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Re: Rejuvant? @Larry I"ve been using Rejuvant and Rapamycin for the past 4 months... no issues. But would be really nice to see all the permutations and combinations of common age-mitigation drugs and supplements…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- General Discussion
- Reported - view
Re: Richard Miller on Peter Attia podcast regarding rapamycin @Van Van - all these medicines are easily and inexpensively available via vendors on indiamart.com and I"ve had no problems getting them delivered in California.…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: The Science on Rapamycin for Skin - 2 papers - Your Thoughts? @Michael Here is some coverage on that from the first research paper: https://link.springer.com/article/10.1007/s11357-019-00113-y/figures/3 I've used Rapamycin cream I used myself - at .…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
The Science on Rapamycin for Skin - 2 papers - Your Thoughts?
There have been two papers I've seen that have focused on rapamycin's topical for aging skin See links below. The second study was comparing it to a proprietary peptide,…
- Brin Chikovski
- Brin_Chikovski
- updated 4 yrs ago
- 5replies
- 292
- 1
- Rapamycin Discussion
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin @Brin Chikovski Price is typically around $1 to $1.25 per 1mg tablet.
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Update on two dogs profiled in a 2016 CNN post about Rapamycin Folks - its very easy to get Rapamycin, just search on indiamart.com for vendors, and purchase a version of sirolimus / rapamycin from a somewhat proven Pharma company.…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Who Else taking Acarbose for longevity? In studies conducted by three independent laboratories by the US National Institute on Aging's intervention testing programme, acarbose was shown to extend the lifespan of female mice by 5% and of…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Who Else taking Acarbose for longevity?
I started taking Acarbose about 6 months ago after reading the ITP studies that showed a that it and rapamycin are the only two drugs approved for human use that have been shown to significantly…
- Brin Chikovski
- Brin_Chikovski
- updated 4 yrs ago
- 3replies
- 455
- Self-Experimentation
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @Pablo Reinaldos López The protocol for taking acarbose is that you take it with the first bit of food for a given meal. Details here: https://www.healthline.com/health/acarbose-oral-tablet
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @Pablo Reinaldos López Pablo - I don't think the research has been done yet to tell us if 1mg or 5mg is better. Its all a guesstimate right now...
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @Jim N I do try to follow a low carb, keto diet, but I'm not perfect so I think the Acarbose helps. Its interesting - the Acarbose side effects (mostly just gas) really varies by food you eat...…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @Pablo Reinaldos López Good point - I think the data we have now is that 5mg/day and lower is pretty much risk free from this summary: https://www.alzdiscovery.…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @aribadabar said: the correlation to biological age is about 65% , not 94%, as Michael posted, so it is a very tough estimate Thanks - I Believe the LifeExtension tests cover those: https://www.…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? No, no significant changes in diet or exercise while ramping rapamycin. after losing about 15 or 20 lbs I did start exercising more, in part because it was a lot easier and my endurance was much…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? I've been using rapamycin for over a year now. I started with 1mg, then increased it by 1mg each week until I got to 10 weeks. Then after every "rapa vacation" I restart at 6mg without problems.…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? @Brin Chikovski So - 10mg rapamycin, done in one dose/week. Acarbose is 100mg every meal (with first bite of meal).
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? Ah - sorry, that was confusing how I worded it. I take 10mg, in one dose, once per week. And Every 4 or 5 months I take a 6 week rapamycin vacation/ break from taking it to keep the MTOR2 pathway…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? Pablo, I already take 10mg of Rapamycin and 100mg of Acarbose with every meal. There have not been any longevity studies yet in humans using lithium. Generally the medical establishment seems to…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet? Mark, thanks for that information - very helpful. JGC - thanks - but I'm much more comfortable with the lithium chloride or lithium carbonate versions of lithium as that is what all the research…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
I've been reading the research on how low-dose lithium looks to be helpful in age mitigation as outlined in links below. I want to try it at the level of 5mg to 10mg a day.…
- Brin Chikovski
- Brin_Chikovski
- updated 4 yrs ago
- 28replies
- 453
- 1
- Self-Experimentation
Re: How much autophagy with rapamycin A recent study on autophagy - too much is harmful: https://twitter.com/jpsenescence/status/1334152103451877376?s=20
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: How much autophagy with rapamycin The good news is that a new blood test has been developed to actually measure the level of autophagy in the body. This will finally help us understand our levels of autophagy and compare it to the…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin @Brin Chikovski and https://twitter.com/Blagosklonny/status/1297671178484625408?s=20
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin @Ross Barker I will be going in for blood work very soon - so I can't answer your question right now. What I have read is that all the side effects that rapamycin can cause,…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"? @Paul Beauchemin Paul - how exactly do you measure these two items: reaction time grip strength and what is "FEB and PEF"? I like your list. I'm currently looking at the PhenoAge panel - An analysis…
- Brin Chikovski
- Brin_Chikovski
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view

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Brin Chikovski

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Joined: Sun Oct 27 21:25:41 UTC 2019

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