Which Rapamycin brand to buy versus which to avoid?
Currently looking at buying rapamycin online, likely via India, for delivery in Europe, and I see there are a number of brands, including:
- Biocon - who sell it as "Rapacan"
- Zydus Cadila (I also see "Zydus Biogen: mentioned) - who sell it as "Siromus"
- Rocas - who just say "Sirolimus tablets" on the box
- Panacea Biotec - who sell it as "Siropan"
- Actiza - who just say "Sirolimus tablets" on the box
- Pfizer - Rapamune (unsure if genuine via India)
If anyone has experience, good or bad with these (or others), I'd appreciate it!
yes - as you may know with HPLC analysis you can identify what level of something you're looking for in a given product - in this case sirolimus by comparing it to a chemical "standard" which you know is sirolimus from companies like Sigma Aldrich - its really hard to identify other substances mixed in with a compound unless you have some idea of what you're looking for. The other compounds in the Biocon sirolimus / rapamune were completely unidentified.. they could have been just filler, or it could have been something else.
The lab I was using "Valisure.com" has stopped their services for people just looking to get their medicines tested - and have focused on their pharmacy business - so I haven't been able to find any other low cost HPLC lab testing companies for my medicines from India - which is frustrating. Valisure was priced at around $100 for quality/purity and dosing (is it actually 1mg of rapamycin) testing (Valisure also did a test on common contaminants), and they could do it all using only 3 X 1mg tablets. Now I can't find anything much less than $300 to $500 - which is more than I want to pay for purity testing, because you have to balance it with the risk of confiscation by US Customs - and the larger the order, the higher the risk. An order of about 500 tablets of sirolimus comes in a shoebox-sized package from India. When the testing is as much as the cost of the medicine I start to balk. If anyone has a good moderate cost analytical lab they'd recommend - please post here.
So while I started off this process about a year and a half ago testing all my medicines from India - now I'm not able to test any and I'm "flying blind" - which is far from an ideal scenario. In the lab tests I did on the product batches over a year ago now on sirolimus - the Zydus Sirolimus tested ok - but that was only on two batches, so with N=2 its hardly a robust sample size and there is no guarantee that other batches are as good. I'm still using up the 1000+ sirolimus tablets I ordered over a year ago - and now there are issues with the India postal service due to Covid, which is delaying orders by weeks or months.
Really we should be all testing medicines from India. I'm highly skeptical of medicines coming out of India and China (including Generics in the USA, since most of them come from India, with the API (Active Pharmaceutical Ingredients) all coming from China. I recommend everyone read the Katherine Eban book on Generic Medicines:
Just thought I'd give an update on where I got to with the purchase. I created a shortlist of sellers on IndiaMart and reached out to them regarding:
- Which brands they offer
- Prices per mg, including shipping
- Estimated delivery date
Two offered to do a video call and show the stock they had along with the expiration date, which is a nice touch.
Ended up ordering these 2 brands:
- Zydus Cadila - Siromus
- Biocon - Rapacan
I wasn't super impressed that the Biocon packaging looks different colors (its not just the lighting in the picture), like their printer was short on ink or something. Have started by using the Zydus product first, given that I can. Might be a non-issue though! Who knows.
I'm attaching images of the product in case anyone is curious.
Main concerns would be:
- Do the products actually contain any rapamycin? (am planning to do a test to check rapamycin levels at a later date, which should help clarify on that question)
- Are the doses measured correctly? (milligrams are pretty tiny). No way to be sure on this.
- Are there any contaminants (heavy metals, etc)? Currently I'm just crossing my fingers that if there are, it's a small enough amount to be a non issue. May do some testing at a later date.