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Re: DNA Methylation Testing Recommendations Sought
@Paul Beauchemin I was not happy with https://www.mydnage.com/ because they ask your age. Thats an open invitation to dry lab results.
- Fred_Cloud
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: wrinkle reduction
I just ran across this article by the rapamycin guru blagosklonny trying to patent topical rapa back in 2007, clearly ahead of his time, its an interesting read so I thought I would pass it on.…
- Fred_Cloud
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Rapamycin nasal spray for the brain?

Has anyone tried snorting rapamycin? intranasal rapamycin reduces oxidative damage in the brain to prevent alzheimers, Parkinson disease and other brain aging disorders.…
- Fred_Cloud
- 4 yrs ago
- 2replies
- 152
- 2
- Rapamycin Discussion
Re: Fisetin to Clear Senescent Cells
@garland No, it doesnt interfere with the effects of fisetin, that is not the concern. Rapamycin can suppress sasp like fisetin so you wouldnt be able to tell if it is the fisetin reducing sasp or…
- Fred_Cloud
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: wrinkle reduction
@Michael I have been taking 3mg rapa weekly and using the topical rapa for 2 months and I havent noticed a difference yet in my skin. But I am not panicking yet because @Paul Beauchemin mentioned he…
- Fred_Cloud
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: wrinkle reduction
@Michael So you mixed in 4mg into 4 ounces of cream? I know it seems like a weak formula but people are getting results, granted it takes 2-3 months though.…
- Fred_Cloud
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: wrinkle reduction
@garland Do you have any before after pictures?
- Fred_Cloud
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: DNA methylation test
@MAC Seriously? You want me to keep trying? It sounds like you are trying to make a good case of why you dont want to take it. All I can add is that early life interventions often payoff way later…
- Fred_Cloud
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test
@MAC Impressive, probably no need to take it yet then. Well then what is your interest in this group if you dont need to reverse your age? Usually people in here are feeling their age.
- Fred_Cloud
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test
@MAC Not for me, rapamycin offers so much more than adding a few years onto to your lifespan, so much so that I actually dont care if rapamycin extends life or not I would still take it.…
- Fred_Cloud
- 4 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: DNA methylation test
@MAC So stretch out the interval to 10 days or longer and it wont be an issue. Also, research is coming out that it can rewind the clock, you could always use it short term and rewind the clock and…
- Fred_Cloud
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: DNA methylation test
@MAC Have you considered taking rapamycin?
- Fred_Cloud
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: Paul's self experimentation
@Paul Beauchemin rapamycin alone has been shown to reverse methylation age. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555449/
- Fred_Cloud
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin retards epigenetic ageing
Has anyone been able to verify through testing that they reversed their methylation age from rapamycin?
- Fred_Cloud
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
How much autophagy with rapamycin

How many hours or days do you think are in autophagy when taking weekly rapamycin? Just based on half lives, do you think it is 2 days or is it much longer?
- Fred_Cloud
- 4 yrs ago
- 4replies
- 253
- 1
- Rapamycin Discussion
Re: Senolytics
@Michael I would just source it from one of the several places everyone is getting it here and you can also make the face cream yourself very easily. I crushed up 3 tabs and put in a bottle of…
- Fred_Cloud
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics
@Mark Thimineur How about whole body application? I decided in addition to applying it daily to face that I would also apply it once a week to my whole body.…
- Fred_Cloud
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics
@Michael Yeah, he is getting old. So what is your plan B for rapamycin? There are other docs that will prescribe it if that is what you want. I didnt use a doc and just sourced it myself and started…
- Fred_Cloud
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Senolytics
@Mark Thimineur Thank you for your thorough response. I have followed your directions and made up a 25 micromolar concentration and have been using it for a couple of weeks already I just figured if…
- Fred_Cloud
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@JGC Well it could have lowered it, I have no idea, I only checked it after being on it for 10 months. like I said, I didnt check my methylation age before I started so I have no frame of reference,…
- Fred_Cloud
- 4 yrs ago
- General Discussion
- Reported - view
Re: Senolytics
@Mark Thimineur Thanks for your formulation help. Could you use higher concentrations but then use it less often say weekly? what would be the upper limit of safe?…
- Fred_Cloud
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@JGC I agree, methylation age is the best data. ai based on cbc blood lab is a poor mans gauge. I have been on gdf11 for a year, I checked my methylation a couple of months ago and it wasnt lower…
- Fred_Cloud
- 4 yrs ago
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@yz This inside tracker thing he is discussing looks like nothing more than an algorithm like aging.ai website that you can run for free.
- Fred_Cloud
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@JGC Looks like this other video confirms that he did say "actually I was" tested at age of 60.
- Fred_Cloud
- 4 yrs ago
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@JGC He didnt say "Lets say that I was" he said "actually I was" meaning that was his actual test results showing methylation age of 60. It is confusing as as first he was speculating a hypothetical…
- Fred_Cloud
- 4 yrs ago
- 1
- General Discussion
- Reported - view

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