A Spreadsheet for Calculating Your Levine Phenotypic Age
An excellent paper by M. E. Levine, et al, entitled "An epigenetic biomarker of aging for lifespan and healthspan" describes a technique for combining nine blood-work values with calendar age to calculate your Mortality Score (probability of death in the next ten years) and your Phenotypic Age, i.e., your apparent biological age as implied by your blood variables. The calculation procedure is rather arcane, involving non-obvious unit conversions, exponentials, and logarithms, so I have produced an Excel spreadsheet (LINK) for performing these calculations.
Levine, et al., also used an elaborate DNA analysis of many blood samples to find what they call the DNAm PhenoAge, a measure of the degree of DNA methylation present, a phenomenon associated with aging. They correlate this measure with the Phenotypic Age, showing that they track very well. My spreadsheet uses a fit to their plots to estimate your DNAm PhenoAge and the modified Mortality Score that it implies.
You may already have blood-work giving the nine blood variables needed to use this spreadsheet, but if not they can be obtained by purchasing the blood-work of LifeExtension's Chemistry Panel & Complete Blood Count (CBC) ($35) and their C-Reactive Protein (CRP), Cardiac ($42). On the spreadsheet at the upper line of blue numbers, you simply enter your values in place of the ones presently there and enter your decimal calendar age in the last column. The calculated results then appear in red on the last line.
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I have seen the exel sheet that uses Levine's paramteres & coefficents to calculate
MortScore
What confuses me is a parameter "t" in years
I donot tunderstand the meaning of it.
For example, you can put 10 years or 20 years.
Mortality Score changes. And that is expected. The longer the time frame, the higher the probability of mortality.
However, the resulting phenoage also changes. That does not make sense to me.
Can someone please explain?
Thank You
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Hi Folks, just wanted to let you know that we put Dr.Levine spreadsheet into a free and simple to use web page (click here).
Want to make this accessible to everyone, so we have also negotiated wholesale price with Quest Labs for anyone who wants to get their bloodwork done. You would get the 9 biomarkers required for the Levine clock (plus additional 18 markers, 27 total) . This including blood-draw and doctor order for $75 (and since we just launched today - happy to give anyone on the forum $15 off - use coupon AgeReversal). You can learn more here -
Hello,
I started Hyperbaric oxygen therapy following the israeli study that it improved telomere lengths and reduced senescent cells. I am trying to get blood work done that combines blood glucose, lipid panel, RBC, WBC , testetrrone, CRP, as well as telomere and senescent cell level testing - so far i have not been able to find a lab test that covers all these. As I already started with HBOT session, i am in a rush to find an option that one stop shop that tests for all the above biomarkers to baseline at the beginning of HBOT and then again at end of 60 sessions of HBOT...if any one has a recommendation, kindly share.
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Very informative interview by Rhonda Patrick to Steve Horvath, much work the time!
https://www.foundmyfitness.com/episodes/steve-horvath?utm_campaign=steve_horvath&utm_medium=email
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New Spreadsheet Link
There have been problems accessing this spreadsheet from DropBox, and also from MS Cloud, where someone named Karen recently replaced it with a blank file! I just placed a new copy of the spreadsheet on Google Drive at this LINK. I hope we have better luck there.