Fisetin to Clear Senescent Cells

Thanks for the feedback, I really like the idea of trying fisetin in cream, I'll give that a try next week :-)  I might also try the coconut oil on its own at some point, to see if I react to that like you do, that's good info. I don't want to even look at it at the moment!

FWIW, I get a sore throat from plain virgin coconut oil with nothing added.

Hello everyone I wanted to give you a breakdown of my fisetin experience over the last year.

 

I went in fairly hardcore trying to emulate the experiments done with mice only in humans. And I also repeated the treatment routinely. 

 

I think the math worked out 100mg for every 15 pounds of weight. I did the math back then. Suffice to say I was around 220 lbs and I took 18 tablets (100mg each).

 

Me: 43 years old, male, 220lbs

 

The specific amounts I took were:

 

DAY 1: 18 x 100mg tablets (Swansons Brand) 

DAY 2: repeat

DAY 3: repeat

 

Initial observations where that by day 2 I was a little jittery, not a lot, but I had amazing strength in my legs and a firmness throughout all muscles. By day 3 I was feeling fantastic and this feeling became more intense for a week after and even was noticeable 3 weeks out.

 

I suspect that fisetin raises hormone levels as well. Because I felt 20 years younger and full of strength, Mentally I twice as sharp. I remember distinctly that when walking around during week one I could hear every thing brilliantly, the world was crisp and alive. So there is definitely some kind of hormonal effect or other stimulation than just senescent cell clearance. These effects were much too fast to be a result of that. 

 

I repeated the treatment at 2 weeks, then at 4 weeks, then at 6 weeks, and 8 weeks again and then gave it 5 months or so and now I am doing a repeat but at a slighty higher dosage.

 

In each iteration I noticed a powerful effect for the first week, and a great 2nd and 3rd week. And then I still maintained much of the muscle density and firmness and increased energy thereafter. I decreased the frequency I was taking fisetin due to my concerns that it was spiking testosterone somehow. After all the goal was to clear senescent cells not mess with hormones. 

 

I can say that in the year since I started, I have maintained a stronger physique, my posture is better, my abs and chest are firmer, I don't look my age, but I kinda was that way before to an extent. If I shave close people will honestly think I am in my late twenties. 

 

My view on this is the following: Any senescent cell clearance benefits will show up slowly, just like the negatives of having them in your body to begin with.  I would use hormone therapy for gender reassignment as an example. If you see how long  HRT takes to have real results its about 6 months to a year with the most dramatic results at the 2 year mark. So quickly making assessments about fisetin is likely foolish as the body needs time to regenerate lost cells, and cells which were antagonized by senescent cell signalling need time to adjust back into equilibrium.

 

Additionally fisetin is shown to be more effective in certain tissues. I think more so in muscle tissue, and some organs.

 

Overall I am seeing and experiencing good results. My energy levels have remained high ever since dose one. I still remember myself a year before starting and even 4 years back. I was dead tired after work, hard to stay focused on anything mentally and lethargic. That is no longer the case and my new norm is lots of energy and focus, and I can stay up till 2 am if I want.

 

My current regime is 25x 100mg tablets. I will do this for 3 days. The main thing is I noticed no side effects. A little jitterness in the first few days when doing a treatment and then that goes away. I was worried about my hairline but it does not seem to have a lasting effect though I suspect if you dosed constantly it could so something there. All in all I suspect this is effective in humans just as in mice, but we have to look 2 years out to see results and then compare ourselves to our no longer existing former selves who did not take the treatment. 

If there are any questions for me I can answer. I will say this, fisetin works, it's safe, and likely it does exactly what it does in mice, only in humans. Fairly exciting stuff.  

Carl D

 Thanks for sharing.   So you did not use piperine nor mix the fisetine with oil or cream?