Should we be taking oral NR/NMN?
In the YouTube video post I have a new one with David Sinclair with a few interesting tidbits. One is that NR/NMN, if not kept cold, degrade into a form which you definitely do not want in your body (he didn't specify exactly what the issue was). Collaborating this, the NAD+ patches I take from MedLab Pharmacy comes in a cold package and is specified to be stored in the refrigerator. The one I got from another pharmacy - I forget the name but it's in the MidWest, did not and it turned brown after a month or so.
This makes me wonder if we should be doing oral supplementation at all, why not just a semi regular protocol of patches? Is the oral form kept chilled at the distributor (no - LE has no mention of this AFAIK) and it's not sent chilled to us. It's also quite expensive, so it seems to me that perhaps a better approach is to just do without it.
From the Dr. Rhonda Patrick podcast notes are further details:
(See https://podcastnotes.org/2019/11/06/david-sinclair-rhonda-patrick-nad-nr-nmn/ for completes notes of this podcast)
* “Make sure your NR and NMN is kept in the cold. If it’s just on the shelf, and not in a stabilized form, it will degrade into nicotinamide, which is something you don’t want to take high doses of.” – David Sinclair
* Why? – Nicotinamide actually inhibits sirtuins, thus interfering with DNA repair
Also from the same podcast notes:
NAD+ Boosters | NR and MNM
* For background, humans make NAD+ from a variety of natural molecules. However, you can also supplement with NAD+ precursors (and it might be a good idea to as NAD+ declines with age).
* (Why not just supplement with NAD? – It’s too large of a molecule and cells won’t uptake it)
This last statement about NAD - I have heard David Sinclair say this more than once during his public presentations and interviews.Reply