Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.)
Dr. Green, a very impressive individual, gave me my personal prescription for sirolimus. I have a very good PPO (Blue Cross/Blue Shield). I took it to CVS, the affiliated pharmacy, and got a great price of about $2.90/mg. (Remember, you are only going to take about 3-6 mg/week.) With a PPO you can probably do this also. CVS wants to meter it to you with a month's worth of doses at a time, but that's just how they do things. You still have access to the full quantity prescribed.
With the prescription from my vet for my dogs, I was forced to take to the open sea. Armed with only a prescription and no insurance, the picture is quite different, but you can still get a good price. Cutting to the chase, I ended up at Walmart. The prescription was for 90 mg - price $1440. But wait! after presenting a coupon downloaded from GoodRX (that's right, just anonymously downloaded and printed) - price $396!!!! As my vet remarked, that's a hell of a charge for not looking around first! ($4.40/mg is better than taking a risk buying online, in my opinion.) Costco is pretty close to that price. At CVS/RiteAid, etc., you will pay vastly more.
You can't touch the original drug rapamune (Pfizer) unless you are wealthy or go to Canada. The problem with the online pharmacies is that a lot of them are scams. Just because they have a website doesn't mean anything. At least check to see if they have a brick and mortar location. Example: At one point I was excited by the online infomercials and wanted to take NMN instead of NR; however, when I looked up the reputations of the suppliers only one was unsullied, and on further investigation their brick and mortar location turned out to be a residential dwelling!
FYI, more than one company makes sirolimus. From CVS the sirolimus was made by Greenstone, LLC, apparently a wholly owned subsidiary of Pfizer.
Hope that helps some people who are considering rapamycin but think it might be out of their reach. If you know a doctor, great, but if you don't a visit to Dr. Green is worth the trip, and I live in CA! (round trip less than $300) Do your homework first and you will learn a great deal.
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Hello,
I just received my Rapamycin, made by Profound Products, called RapaPro. The bottle has 12 scored tablets in it with directions to take one quarter, one half , or one tablet per week(1.25 mg to 5 mg) as directed by your physician . Trying just trying to figure out now which dose to start with , for both myself and my pup! No Rx required for this product .
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Paul Beauchemin I currently take cjc-1295/Ipa combo but had better results with real hgh so I was going to try it again.
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Ellis Toussier by the way, what are your igf-1 levels when using 2 iu's a day?
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Fred Cloud Since HGH has been considered to be a TOR, will you be alternating periods of HGH with periods of rapamycin. And if I may ask, based on your previous experience, what benefits are you expecting?
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Fred Cloud $1 to $2 per iu ??? I would not trust that it is authentic.
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Fred Cloud about 350 to 550. the IGF-1 test is not very reliable, you get different results from different labs, even from the same blood sample.. but... more or less... it tells you if the HGH you are taking is authentic or fake...
See Dr. Cranton's discussion about IGF-1 tests, on my page:
http://www.rajeun.net/cranton.html
See my page:
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Ellis Toussier Fred Cloud Here's a video I thought you would both enjoy :) https://www.youtube.com/watch?v=Ap6TtBNO0uA
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Michael Ellis Toussier Fred Cloud
https://www.youtube.com/watch?v=e1BGjcpBq6w&ab_channel=RedefiningMedicine This guy is great
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Ellis Toussier Well, after one year on rapamycin my hematocrit and hemoglobin are highest levels ever, so there goes your theory (56.3 and 18.5)
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Paul Beauchemin
That's great to see that Rapa does not cause problems. I am unsure about the theory, I think it was that as we age we get worse, not that Rapa could cause this? I have looked at Ellis's site, there are some good things there. I took the blood sugar testing found out I am good, levels mid 80's, after orange juice, got around 110, and went back under 90 in an hour or so. best I could hope for. Could it have been improved by 2 years with Resveratrol, and other supplements....probably. but I had not been monitoring it so at least now I am actively looking. I don't want to take metformin as it makes fasting near impossible, I would rather fast a few times annually as I feel it is better for overall health. I believe that the body has perfect self regulating systems that we should not be manipulating with statins or metformin. Ageing is different, more like fasting. (Am I wrong?)
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Paul Beauchemin Paul, any hair loss you can detect from Rapa? Thank you
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Paul Beauchemin That is great results. I would love to get my hematocrit to even close to 50. What is the Rapa regimen you've been following? I had no side effects with 8mg per week for 2 weeks, then 1 week off, but I stopped after several months for other reasons.
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Michael already bald 30 years ago
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chuck stanley 10 mg every 8 days
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Paul Beauchemin Do you happen to know your hematocrit before the rapamycin regimen? I believe Dr. Green reported no improvement in hematocrit over 14 months of 6mg per week. In your opinion, would you think your greater benefits are explained by the higher dosage? Or are age, exercise, and too many other factors confounding the comparison?
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chuck stanley 48 and 16
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Van Dr Green is taking 12 mg once every two weeks. He does his senolytic therapy on the off week.
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Mark Thimineur Do you have any thoughts on how an average guy can find a doctor who will provide a prescription for weekly rapamycin therapy? Yes, there is you and there is Dr. Green. Searching for "rapamycin therapy" also brings up a few other doctors nationwide, but that is the problem: Nationwide is too broad. Local or regional is more possible for most of us. Unfortunately, searching through IndiaMart (so far) is like walking through a minefield. Otherwise, I would have gone that route.
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Jay Orman There is a list here:
https://www.rapamycin.news/t/doctors-that-prescribe-rapamycin-part-2/69
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Brin Chikovski Perhaps also of interest:
https://www.rapamycin.news/t/rapamycin-frequently-asked-questions-faq/59
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Brin Chikovski Thanks for the information. I've also heard of a website called PushHealth I may investigate.
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1 of 2 – reply to Jay’s question
Jay Orman asked Mark Thimineur : Do you have any thoughts on how an average guy can find a doctor who will provide a prescription for weekly rapamycin therapy? (continues . . .)
First some background, and some of my own experience which I hope you will find useful. I take rapamycin (Sirolimus from Walgreens Pharmacy), and have been evaluating different personalized doses and timing.
Rapamycin and other age management therapies (particularly off-label prescription drugs) can have serious negative side effects. They should be used carefully, and only with an emphasis on safety, and under the supervision of a qualified age management physician.
With rapamycin in particular, I have observed great differences in its effects among different people.
I have personally had some negative experiences – specifically a feeling of weakness, particularly in the arms and legs. This occurred when taking too much for my particular system. Also the problem occurred badly for most of the day when I took it following several days of caloric reduction and exercise, then taking it on the same day with fasting, senolytics (dasatinib and fisitin), and beta-hydroxybuterate.
An associate, also a physician, developed what could best be described as nasty skin sores or lesions. Another developed a rash on his face. But another associate takes 7 mg per week with no problem, along with many others. So there’s a lot of variability.
The good news is that I continue to take rap, and have arrived at what I believe is the best dose and schedule for me based upon the experience. It’s just 1 mg per week. A couple weeks ago I tried 1.5 mg, and became kind of weak shortly after. This lasted a few hours. I’ll carefully try bumping it up again sometime in the future.
I have been advised by an associate skilled in studying rap and other therapies that the body goes through "building" and "repair" cycles. Rapamycin also facilitates repair so he advised don't exercise for a couple days after taking it. I take it Sunday morning after "laughter yoga" class, and don't exercise much more than a walk in the woods that day - but clip that 2 days short and lift weights on Monday at about 6:30 PM. It’s a compromise, but surely many of you who are passionate about your own age management programs face the same kinds of decisions.
Now on to actually answering Jay’s question.
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Awesome to hear, Rob!
Do you think you feel better with the Rapa?
This that I have is manufactured by Profound Products , and the box says its made in the EU. I use Profound's Metformin, and also their low dose naltrexone, and have always found these products to be high quality, so hopefully the Rapa is just as good. I think I'll start with 1/4 tab , as I weigh 108 lbs, and maybe 1/8 tab for my 50 lb dog. My ultimate goal is to give some to my mom, but feel like I have to try it myself first haha.
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angie4life Not sure if I feel better. Under a ton of stress trying to help one of my dogs keep the use of her rear legs (disc problems), and maybe starting to deal with it better. She was getting shaky and panting a lot - she has mild valve disease but not in CHF. It seemed harmless, so I had the doggie physical therapists we are seeing try an ozone therapy treatment. I am cautiously thrilled. The panting is way down and she is much more stable on her legs, plus more energy. Basically they shoot O3 up her rear. The Os break off and oxygenate her system. Would like to try it myself. How is LDN working for you? I have it for my pups only, but one of them seemed to get a lift from it.
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Profound Products doesn't sell directly to consumers. I tried several companies they list but so far haven't found one that carries Rapa-Pro. I don't have a prescription. Angie4life, whom did you get yours from and did they require a prescription?
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Don
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