SGLT2

Looking for a source for SGLT2 (Jardiance, Forxiga, etc.); if you're not familiar, review Bill Faloon's latest 20 minute discussion of same on this site; will probably need to be an overseas pharmacy; any suggestions appreciated

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  • I just ordered some for the first time from “alldaychemist”. Will see how long it takes to get here.

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      • Jerry
      • Steady_Rider
      • 12 days ago
      • Reported - view

      Karl  

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  • I just ordered from Oddway International

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    • Paul Beauchemin Thank you.

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      • Jack Black
      • Jack_Black
      • 18 hrs ago
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      Paul Beauchemin FYI my antivirus goes crazy on that URL.

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    • Jack Black well, yea, they are trying to censor you. Why I use duckduckgogo

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  • Canadian mail order pharmacies are greatly cheaper. Be aware jarvidance may raise your cholesterol LDL, otherwise appears safe. I wish I could dose at 5 mg pills but 10mg is their lowest and they are timed released.

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      • Karl
      • Karl.1
      • 10 days ago
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      are we there yet what is website for Canadian pharmacy?

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  • So is SGLT2 the latest thing to replace metformin? Paul Beauchemin

     

    Thank you

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    • Michael Something Bill Faloon is advocating. Can take both

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      • Michael
      • Michael.1
      • 10 days ago
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      Paul Beauchemin 

      Thank you

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      • Karl
      • Karl.1
      • 10 days ago
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      Michael although both are meds for diabetes, I would not say it’s a replacement.

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  • Please post the link to the Bill Faloon, I dont see it.

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  • Fred, go to bottom of the page and punch the see video icon . It comes up when I hit the keyboard  The video that comes up on my computer is mostly through the presentation. You need to take the time bar at bottom of the video back to beginning. 

    Good luck. 

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      • Fred Cloud
      • Fred_Cloud
      • 10 days ago
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      Peter H. Howe I dont see any link to any video on this page. Please post link.

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    • Fred Cloud Peter H. Howe is this it? https://youtu.be/VHs_2Dv8MkU

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    • chuck stanley Yes, make sure you take time line back to the beginning. If ad comes up skip ad. 

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    • Fred Cloud Attached actual video

       

      https://www.youtube.com/watch?v=Xgg6rNjSeo8

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      • Fred Cloud
      • Fred_Cloud
      • 10 days ago
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      Peter H. Howe Thank you !

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  • Those who want to go the herbal route, see below:

    https://www.sciencedirect.com/science/article/pii/S2667031322000112

    •  Another study showed that methanol extract of root of Sophora flavescens Aiton and its active flavonoid antioxidants like Kuwarinone, Sophorafalvanone G, Kushenol K, and Kushenol N, inhibited SGLT2 by 99.7% in hSGLT2- COS1 cells (Sato et al., 2007)
    • Furthermore, Qu and his groups demonstrated that 1 mg/ml concentration of ethanolic extract of Schisandra chinensis (Turcz) Baill. resulted in 89% of SGLT1 and 73% of SGLT2 inhibition in hSGLT1/2-COS-7 cells (Qu et al., 2015).
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      • Karl
      • Karl.1
      • 9 days ago
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      Juan Daw great information.  Thanks. Are you taking any of these?

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      • Rod C
      • Rod_C
      • 9 days ago
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      Juan Daw Schisandra is known to be an adaptogen. I'm not aware of a glucose lowering effect in practice.  But I was testing with herbal alternatives for acarbose. White kidney bean extract and Arabinose were effective, as evident by giving myself a standard chow of granola cereal and testing my postprandial glucose level. ~37 point reduction compared to control (me eating granola with no glucose support). That was 1 hour after meal. Glucose was back to normal levels after 2 hours.

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      • Juan Daw
      • saxxnviolins
      • 8 days ago
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      Karl Waiting for my rder of schisandra.

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      • Juan Daw
      • saxxnviolins
      • 8 days ago
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      Rod C Thanks for the info on white bean extract. Motivates me to cook callos Madrileños and substitute the chick peas with  white beans.

       

      For acarbose mimetics, been on bitter melon and mulberry leaf extract for two weeks. Haven't done any tests yet.

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  • A very low cost method of suppressing sglt2 is the Chinese herb schisandra. All parts of the plant.

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  • good suggestion; I'll follow up

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  • It looks to me like these herbal supplements have only been studied in vitro. And even if they do work, how do you determine a dose?

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    • Karl bottle schisandra recommends 2 pills a day, or about one full teaspoon

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      • Karl
      • Karl.1
      • 2 days ago
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      are we there yet was hoping for something a bit more scientific.

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    • Karl 

      Karl plant sources vary with sunlight, soil, etc. but aravedic and Chinese herb medicine have always been less exact than western drug companies, but in this sglt2 case, plants are vastly cheaper than sglt2 drug prices. That is the trade off.

      However if you have a glucose test kit, you can monitor blood glucose before and after over several days, and then average to get a best dose and strength estimate

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