Details of dasatinib + quercetin study

David Michel Begin my second round of D+Q this morning, one hour ago.  Took on an empty stomach so the dosage does not compete with other nutrients or drugs.

David Michel Day two of the second round of D+Q.  The second round has been much easier than the first round.  I had no symptoms other that a mild headache which resolved with a 500mg aspirin.  I had to chills or fever. Second day feeling normal.  I think the first round must have removed a number of Senescence cells that were sensitive to D+Q so by the second round there probably were not a lot to remove.  This makes me think if studies say the D+Q combination only remove 1/3 of Senescence cells the remaining cells must require another protocol. 

David Michel I had no fever or chills.

David, at 76 do you  have now or in the past had any joints with arthritis?  You are one of the best self testers on this site. I am 70 and use metformin, fisetin, aspirin, quercetin, coq10, and a few other hard to remember named supliments. I am considering rapamycin and dasatinib when I can get script.

Second question, have you heard of any rapamycin users who have reported cataracts, or testecular atrophy from intermitant  rapamycin use? 

are we there yet  If I have any arthritis it is very slight, occasionally I seem to have positional postural stiffness, and have had some idiopathic peripheral neuropathy  which seems to have not been hurt or helped by my testing. 

You don't need script to order out of the country.  

As to  any side effects of Rapamycin, I am taking Sirolimus which is another name for Rapamycin.  I have been taking it for two years.  I have made the following observations:  About 6 months into taking 6mg weekly, I developed idiopathic nausea and vomiting.  Doc's could find no reason for this, however I stopped taking rapamycin for 3 months and resumed at 5mg  every two weeks ,as I take a lot of things that reduce MTOTC1. There have been some report of stomach problems associated with Rapamycin thinning  mucous membrane and this may have been the cause of my nausea and vomiting, but who knows.  It has not returned.

It is frustrating to me that I cannot find a local doc who will monitor for me, however to stop, in my opinion, is like being in an airplane headed straight toward the ground with no pilot and failing to try to fly the airplane.  Time waits for no man and at my age I do not intend to sit idly by and pontificate on why I should not experiment.  I wish that I had unlimited funds to test my results but I will not let that stop me from searching for a solution to slowing aging.   

David  Thank you. I found a local Dr. in Houston that will likely give script for sirolimus next monday. She was very intrigued by dr.Alan Greens website but wanted to read more before writing script.  So I will likely add Rapamycin to my experimentation. First I want to do a new full lab panel and aecho cardio  for cardiac ejection fraction for a baseline for later reference.

I am 70 and agree with you David, that at our age , wise experimentation is better than waiting for finished studies.

djmichel  Hi   I