Intro to rapamycin

Paul Platt Everolimus just went generic in 2019 so its been expensive - I see the brand name product was $16K/month. Now you can buy it on Indiamart.com for $8.50 for 5mg tablets, and $10 for 10mg tablets - which works out to about $200 to $800/month depending on the dose and tablets you take. Most people go for the cheaper sirolimus which sells for $1 to $2/mg, so if you're taking 10mg in one dose per week (as I am right now) it works out to about $10/week or $40 a month - which is fine.

Brin Chikovski Everolimus is much weaker Tor inhibitor than Rapamycin taken at the same dose.  1/2 life is appx. 1/2 Rapa. (30 hrs)  You will have to take more to get the same Tor inhibition.  No benefit that I can see taking this regardless of cost.  Most trials were used using Everolimus because it was an prescription Rapamycin and the drug companies make more money.  See Mannick.

Van Help! I'm confused. So the 1mg Sirolimus Rapacan 1 tabs that cost roughly $1 a mg are or are not worth taking? Thank you!

Michael Rapamune is Sirolimus not Everolimus.  Everolimus works just have to take twice as much to get same effect.  Everolimus was developed for organ transplant patients taking daily doses to suppress immune system.

Van Thank you!

Koo I read in Science Daily in a publication dated July 25, 2013:
"[Rapamycin's] impact on aging itself is limited. The life-extending effect seems to be related to rapamycin's suppression of tumors, which represent the main causes of death in these mouse strains".
https://www.sciencedaily.com/releases/2013/07/130725141715.htm

I ask: How much of Rapamycin's life extension properties can really be extrapolated to humans?

Laurence R I'm a newbie to this field of research, and I'm sure there are others that could answer you better. It seems to me that there are quite a lot of papers that demonstrate  that rapamycin down-regulates mTOR in both human cell cultures and animals. The mTOR pathways are conserved across species, so it seems likely that there will be similar effects in humans, and the human cell cultures support that. However I think that human clinical trials are still underway to see how effective rapamycin is for treating ageing in people, others on this forum will know more about these.

Rapamycin is known to suppose at least one part of mTOR, TOR1, which controls the timing and rate of cell division, other aspects of cell metabolism and protein products. mTOR plays a key role in fibrosis, one of the major disease mechanisms in aging (eg heart disease, vascular disease, lung disease, kidney disease etc etc), and mTOR is also one pathway by which senescent cells resist cell death. So it seems that down-regulating it would be beneficial for the problems associated with aging. This is supported by a large body of research on fasting, which has similar beneficial effects. 

Rapamycin reduces the amount of inflammatory cytokines produced by cells. Increased levels of inflammatory cytokines are associated with ageing and are made by senescent cells. The inflammatory cytokines harm healthy cells in the body, eventually turning them senescent as well, like zombies. Rapamycin also reduces the numbers of Th17 cells in people with rheumatoid arthritis, see the abstract “RAPAMYCIN INDUCES REMISSION IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS” by Chen et . al. 2018. Th17 adds to the inflammatory feedback cascade of ageing and disease. But at the end of the day we are all experimenting here, and some of us may respond better than others.

Laurence R recommend you start on a lower dose maybe 1 or 2 mg along with metformin from my experience.

Laurence R I believe this is exactly what's happening to me. Either that or I finally have lung cancer.

Aaron Lahm It is unlikely that you will find, unless you specifically search for, a doctor that is up to speed on anti-aging therapy, and Rapamycin use.  There is even less of a chance that a doctor will prescribe a potentially dangerous drug for a non indicated condition.  Your best bet is to use referral list on this website.

Aaron Lahm I found my doctor through the age-reversal.net directory https://age-reversal.net/physician-directory/ . I called, doctor's assistant told me to just walk in on any Monday, waited 10 minutes in the waiting room while filling the paper work... 20 minutes later, I had my prescription for metformin and Rapamycin plus some very valuable advice. I feel lucky that he holds office only 7 miles down the road in Oldsmar (Tampa Bay area). Before that, given the potency of Rapamycin and its heavy side effects, I could not resolve myself to obtain it from a shady online pharmacy with no guidance and no assurance for quality.

Laurence R If possible, would you tell me what he charged you?  I live about 30 miles from Oldsmar.

David Hanson Howard Chipman, $150. Very good contact. General exam + interview.

The expensive part is the Sirolimus (Rapamycin). But a Good RX coupon slashed the price in half to a little under $500 for a 5 months supply, which will last me 6.5 months since I took on me to pass the prescribed weekly dose every 3rd week to recover from the Rapamycin nasty side effects.

Laurence R What was the Drs name that prescribed the meds and what was his fee?  I imagine that the RXs were costly to fill in the US.

Paul Beauchemin 

Paul congratulations, I have also seen positive results with my kidney function.  If you have ever been to a kidney dialysis center, you will be very motivated to take care of your renal health.