Should we be taking oral NR/NMN?
In the YouTube video post I have a new one with David Sinclair with a few interesting tidbits. One is that NR/NMN, if not kept cold, degrade into a form which you definitely do not want in your body (he didn't specify exactly what the issue was). Collaborating this, the NAD+ patches I take from MedLab Pharmacy comes in a cold package and is specified to be stored in the refrigerator. The one I got from another pharmacy - I forget the name but it's in the MidWest, did not and it turned brown after a month or so.
This makes me wonder if we should be doing oral supplementation at all, why not just a semi regular protocol of patches? Is the oral form kept chilled at the distributor (no - LE has no mention of this AFAIK) and it's not sent chilled to us. It's also quite expensive, so it seems to me that perhaps a better approach is to just do without it.
From the Dr. Rhonda Patrick podcast notes are further details:
(See https://podcastnotes.org/2019/11/06/david-sinclair-rhonda-patrick-nad-nr-nmn/ for completes notes of this podcast)
* “Make sure your NR and NMN is kept in the cold. If it’s just on the shelf, and not in a stabilized form, it will degrade into nicotinamide, which is something you don’t want to take high doses of.” – David Sinclair
* Why? – Nicotinamide actually inhibits sirtuins, thus interfering with DNA repair
Also from the same podcast notes:
NAD+ Boosters | NR and MNM
* For background, humans make NAD+ from a variety of natural molecules. However, you can also supplement with NAD+ precursors (and it might be a good idea to as NAD+ declines with age).
* (Why not just supplement with NAD? – It’s too large of a molecule and cells won’t uptake it)
This last statement about NAD - I have heard David Sinclair say this more than once during his public presentations and interviews.
New here... I use Tru Niagen and the question of refrigeration was asked on their FB page. Their response was:
Hello Mike, TRU NIAGEN® does not need to be refrigerated. That’s because Tru Niagen® is formulated with a crystalline form of nicotinamide riboside chloride. This crystalline form is shelf stable stored under the recommended conditions listed on the Tru Niagen® bottle. ChromaDex specifically formulates our products to enhance the overall stability and quality. We also conduct our own internal testing and development to ensure the bottle contains what is stated on the Tru Niagen® label. Thank you
I asked the help desk at Genex. Here's their reply:
I think you may be asking this due to the recent interview between Ronda and David. In regards to the NMN cold question, NMN in its raw form is vulnerable and must be kept in a freezer or cold storage. The NMN raw material we use is kept in cold storage all the way up to production. Once the production is completed, it is now stabilized and protected from moisture and light. The product is then kept in a climate-controlled environment. If you listen to the discussion, Sinclair is talking about NMN that if not in a stabilized form, degradation of the product will occur. However, once production is completed, it is then stabilized and protected from light and moisture and has a good shelf life of about 2 years (as long as kept in a cool dry place). Once the bottle is open however, it is now exposed and can start degrading. This is usually not an issue though since the product is a 30 day supply and degradation during that time is minimal. The biggest issue with NMN degrading has to do with moisture, which can cause NMN to breakdown. NMN will hydrolize over-time so it is important to protect it. We include a moisture pack in all our NMN bottles to protect against moisture, and our bottle is opaque, which protects against light. That said, you can store it in your fridge or freezer once you open it if you are more comfortable.
I started to take NMN powder sublingually. I noticed it has acid taste. Since NMN contains a phosphoric acid residue it has acid pH. I also remember that some time ago dentists used 30% phosphoric acid to prepare dentin surface. Phosphoric acid has very strong detrimental effect on teeth. So my question is do you think it is safe FOR TEETH to take NMN sublingually?