Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin, my wife and I (ages 79 and 84) decided to try it. We have just completed two sets of massive Fisetin doses.
We had Life Extension blood-work done in October before the start, and we will have more again next week to observe any changes. The first set of Fisetin doses was on October 22-25 with 800 mg/day for three days followed by 600 mg on the fourth day, for a total of 4 g. I didn't notice much in the way of effects. Perhaps some reduction of small aches and pains and some increase in energy and mental acuity.
For the second set of doses done November 22-26, since we experienced no negative side effects in the first set we decided to increase the dosage a bit and to add 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids. For five days starting on Thanksgiving we took 500 mg of Fisetin and 10 mg of BioPerine twice per day, for a total of 5 g of Fisetin.
This time. I did experience one negative side effect. A few months ago, about 2 AM in the morning I awoke from a deep sleep and experienced a severe episode of vertigo. I turned over in bed, and the the whole room seemed to tilt. Suddenly, I didn't know which way was up. I staggered to the bathroom and vomited. The symptoms tapered off and disappeared in a few days, but it was a very distributing experience.
On the 2nd day of our 2nd Fisetin series, I experience a recurrence of that vertigo in the middle of the night, not as bad as my initial experience but still rather disturbing. I tolerated this mild vertigo and continued the treatment. My wife had no similar symptoms, and after my last dose I experienced no further vertigo symptoms.
On the positive side, following the second set of dosages I did feel very well, and very sharp and alert. This past weekend I ran my Shetland Sheepdog Taliesin in an AKC Canine Agility Trial in Mt. Vernon, WA, and we did very well, qualifying in 7 runs out of 15 and getting various colored placement ribbons. I was feeling quite sharp, and I even invented a new dog-handling technique that fixed an ongoing problem we were having.
Next week we will do the blood-work again, and I'll report any changes.
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David H
Dr Brad Stanfield (New Zealand) is great and I follow him as well. My comment to him was the same as on this thread. You just can't read ingredient list and believe manufacturer. The supplements in the US are unregulated; hence, no oversight and you need the third-party testing. With respect to Dr. Rhonda Patrick's second statement about efficacy, it is not her personal opinion but it is indeed fact and test based. It came from Jed Fahey at John Hopkins. Basically it seems that Dr. Patrick first sprouted her broccoli then she became too busy and started uing BroccoMax instead. At this point she may have made a few statements about it but then subsequently checked with Dr Fahey and found out what's really in the product and changed her mind on it. The moral of the story: don't put any supplement or medicine in your mouth unless manufacturing monitored by FDA / equivalent reg body in other countries or reliable lab tested.
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I need some help on this topic. My aim is to take take 1.5 g of Fisetin on 3 consecutive days.
Today was the first day. I took 15 capsules a 100 mg after a 20h water fast with 2 spoons of native olive oil, a capsule of curcumin containing perperin and an omega-3 capsule. First i wanted to dissolve Fisetin within the olive oil but seeing the small capsules i thought just to swallow it with oil, no problem. Afterwards i ate 500g of strawberries and ate as usual 1 h later.
So far i recognized some slight stomach pain. Any hints how to improve the intake besides dropping the strawberries? Should i dissolve Fisetin completely in some oil? Take everything on an empty stomach or after a meal, at the beginning of a fast or at the end, or split the intake?
Thank you in advance.
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Need I eat my fisetin on buttered toast and snack on dehydrated strawberries. I have just started.
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I'm about to try fisetin. Has anyone used that available on Amazon (Axe-NIC)? It says Pharma Grade, not for human consumption. The Philly company won't ship to Canada. Any Canadians here? The RevGenetics 500 is $99 for us on Amazon plus $10.99 shipping. I just lost my account due to the virus, so don't want to go overboard on something that's encapsulated and costs much less over the border. Thanks all.
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Antonia Gauer
Last year I ordered 100 gm of >98% pure powdered Fisetin from VitaSpace for $190 plus $6 shipping. That's $0.19 for 100 mg, still a lot better than $0.47 per 100 mg from Drs Best. Further, it's already in powder form, removing the need for breaking open capsules before dissolving in olive oil. They are located in New York, and I have no idea if delivery to Canada is a problem.
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JGC
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JGC A little lower price than ageless.one on ebay - their fisetin is $49 for 25gm plus $3 for shipping. They reduce the shipping charge for more than one item. I ordered 3 last time and they charged $4.50 for shipping.
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JGC Thank you. I will try that one.
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David H
I don't find ageless.one on ebay. Do you have a link?
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JGC Sorry! Try this: https://www.ebay.com/itm/FISETIN-98-pure-powder-extract-no-fillers-cost-effective-ANTI-AGING/293083396786?ssPageName=STRK%3AMEBIDX%3AIT&var=592361881380&_trksid=p2057872.m2749.l2649
Title of ebay listing is: "FISETIN, +98% pure powder extract, no fillers, cost-effective, ANTI-AGING"
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David H
That particular product is from CHINA. I don't know if we can fully trust what the ingredients say.
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I'm hearing that berberine and metformin up regulate autophagy where the body recycles garbage, including senescent cells.
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Also - it seems that we need to figure out how quickly you can cycle. One very 6 months would take for ever to see an effect. Why not 3 days on and one week off?
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Robert Olin you are making the assumption that more is better?
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Karl Voice of reason! I think the best approach is to mimick for now Walter's Longo's fasting protocol translating it to senolytics on how often depending on your personal physical shape. Once more studies are done, hopefully on monkeys, we will know better on how to proceed with senolytics.
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i guess I'm in a hurry. In two months I'll be 70 and my lower back is killing me. And that's after back surgery about 2 years ago. Thanks for the link to Senescent Cell Aging. Lots of information.
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Robert Olin I don’t mean to rain on your parade. I’m glad you’re here and getting involved in senolytics. There is great potential to slow or reverse aging. Unfortunately there are very few human studies available on senolytics, so it’s difficult to determine the correct dosage or frequency.
a few quotes from the recent fight aging newsletter:
“The growing numbers of senescent cells in older people (and even larger numbers in older obese people) contribute to near all conditions of aging. Removing them has proven to be very beneficial in animal studies, reversing the progression of numerous age-related diseases.
A global, always-on mechanism to remove senescent cells has been shown to improve health and longevity in mice, but is probably not a good idea for human medicine. Senescence is a harmful process only when it runs awry, when senescent cells accumulate over time. Senescent cells are constantly created in a youthful metabolism, and serve useful purposes in suppression of cancer, wound healing, and other processes. “
so, as with many things in medicine, just because a little is good does not mean more is better. And even if more is better, we don’t know how much more yet.
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Robert Olin "i guess I'm in a hurry" Best anti aging forum line ever! I am so there too.
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It would be great to share before and after blood test like JGC did. Especially so medium and long term tests to see the progress.
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This all comes from Dr. Green's site. https://senolyticstreatment.com/ at bottom of site. also, EXCLAMATIONS, and clinical trials.
12. THE NEW ANTI-AGING FORMULA
Rapamycin
Dasatinib
Fisetin
Zithromycin
Doxycycline
Vitamin C
Metformin
Dose and Interval
Rapamycin 3-6 mg; once a week
Dasatinib 50 mg capsules; 2 capsules a day for 3 days; once a month to 4 times a year.
Fisetin 100 mg capsules; 1500 mg once a day for 3 days; once a month to 4 times a year; taken with Dasatinib.
[Quercetin 1000 mg can be use in addition to Fisetin]
Zithromycin 250 mg tablets; 1 tab day for 6 days; once a month.
Doxycycline 50 mg capsules, 1-2 capsules a day.
Vitamin C capsules; 250-500 mg a day.
Metformin ER, 500 mg 1-4 tabs a day.
Other valuable drugs:
Statins
ARBs (candesartan)
Tadalafil
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Van Thanks for the list. I would be careful of the doxycycline. It has side some side effects.
From Podiatry Today:
"Researchers have now shown fluoroquinolones triple the risk of tendon rupture and the risks increase with age as well. Over the years, there have been increased reports of tendon rupture and tendinitis with other antibiotics, such as tetracyclines, doxycycline and macrolides (i.e. azithromycin)."
My dad had bad tendon issues with it. Some people will have tendons snap after taking it, though that was for antibiotic dosing. Just want people to know.
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Van
Other valuable drugs: Statins
https://www.youtube.com/watch?v=inwfSkSGvQw
Enjoy your post Van, they are always very useful. If it's not too much trouble when you get a chance take a look at this video from Dr. David Diamond PHD and post a comment if you don't mind. I'd like to hear your take..
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Gary Gilley Anyone taking or considering taking statins may want to check-out below site, with negative side effects:
One alternative is to take Red Yeast Rice (RYR) from which the Rx statin was developed.
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@Van interesting stuff. The doses by themselves seem moderate. That said together it seems a lot. I take 2mg rapamycin from Walmart once a week. Rapamycin by itself has quite an effect on me. Feel a bit like fainting sometimes, my skin itches a bit sometimes, extra thirst, shivers, brain impact during the first couple of nights after taking. Without rapa I’m in very very good physical shape. I’m concerned that without studies on monkeys first to see what this drug cocktail does just from the safety perspective put aside if it does anything for longevity, we are taking too much risk. For our safety I think we should first focus on setting up and sponsoring such studies.
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Joe smith rapa is not very toxic at all - people have tried to OD on it with 100 mg and nothing happened
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