Anyone notice better dental health on rapamycin?

I've been on Rapa for three years and my last dental checkup looked great. I will have to go back and get copies of my records to verify improvements.  

Taken together, our data demonstrate that a short-term treatment with rapamycin in aged mice is sufficient to target three clinically defining features of periodontal disease: periodontal bone loss, periodontal inflammation, and pathogenic changes to the oral microbiome. To the best of our knowledge, this is the first report of rejuvenation in the aged oral cavity. It will be important in future studies to determine whether these effects are mediated through local inhibition of mTORC1 in the gingiva and periodontal bone or through systemic effects on immune function or other tissues. Likewise, it will be of interest to understand whether additional features of oral health that are known to decline with age, such as salivary function, are improved by rapamycin treatment. Finally, these results suggest the intriguing likelihood that additional geroscience interventions, such clearance of senescent cells, may phenocopy the effects of rapamycin in this context. Such interventions could pave the way for the first effective treatments to reverse periodontal disease and improve oral health in the elderly.

https://www.biorxiv.org/content/10.1101/861369v1.full

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  • This is an exciting possibility of benefit. I will start self-experiment with rapamycin in a few weeks. I'm curious. Since you've used it for three years with an apparent lack of adverse effect, what is the dosage you are taking? Thanks

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      • Larry
      • Larry.1
      • 4 yrs ago
      • Reported - view

      Sanford Finley I started at 2mg a week, then 3mg a week and now do 4mg every 10 days. 59 years old. 

      Like 1
  • If you had bone loss prior to Rapamycin it would be evident on dental radiographs as well as any improvement, although three years is a short period in the progression of periodontal disease.  It should be enough time to show  bone growth.  Compare your xrays from 5-10 years ago to now.  If you have higher bone levels than previously,  likely it is from Rapamycin because there are no other known bone regeneration methods in perio treatment. 

    Like 1
      • Larry
      • Larry.1
      • 4 yrs ago
      • Reported - view

      Dorian Gray Difficult to see bone growth on a dental x-ray. There must be some program that can see a difference but I don't have access to that technology. 

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    • Larry It's a comparative thing.  As you can see bone loss from the level of bone up to the cementoenamel junction, you would see a decrease in that  distance if there was bone regeneration.  Changes in pocket depth could be due to a reduction of inflammation of the periodontal soft tissue.  To have bone regenerate and crawl back up the root would garner the first person to describe it a Nobel prize quite likely.  It would be one of the Holy Grails of dentistry. 

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      • Juan Daw
      • saxxnviolins
      • 2 yrs ago
      • Reported - view

      Dorian Gray Below are three studies of the use of azithromycin to regenerate alveolar bone, complete with x-rays of the patients. The Australian (Hirsch) and the Japanese (Fujise) had only three patients each. The American had 227, collected over the years. The Australian and Japanese only used one course (500 mg) for three days. The American used 500 mg for three days, for three weeks. 

      https://onlinelibrary.wiley.com/doi/full/10.1111/adj.12177

      https://onlinelibrary.wiley.com/doi/full/10.1111/j.1834-7819.2010.01227.x

      https://www.researchgate.net/publication/51629350_Benefits_of_additional_courses_of_systemic_azithromycin_in_periodontal_therapy

      Like 1
    • Larry
    • Larry.1
    • 4 yrs ago
    • Reported - view

    I've been on intermittent rapamycin for almost three years. I looked at my pre-dosing dental pocket measurements and compared them to post dosing (about 2.4 years later) and saw a 27% improvement on my upper teeth and a 5% improvement on my lower teeth total additive pocket depths. 

    Like 2
    • Ray Es
    • Ray_Es
    • 4 yrs ago
    • Reported - view

    The study used eRAPA, encapsulated rapamycin, by Emtora Biosciences (previously Rapamycin Holdings, Inc.).
    Emtora was seeking to gain regulatory approval using the drug to treat an oral disease in cats.
    Does anybody know if this cat dug is available yet?

    https://emtorabio.com/technology

    https://www.businesswire.com/news/home/20150716005141/en/Rapamycin-Holdings-Opens-Investigational-Animal-Drug-Application

    Like 1
  • My wife and I have both been taking Rapamycin for 12 weeks now. I take 6mg 1X per week and she takes 2mg. I have personally noted no effect as yet however my wife has periodontal disease and had her dental check-up today. The dentist commented that her pocket had shrunk from an 8 to a 7 which was, in his words, "astounding".  Since there has been no other change in her routine I would hazard to infer a plausible causal relationship with the Rapamycin.

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    • Sanford Finley The dentist was exaggerating  - a gum pocket going from 8 to 7 is "usual". Astounding would have been 8 to 3 or 4. Rapa may or may not be the reason for the slight improvement.

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    • Sanford Finley "Rapamycin rejuvenates oral health in aging mice"10.7554/eLife.54318

      This benefit has been quite obvious to me!!

      Like 1
    • Mark Thimineur Thanks for the interesting link, Mark! One curious question, what dose regime of rapamycin do you take?

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    • Michael
    • Michael.1
    • 2 yrs ago
    • Reported - view

    Bumping this question

     

    Pretending Rapa CAN have a positive periodontal impact, how about administering it not systemically but locally via swishing it around for X # of minutes X times a week at X concentration? Anyone know what that might look like?

     

    Thank you!

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    • Michael I think any positive benefit would be at the cellular level of the gingiva.  But swishing it around would not allow much penetration of the intrasulcular tissue and dilution with saliva would probably a negative also.  To truly know if it might have a localized effect it would have to be encapsulated in some type of time release vehicle and placed around the tooth.  Arestin is that type of product but an antibiotic.  Then getting to the underlying bone to effect any type of regeneration is even more problematic for a surface treatment.  Dentition is a complex biology.   

      Like 1
      • Walt Fair
      • Walt_Fair
      • 2 yrs ago
      • Reported - view

      Dorian Gray 

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      • Walt Fair
      • Walt_Fair
      • 2 yrs ago
      • Reported - view

      Walt Fair 

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      • Walt Fair
      • Walt_Fair
      • 2 yrs ago
      • Reported - view

      One of the most apparent changes physically since I started taking rapa in August 2021 is that my gums no longer bleed. My skin tone has improved dramatically as well. It is especially apparent on the backs of my hands. Veins no longer protrude and I no longer have to use lotion to combat dry and cracking skin. 

      Like 3
      • Michael
      • Michael.1
      • 2 yrs ago
      • Reported - view

      Walt Fair How much are you taking?

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      • Walt Fair
      • Walt_Fair
      • 2 yrs ago
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      Michael 6 mg a day since last August but last week I went up to seven and I am increasing it 1 mg per week until I am taking 10 mg per week.

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      • Michael
      • Michael.1
      • 2 yrs ago
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      Walt Fair 

      I'm sorry

      6 a day is already 42 a week. 

      Have you been taking 42mg a week or 6 mg a week?

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      • Walt Fair
      • Walt_Fair
      • 2 yrs ago
      • Reported - view

      Michael Per week. If I could handle that per day I would probably live forever.

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  • The dental hygienist I saw for my last cleaning said my teeth were in great shape (I don't remember the exact words).   That's the first time anyone has said that.  The only difference was that I had started rapamycin.

    Like 1
  • https://youtu.be/gkFxsyhf7pM
    I came across this video, now I’m leery of taking Rapamycin. I’m thinking of making a skin cream with my pills I have left. Hopefully it wouldn’t possibly cause the same problem as when taken orally. I took Fosamax years ago and have always been petrified of the possibility of Osteonecrosis of the jaw and now I see this video.

    Like 1
  • My doctor warned me that rapamycin can increase my risk of developing diabetes, and I have a predisposition to it, so I'm not taking it for now. Also, it's an antibiotic, and I don't want to take it often without a good reason. I got periodontitis when I was visiting my sister in Australia, the dentist prices there are very high, but I still had to go to a local clinic https://crowndentalgroup.com.au/treatments/cosmetic-dentistry/. In my city, I`m being treated at United Dental Specialists of Florida, and so far I`ve had a cleaning. My disease is at early stage, so my doc advised me to hold off on any antibiotics for now.

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