flying solo, or doctor supervised?…
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@Brin Chikovski ok I figured. Did you start out at 10mg or work your way up? Other than the wound comment, any other side effects, positive effects actually measurable?
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@Brin Chikovski Brin, you are taking 10mg I assume 3x per day, re every meal? 30 mg per day? I just started on 4mg once per WEEK. The prevailing thinking on Rapamycin is intermittent at best not to…
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith Started my first dose 4 mg weekly Rapamycin. No obvious effects. Most importantly, my exercise regiment and recovery seem unperturbed.
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Staffan Olsson I added Spermidine to my stack about a year ago. https://lzrlabs.net/order-37061865 My hair is far less grey than my peer male friends my age,…
- MAC
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Peter H. Howe apoe3/3 well that’s a better starting point, but still 60% of AD is 3/3. But apoe is NOT singularly causative, it’s a complex polygenic risk disease.…
- MAC
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Peter H. Howe Healthy 80 yr old..you are way ahead of the game Peter! Less than 1% chance...depends, are you APOE 2/3, they are highly enriched for longevity vs. say APOE 4/4.…
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith The after lipids is with berberine and metformin correct, which would help blunt glucose and possibly lipids? Do you have results before/after with just Rapamycin?…
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith Thanks for sharing. I'm on strict keto, one meal day diet, and haven't had any issues, although to be honest, don't recall my doc asking for urine PH to be tested.…
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith The fact that Rapamcyin, being a macrolide, is not specifically mentioned in the article hardly gives me scientific comfort. Surely they would not have listed every macrolide in existence,…
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Peter H. Howe This is a really interesting debate. As it relates to aging and sarcopenia, it's now contested that it's actually OVER-ACTIVE mTOR which contributes to sarcopenia,…
- MAC
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith Just doing a bit of a deep dive on berberine. You say you take 500mg berberine with Rapamycin? I've read some papers and references that berberine and macrolides (of which Rapamycin is…
- MAC
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@David H Not swayed. I am 55 yo, very lean and fit, following a strict ketogenic diet, OMAD (one meal a day) time restricted feeding. Glucose and insulin signalling are not any metabolic concerns;…
- MAC
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Stevan Lieberman Thanks so much for the n=1 post on Rapamycin and resistance exercise! I've been hesitant to add Rapamycin to my longevity intervention stack,…
- MAC
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Is IRON the next anti aging target?
My ferritin bounces around from between 15-35 depending on what I’ve eaten in the interim. Ferritin is also not that accurate the cellular iron stores;…
- MAC
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Is IRON the next anti aging target?
I donate about 500mL every 8 weeks (Canada). My Ferritin last labs was 15, saturation 20%. Iron dumping is just one of the my longevity hacks, for many of the reasons already posted above.…
- MAC
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments.
If anyone is interested in epigenetic aging measurement, Rhonda Patrick has an interview with Horvath himself, full of amazing biological/aging insights. https://www.youtube.com/watch?v=A_aaBKubJnA
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Peter H. Howe I see, you completely misunderstood my post, my bad. Did not imply that in the slightest. I was only discussing completely separate topic of donating blood to dump iron and for…
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Peter H. Howe I was referenced in your post about "not agreeing with MAC"? What exactly do you disagree with? Was it with regard to iron levels? I think you referenced hormones,…
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@roger larre Sorry to hear about your grandmother and father. Recent review article on the issue: The Impact of Low Hemoglobin Levels on Cognitive Brain Functions https://www.ncbi.nlm.nih.…
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Mark Thimineur Mark, on longevity and APOE: APOE2 is associated with longevity independent of Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588231/pdf/elife-62199.…
- MAC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Mark Thimineur 6/15 over 100! Looks like you won the genetic lottery, and thus your epigenetic data is not surprising. And it doesn’t seem at all you are waiting for anything...…
- MAC
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Mark Thimineur So your lower epigenetic age is most all "genetics" your surmise? You already measured 9 years younger prior to interventions. "Tremendous longevity" is quite a strong familial…
- MAC
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Steve Roedde Absolutely. Like I said, all I care about is positive trending for biologically "positive" markers that I can/choose to measure, and net outcome.…
- MAC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
We may NEVER know what is singularly or in combination causal. But one can either be purist process or transactionally end result driven. On the latter,…
- MAC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view

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