Intro to rapamycin
Hello everyone,
Rapamycin is an mTOR inhibitor. It has been used for years to prevent organ transplant rejection in humans, in part because mTOR inhibition also inhibits the immune system.
mTOR is a pro-growth factor that is involved in cellular growth and protein synthesis. Its inhibition has been associated with longer lifespans in certain organisms (not yet humans).
Rapamycin administration has been shown to extend the remaining lifespan of middle-aged mice, making it an interesting life-extension candidate for use in middle-aged humans.
Has anyone tried rapamycin? What were the results?
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I am now in Year 2 of Rapamycin @ 5mg daily. Have observed a 10 pound weight loss. No problems other that at about 10 months in I developed periodic nausea with vomiting which I contribute to thinning of the mucosal tissues. I cannot be certain that Rapamycin was the cause and my conventional doc said he though it was but didn't know anything about Rapamycin as a life-extension protocol. Of course I provided him all of the DR. Blagsklonny studies,information as well as Dr. Green's website. Bottom line I took several months off, the problem resolved and I am back on Rapamycin....BTW I am now purchasing from the new site referenced in the blog. Paid via an e check and received the product withing two weeks. Smooth transaction. I am also taking NAD+ via electrophoresis patches. I have an account under NAD+ Blog.
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David Michel Yes, a type, should be 5mg weekly
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David Michel Typo, should be 5mg weekly.
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djmichel .....Would you please spell out your pharmacy source for Rapamycin, please.
And how $ much? I'm just starting my self-trial and looking for $$$-saving source.
The suspense is terrible; hope it lasts.....nealfg
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djmichel David, do you take 5mg as one dose or several times a week?
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djmichel who are you purchasing from? What “new site”?
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Web MD has this to say in part about Rapamycin: Rapamycin can cause mouth sores, cataracts, and diabetes. It can also raise the risks of infection, bleeding, and some types of cancers, such as skin cancer. It can cause high blood pressure, fever, and anemia. How big of a concern are this potential issues? https://www.webmd.com/special-reports/anti-aging-science/20170329/anti-aging-pill
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Marc Someone who knows better should either correct me, or confirm what I write, but it was my interpretation that the WebMD article refers to side effects that may be observed in patients who have undergone organ transplant surgery, and are not only taking higher doses of Rapamycin daily, but also other powerful drugs in combination.
The article does not specify the actual dose nor the frequency of Rapamycin they are prescribed (it really should!) nor what healthy people wanting anti-aging benefits should take. So in that respect I find the WebMD article a little vague in evaluating the actual dangers, and thereby potentially misleading to the downside.
What I can gleam from reading the research on https://rapamycintherapy.com is that the longevity benefits for healthy humans relies on a strict dosage protocol of no more than 5mg per week.
Like the old adage; the poison is in the dose. Any substance can be a lethal if taken in excess; even water (hyponatremia). -
AWaller Yes. The article appears to refer to the standard usage of rapamycin, not the use of rapamycin for aging. I don't know of any research on the use of rapamycin for aging (once weekly or biweekly versus daily for immune suppression) at this time.
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Out of all the risks you list, the only one I have known is the mouth sores once in a while. Our study will wrap up very soon. I am told we will meet again as a group at the end of this. At least one of us comes from Canada. As with all things, I imagine what you experience will have to do with individual DNA and lifestyle choices.
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I just received my first delivery of Rapamycin today. Should I take it on an empty stomach or with food? Is it best in the morning or at night before retiring, or does it not matter?
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I take it after breakfast. I don't recall anyone saying anything about a best time, so I take it with the rest of my supplements.
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I take 5mg every Monday morning, I take it on an empty stomach as I do not want it competing with other supplements. That way I am assured I am getting the full dose. Does not cause any distress.
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David Michel I just spotted in another thread on this site about rapamycin in which 'BrianMDelaney' suggested taking 5 mg with a fatty meal, because of 30% better absorption than on empty stomach.
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AWaller Interesting, I'll try that.
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AWaller Some new studies show that there is a lot of inter-subject variability in the relation of food timing to rapamycin timing and resulting blood levels. So it might not matter so much when one takes the rapamycin.
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AWaller I read that eating a grapefruit before taking the Rapamycin accentuates the effect.
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I think Bill is now recommending that if you're suppressing AMPK sufficiently via lifestyle and Metformin then the Rapamycin isn't necessary.
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DanMcL correct me if I'm wrong, but shouldn't one be activating AMPK rather than suppressing it?
Typos aside, (and there seem to be a few on this thread :-)) please point me to where this particular recommendation of Bill's was voiced, as I have just started Rapamycin 5 weeks ago, and would like to know if he has made any such revision since.
I am sure you must be aware of the site pointed out to us on other places on this site, but in case not: https://rapamycintherapy.com -
AWaller Yes thanks, typo.
I believe it was a recent update at the COPL channel. Worth going through the videos there, IIRC a recent talk by Bill is where he mentioned that they're finding that folks in these studies who already practice healthy lifestyles and are taking metformin that the Rapa step can be skipped. Pretty sure I've heard him say this on a few occasions, I'll dig around and see if I can find references but worth joining COPL if you haven't It's wacky, but my kind of wacky.
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DanMcL Ok, I'll check it out. Thanks
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AWaller OK Bill and team just sent out a email update where he says
"Rapamycin update
A drug called rapamycin has been shown to markedly increase lifespan in every animal model tested.
Initial reports from a pioneering doctor indicated substantive regenerative benefits in response to 5 mg a week of rapamycin taken along with daily metformin and other AMPK-activating compounds.
Interim results from a clinical study, and feedback from our supporters, indicate that this dose of rapamycin (5 mg/week) may be too low.
A clinical study on higher-dose weekly rapamycin is being planned.
Until we verify safety/efficacy of this higher rapamycin dose, please consider lowering mTOR by using AMPK-activating interventions such as:- Metformin and/or
- Restricted eating (including various forms of intermittent fasting) and/or
- Nutrients like gynostemma pentaphyllum and hesperidin.
When AMPK activity is increased in cells, mTOR is indirectly suppressed and autophagy is initiated. Autophagy is the removal of accumulated waste from inside old cells. It is an important step in restoring cellular functionality.
When excess mTOR is lowered, autophagy can help rid old cells of toxic debris.
We made a change in my video presentation to reflect our current view that the first step to age reversal is to boost AMPK activity via several validated methods."So it looks from this that the 5mg/week dosing of Rapamycin is too low, and that it is important to activate AMPK via metformin. WIP.
I started Metformin for multiple reasons, did NAD patches, and will approach Rapamycin soon as more is known about dosing.
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Update from the linked video; hot off the press "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin
Current studies indicate a higher dose of rapamycin may be needed and a clinical trial is needed to validate safety and efficacy of the higher rapamycin dose"
So, hold off on the Rapaymycin until higher dosage safety can be established.
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DanMcL As I've posted elsewhere, it's not clear that metformin inhibits mTOR to any significant degree outside of the liver, and it clearly cannot substitute for rapamycin.
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Iðunn Just relaying Bills message, and regardless he’s not saying Met replaces Rapa.
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