NAD+ Patches
I recently purchased NAD+ from the NAD treatment center in San Diego. I purchased the NAD+ patches, 6 each @ 400mg each. The patches are a electrophoresis type patch that uses a battery to drive the NAD+ into the skin. The six patches were $300.00. I spoke with Jennifer ( 944-623-7587 ext. 5) at the center who arranged telephone consultation with Dr. Milgram. The product was fulfilled by Archway Apothecary in Covington, La. I also purchased a NAD+ nasal spray which the Doc said goes directly to the brain. To date I have used three patches and continue to daily take NR. After completing the patches I will post my results/impressions.
Best,
David Michel
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Call me skeptical, but is there even a hint of data in published literature that NAD+ gets across skin in quantities large enough to affect physiology, iontoporesis or not? I can find none on MEDLINE.
Just because somebody sells something, doesn't mean it works. You can (for example) buy B12 skin patches. They are garbage. You can buy B12 nasal gel, and sublingual B12, but there is no evidence that they work better than a pill, and some evidence in the case of sublingual that they work exactly as well as the same pill dose, since you eventually swallow the B12 (but you pay a LOT more money).
Heck, you can buy magnesium ion skin creme. There is one study that claims it works, but when the Israeli army tried to replicate it, they found what you would expect: nada.
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DanMcL The "nada" is from the fact that charged ions like Mg2+ are not expected to cross skin from just application. If they did, a swim in the ocean would kill you.
This is not The Church of Bill, complete with Holy Scripture. Who knows why Bill said what he did, or who told him what? Without a study, it's hearsay. Perhaps usable if _a priori_ likely (as in Bayes' theorem), but not very useful, if _a priori_ not likely. Like my report that green chilies give me a tummy ache, vs my report that aliens landed a saucer in my back yard last night. Extraordinary claims require extraordinary evidence, and the idea that 20 mg NAD+ in a patch is the same as several hundred mg in direct IV, is counterintuitive at best, and a probable mistake or even tall tale, at worst. That pinhead worth of NAD+ could be anywhere, and the liquid that holds it still in your stratum corneum-- a really expensive moisturizer.
We do science as we do it because that's how we avoid mistakes. A simple study of blood levels of some vitamin or coenzyme in humans, is NOT that expensive. I've done half a dozen of them with CoQ10.
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Steve Harris OK then fund your study.
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Steve Harris Hi Steve.
Bill, Brian, and I are aware of one researcher who has investigated using NAD+ iontophoresis patches to successfully raise serum NAD+ levels, but the results are not yet published. So, know that this is a cutting-edge result that has been reported by a colleague and researcher we trust, but has not yet been published, nor replicated by other groups. We're also wanting to see it replicated, of course.
But we're also interested in saving people the trouble of hours and hours of IV infusions of this stuff. If you can get similar results with a transdermal patch, that's far more convenient than intravenous administration.
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Steve Harris The ocean is pretty neutral so there is on driver to push ions into you. However, if you add some voltage to salt water...
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Furthermore, for example I started testosterone therapy using a compounded gel. I haven't done my first blood test to I can verify it's working! Regardless it's got millions of men using it and FDA approval which requires clinical data so it does work.
So, you can rub a simple gel on your skin that dries in a minute and get a hormone infusion within a few minutes. So in practice skin application does work. I suspect it has to do with water solubility, carrier and molecule size. If it's water soluble you need an electric field to help it along. If the carrier is too viscous (e.g. magnesium skin cream) then it won't work. And if the molecule structures are too large (e.g. long chain polymer) that won't make it in either.
Friends: I'm on my last patch and yes there is enough left in the eye dropper for probably a couple more applications. NAD+ party anyone 😀 Just kidding, but it looks like they give you some extra.
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How do you get a prescription? I'm thinking my regular doctor is going to say "what is that?" or maybe "why do you need that"?
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DanMcL jazzman I use a testosterone cream that I rub into to my upper arm. It is compounded by a compounding pharmacy, Post Haste in Hollywood Fl. 1-800-230-5553. This pharmacy is a supplier to Life Extension Foundation. I have been using the cream for ten years, my most recent testosterone reading was 700. It is applied using click applicator. The cost is about 40 dollars a month, and I generally purchase a three month supply. I do this by mail and phone. It does require a prescription. The prescription should indicate: Apply 4 clicks (100mg) 5 days a week. The reason for only 5 days is so the body does not forget how to produce testosterone. I have had three different doc write this prescription as I have changed docs due to insurance , displeasure, retirement, etc.
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djmichel thanks for the detail, that’s a bit cheaper. Does the body really forget with constant application? I’ll talk to my eurologist about it. He’s a bit rough and tumble though, he wanted to do shots and didn’t care about monitoring DHEA and estradiol
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DanMcL I really don't know, however two docs have told me that. I guess to have a definitive answer you would need to talk to a specialist. However I have done that for ten years and my test all come back great....
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jazzman You have to find a sympathetic doc. My regular doctor is like that, I had to squeeze his arm to get a homocysteine test in addition to regular blood work. Crazy! I think the insurance company squeezes them, but in my case my insurance has a sky high deductible and we have a HSA account, so we pay for everything anyhow. Great deal for us, we're healthy so the HSA gives us a lot of flexibility, except for the doctor. So, just go to a different doctor. In town we have one who runs a anti-aging clinic. No insurance accepted, but he's quite open to alternative ideas. Took me a few months and a bunch of failed toys to find this doctor, so keep trying.
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djmichel My prescription is for 1.6% gel (it comes in 1% or 1.6% I believe), 1 pump (1gram) daily. Do you know your strength (1 or 1.6%), and does the 100mg refer to the amount of testosterone or the total amount (presumably the latter)? Mine also says 20MG/GM, which I believe indicates 20mg of testosterone per gram, or 20mg/pump (20mg/day).
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djmichel body builders like the books written by Clarance Bass are aware that constant use of testosterone shrinks tested and the ability to make your own T. Clarance cycles T on an off every other week if I remember. Last I heard he was stil in bodybuilding competition shows in his late 70’s.
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are we there yet spell check correction. ‘Testes’ not tested
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New article referencing a study performed at Harvard and MIT that concluded that NAD and it's precursor specifically nicotinamide mononucleotide reversed key symptoms of old age. The article is Here:
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djmichel I tried calling the phone number you gave for the San diego-based NAD clinic you wrote about. about. The phone call would not go through. Can you verify the correct phone number?
Thank you
PS
In the early sections of this form, the cost for the Archway aNAD+patch kits is listed as approximately 6 kits for $100. This week I purchase from archway and was charged $100 for one patch kit. Has the price for these kits gone up that much in the past few months?
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Try looking up Dr. Philip Milgram in San Diego. He is the prescriber. I think 100 for one patch must be an error. Dr. Milgram charges 200+ for a 6 patch prescription. I do think that Archway Apothecary in Covington La. is the pharmacist. Call and speak with the pharmacist, Ray Wilkes and he will probably give you the name of someone near to you. his number is: 1-844-701-0800.
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Bill M
DJ...didn’t see any positives for n the patches....I’m 67, athlete. I’m thinking the drip is better.....
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I just ordered Nuchido's "Time" (nuchido.com) based on Andre Grases recommendation after he heard the CEOs talk at RAADFest. They claim "Time" (no ingredients given yet) raises NAD+ 4x as much as NR/NMN! Haven't gone through the ref.'s yet.
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Dennis How to like "Time"? Do you have a pro/con list?
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jen Smith Sorry no list, too much new research on other stuff to evaluate well. Had ordered 3 containers of NMN so am back on it (combined w/ an NR tab) until I get more info.
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jen Smith May try the patches next.
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Had to click below the image of the product to get the ingredients for "TIME"! Claim much better NAD+ increase vs. NR/NMN!
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Qalytude just sent an email that they can now provide NAD patches. Two options for purchase:
- $160 for 6 patches (one time purchase)
- $145 for 6 patches (recurring subscription every 6 weeks)
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Thanks for that info David. Haven't heard of them before. Interesting however, as a test I clicked on Metformin Rx and PayPal payment came up. No, indication for physician contact. So, I'm uncertain about using them, although everything else seems in order. On another note, I'm somewhat disappointed to see a dearth of physicians that are on board age-reversal.net willing to engage the protocols. If anyone has a specific recommendation for one in California, please let me know.
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Dorian Gray David Hanson Thank you David and Dorian.
We have listened to the feedback and changed the flow of the website. You now can complete the medical intake which will be reviewed by the physician and then if your request is approved you will be asked to make a payment after which your order will get shipped.
I can also share the following regarding efficacy of the patches:
"James Clement at Betterhumans Inc has run a clinical trial in 2017 that shows that a 400 mg patch raises the wearer's plasma NAD+ levels by about five times, and the effects are additive if you put on multiple patches at a time (e.g. about 9-10 times with two patches and 10-15 times with three patches at once). "
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