Canagliflozin - A One Month Report, Its Good
I've been using Canagliflozin for the past month and really like it. It moderates blood glucose levels and makes it really easy to lose weight. I've lost about 10 lbs in 3 weeks, without really trying.
I researched it after the report form the NIA ITP study came out last year. I tried Acarbose before - but the gas it can cause was less than ideal on occasion. So I've moved over to 100mg of Canagliflozin for the first week, then phased up to 300mg in the morning. It seems to do a really good job of managing post prandial glucose levels - typically 70 to 120 during the day - see my typical daily CGM results in screen capture attached (Note that GCM measures are typically 10 to 20 points lower than I see on my finger prick blood glucose test). I eat a fairly low carb diet anyway - but this helps when I include higher glycemic index foods.
Cost was $2/per 300mg tablet from pharmacy found on Indiamart.com, so a $60/month cost, which I consider reasonable, no prescription required.
Here is the US pharmacy info if you get a prescription:
Its a good complement to Rapamycin. I think I will keep on these for the long term.
Recent Studies, Resources:
Latest Peter Attia Update on Rapamycin and other anti-aging drugs:
"There is another drug that is super exciting called canagliflozin" a more elegant version of acarbose that works in the kidney. Extends life of mice in the ITP study almost as much as rapamycin. "Discussion starts at minute 90 on this new podcast:
Canagliflozin extends life span in genetically heterogeneous male but not female mice
SGLT-2 Inhibitors as Calorie Restriction Mimetics
SGLT2 inhibitors as calorie restriction-mimetics: insights on longevity pathways and age-related diseases
Have you checked your ketone levels through biochemical measures? May I ask what your diet is like- carb intake specifically? Even though Peter Attia is taking it, we still do not have a safety and efficacy study done in healthy populations. I would be interested to see a combination of low-carb combined with sglt2 inhibitor (canagliflozin specifically) for primary endpoints on general health markers. I think canagliflozin has great efficacy for the indication of hyperinsulinemia but I'm worried of a dose-dependant effects on insulin + ketones in a healthy, large population sample.
The side effect I'd be most concerned about from combo SGLT2 inhibitor and rapamycin is bacterial infection, specifically UTI. Dr. Alan Green (rapa guru in NY) just posted an Oct 2021 update saying he has seen increased risk of bacterial infection in his 760 patients to date on weekly rapamycin. He recommends everyone taking rapa have a supply of antibiotic on hand for early treatment in case of infection. The #1 side effect of SGLT2 inhibitors is UTI because of all the glucose being excreted through the urine, and UTIs can be *nasty* (can turn into kidney-damaging pyelonephritis and deadly sepsis). So the combo of these two raises the risk of UTI and associated problems even higher. Keep in mind that Dr. Green's recommendation of keeping a Z-pack on hand, while maybe good for broad-spectrum treatment of many bacterial infections, is *not* the best choice for UTI (rather, Bactrim DS or cipro are more appropriate since UTIs are usually caused by E. coli and azithromycin doesn't work well against E. coli). Anyway, I hope the original poster sees this and strongly considers inquiring with his PCP about getting an antibiotic!
Been taking 300 mg Canaf for 3 months now. Cost 86 euros here in Spain for 30 tabs. No Rx needed. Really has dropped my HbA1c from 6 to 5. Lost 10 kg. Lower glucose levels = lower inflammation = less fat, and plaque build up in arteries. Side-effects: Noticed very high glucose excertion in urine via urinalysis. I take my B/P every morning, and my pressure was really dropping. (under 100) Have been on Linsopril for years. Stopped that and Canaf has controlled my B/P to under 110 which is where I want to be. After researching found out that SGLt2 inhibitors make you pee more thus contributing to dehydration which causes "hypotension" low blood pressure. So started drinking more fluid and seem to be very stable.
On a side note, have been taking rapa for 5 years, and no infections. Only a minor mouth sore very rarely. Currently taking 20 mg. twice a month with GFJ protocol. 75 yo male, 165 lbs. 71" Pheno Age 62 yo. As Al m said, these interventions are only for healthy people. Others should consult there physician.