BobM  I am starting with Metformin with a doctors prescription. I'm using the LE recommendations to mitigate any tolerance issues, start with 250mg/day, then 500mg/day, then 1000mg/day (two meals), then 1500mg/day. Bill suggests going to 850mg eventually, before each meal which is the maximum dosage. Standard dosage is 500mg before each meal. My doctor tried it but didn't continue because he felt horrible on it and wasn't willing to build tolerance. 

Bill suggests it for anybody with fasting glucose above 85. I've got three genetics defects from my Veritas report (@BrianMDelaney) which correlate with higher fasting glucose (apparently not glucose intolerance but lower production), and despite my lifelong lifestyle work my numbers are in the 90's at best, so the Metformin is a good idea anyhow. 

BobM Also worth mentioning, Metformin can drive your testosterone lower, but if you follow LE and are older than 40 probably are doing replacement therapy anyhow. If not check LE for many articles on the subject and how to proceed (compounded pharmacy cream with blood monitoring to keep levels in range. 

Dennis Fink Thanks, good to know. I watch every video of Ray's I find but missed that. 3g/day is a lot and according to Bill is above the maximum dosage (I believe this is the medical standard maximum) of 850mg x3 or 2550 (approx 2.5g), I wouldn't tell you what to do but since you were only pre-diabetic I wonder if that is warranted. There's a pattern I keep seeing with our biology is that ranging is important - we want things (e.g. exercise, macro/micro nutrients, supplements) in a range - not too much or too little. That is "more isn't usually better, and neither is little". Just a note this is not saying "everything in moderation". For example, with exercise the benefits come with moderate degree of exercise. Some people take this as "more is better" and become amateur athletes which opens you up to all sorts of issues. I work with lots of colleagues like this, people who have wrecked their bodies by over exercise (exercise induced asthma, hypertension induced from muscle work (heart has to work hard to pump through all those muscles), on and on). 

Anyhow, something to think about. 

Dennis Fink Good for you, I think that is wise. I also take a lot of supplements, approximately what Ray takes as it turns out as he details here. Question for you - do you also take Phosphatidylcholine (PC), and if so how much? This one puzzles me, Ray is a huge proponent but none of the 'lifers' such as Bill are as far as I know (though LE recently posted a research note about a study on exploring the relationship of lipids and cellar membranes here). Bill just looks at it for a source of choline for the brain (e.g. age related cognitive decline), but then notes that fixing choline depletion as occurs with aging isn't ideally solved by just shoving more choline in your body via PC. No mention of the cell membrane lipid effect. My local drip clinic has PC drips available which is what Ray does, in some years I might start doing that too. 

On quantity of suppls, interactions and possible difficulties for your liver, Bill's opinion is that we're taking such good care of ourselves that our livers are lightly loaded anyhow, and plus there's no indication that mixing them as we do has any negatives. Sounds reasonable to me. 

BobM Great! I'm at 250 this week going to 500 next week. And happy days today, my T is coming in finally, I'm expecting good things. We must sound like a bunch of freaks here getting excited about this stuff, but boy am I looking forward to restoring my hormones (free T is low even accounting for age!).  Should have done it a long time ago, but I only discovered LE recently with all of their insight on the subject. They need to work on their marketing to be more West Coast friendly if that makes sense. 

Dennis Fink Good to know, I was beginning to think I am the only one taking PC! 

Have you considered PC IV's like Ray does? It's also a therapy in Germany apparently.