Details of dasatinib + quercetin study

What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?

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  • Hi Ozone, thanks for the question. 

    The researcher conducting that study intends to publish the full details in a peer-reviewed journal once the study is completed. 

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    • Maximus may we presume the triggering of autophagy by fasting does not mimic chemical intervention?

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    • Joseph bailry III Hi Joseph. 

      From my understanding, that is not a simple question to address, though I recently came across a recent research report that suggests that fasting does not have the same effects as chemical intervention like rapamycin. 

      Basically, fasting reduces mTOR, but senescent cells seem to keep mTOR elevated all the time, even under fasting-like conditions. Chemicals like rapamycin seem to "force" mTOR to turn down, even in senescent cells that usually have it elevated all the time. 

      Turning mTOR down generally enhances autophagy. 

      Thus, compounds like rapamycin could be expected to have effects that fasting will not. 

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  • Does anyone know what Compounding Pharmacy carrries Dasatinib?

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      • Kerry
      • Kerry
      • 1 mth ago
      • Reported - view

      Brennan I continue to inquire but so far only sources from India and China. I am frozen in action. How about you.?

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      • Brenda Van Dyke
      • BrendaV in Calif
      • BrendaFromSoCal
      • 1 mth ago
      • Reported - view

      Kerry Do these sources require a prescription? If not will you post the links?

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  • Attached is a chart showing the dosages that were used.

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  • In process of a trial of Dasatinib and Quercertin.  Begin yesterday morning, at 9:30am  I calculated the dosage at 200mg Dasatinib and 2000mg Quercertin.   I was able to obtain 20 mg tabs of Dasatinib, so I took 10 tabs.  I obtained 500mg tabs of Quercertin, I took four of these.  I noticed at approximately 3-4 hours very mild nausea, but no vomiting.  I took the trial on an empty stomach and at 4 hours had a cup of soup, no problem and it resolved the nausea.  All was well all day until around 8pm when I ran a mile fever of 99-100 degrees.  Took a 500mg Asprin and I went to bed at 9:30 with chills , low grade headache and general malaise.  I had chills for several hours, and slept on and off over the course of the evening.  Woke up at 8am today, no fever or chills, just a little tired.  All of this seems to be inline with reported symptoms by other experimenters.  Will advise if any physiological change.

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 mth ago
      • Reported - view

      David Michel Just an update at 5 days post ingestion of D+Q.   The aftermath is that I have been tired, and a little brain fog.  This hit me harder that I though it would, but as I am 76 years old I suppose I have more Senescence cells than a younger person and correspondingly more die off. I am still going to do the second dose this Monday, but not looking forward to it.  I will advise of the outcome.

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 mth ago
      • Reported - view

      David Michel Begin my second round of D+Q this morning, one hour ago.  Took on an empty stomach so the dosage does not compete with other nutrients or drugs.

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 mth ago
      • 1
      • Reported - view

      David Michel Day two of the second round of D+Q.  The second round has been much easier than the first round.  I had no symptoms other that a mild headache which resolved with a 500mg aspirin.  I had to chills or fever. Second day feeling normal.  I think the first round must have removed a number of Senescence cells that were sensitive to D+Q so by the second round there probably were not a lot to remove.  This makes me think if studies say the D+Q combination only remove 1/3 of Senescence cells the remaining cells must require another protocol. 

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 mth ago
      • Reported - view

      David Michel I had no fever or chills.

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    • David, at 76 do you  have now or in the past had any joints with arthritis?  You are one of the best self testers on this site. I am 70 and use metformin, fisetin, aspirin, quercetin, coq10, and a few other hard to remember named supliments. I am considering rapamycin and dasatinib when I can get script.

      Second question, have you heard of any rapamycin users who have reported cataracts, or testecular atrophy from intermitant  rapamycin use? 

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      • djmichel
      • CDR Phx
      • djmichel
      • 2 wk ago
      • Reported - view

      are we there yet  If I have any arthritis it is very slight, occasionally I seem to have positional postural stiffness, and have had some idiopathic peripheral neuropathy  which seems to have not been hurt or helped by my testing. 

      You don't need script to order out of the country.  

      As to  any side effects of Rapamycin, I am taking Sirolimus which is another name for Rapamycin.  I have been taking it for two years.  I have made the following observations:  About 6 months into taking 6mg weekly, I developed idiopathic nausea and vomiting.  Doc's could find no reason for this, however I stopped taking rapamycin for 3 months and resumed at 5mg  every two weeks ,as I take a lot of things that reduce MTOTC1. There have been some report of stomach problems associated with Rapamycin thinning  mucous membrane and this may have been the cause of my nausea and vomiting, but who knows.  It has not returned.

      It is frustrating to me that I cannot find a local doc who will monitor for me, however to stop, in my opinion, is like being in an airplane headed straight toward the ground with no pilot and failing to try to fly the airplane.  Time waits for no man and at my age I do not intend to sit idly by and pontificate on why I should not experiment.  I wish that I had unlimited funds to test my results but I will not let that stop me from searching for a solution to slowing aging.   

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    • David  Thank you. I found a local Dr. in Houston that will likely give script for sirolimus next monday. She was very intrigued by dr.Alan Greens website but wanted to read more before writing script.  So I will likely add Rapamycin to my experimentation. First I want to do a new full lab panel and aecho cardio  for cardiac ejection fraction for a baseline for later reference.

      I am 70 and agree with you David, that at our age , wise experimentation is better than waiting for finished studies.

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  • David, How did you find a physician in your area who would prescribe dasatinib?

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  • I didn't, my physician just put his head in the sand.  I found a source in India who does not require script.   This is one of my largest concerns, trying to find a Doctor who is leading edge and not afraid to prescribe off label.

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      • Brenda Van Dyke
      • BrendaV in Calif
      • BrendaFromSoCal
      • 1 mth ago
      • Reported - view

      David Michel 

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  • If you read the section on Rapamycin you will see where I listed a company in Indian through which I obtain Rapamycin, this is the same company I purchase Dasatinib from.....

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  • Thank you David, I will look for the section on Rapamycin, I get mine from IAS. You are right about the doctors, they are all afraid of the tyranical FDA, the enforcement arm of Big Pharma.

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