AWaller Yes thanks, typo. 

I believe it was a recent update at the COPL channel. Worth going through the videos there, IIRC a recent talk by Bill is where he mentioned that they're finding that folks in these studies who already practice healthy lifestyles and are taking metformin that the Rapa step can be skipped. Pretty sure I've heard him say this on a few occasions, I'll dig around and see if I can find references but worth joining COPL if you haven't It's wacky, but my kind of wacky. 

AWaller OK Bill and team just sent out a email update where he says

"Rapamycin update

A drug called rapamycin has been shown to markedly increase lifespan in every animal model tested.

Initial reports from a pioneering doctor indicated substantive regenerative benefits in response to 5 mg a week of rapamycin taken along with daily metformin and other AMPK-activating compounds.

Interim results from a clinical study, and feedback from our supporters, indicate that this dose of rapamycin (5 mg/week) may be too low.

A clinical study on higher-dose weekly rapamycin is being planned.

Until we verify safety/efficacy of this higher rapamycin dose, please consider lowering mTOR by using AMPK-activating interventions such as:

• Metformin and/or
• Restricted eating (including various forms of intermittent fasting) and/or
• Nutrients like gynostemma pentaphyllum and hesperidin.

When AMPK activity is increased in cells, mTOR is indirectly suppressed and autophagy is initiated. Autophagy is the removal of accumulated waste from inside old cells. It is an important step in restoring cellular functionality.

When excess mTOR is lowered, autophagy can help rid old cells of toxic debris.

We made a change in my video presentation to reflect our current view that the first step to age reversal is to boost AMPK activity via several validated methods."

So it looks from this that the 5mg/week dosing of Rapamycin is too low, and that it is important to activate AMPK via metformin. WIP.

I started Metformin for multiple reasons, did NAD patches, and will approach Rapamycin soon as more is known about dosing. 

Update from the linked video; hot off the press "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin

Current studies indicate a higher dose of rapamycin may be needed and a clinical trial is needed to validate safety and efficacy of the higher rapamycin dose" 

So, hold off on the Rapaymycin until higher dosage safety can be established. 

Iðunn Just relaying Bills message, and regardless he’s not saying Met replaces Rapa.