Details of dasatinib + quercetin study

Ozone8  I read the study and it seems that AUC, (the area under the curve (AUC) is the definite integral in a plot of drug concentration in blood plasma vs. time.)  This would mean taking Dasatnib with a meal that has a fat content of approximately 50% would result in a 15% greater concentration of Dasatnib in the blood.  So I surmise that the instruction of taking on an empty stomach is to  insure that the blood concentrations do not exceed the calculated dosages.  As to limiting exercise it is probably due to some studies that indicate the Dasatnib can cause Pulmonary  Atrial Hypertension.  Exercise with Dasatnib may exacerbate Pulmonary Hypertension due to increased Pulmonary stress, so waiting a week for Dasatnib clearance is probably recommended with due caution.   https://erj.ersjournals.com/content/48/suppl_60/OA262?utm_source=TrendMD&utm_medium=cpc&utm_campaign=_European_Respiratory_Journal_TrendMD_0

Ozone8 As far as I know the rules were determined by some study that I have no data on.  I suppose you could take a fatty meal, but why,  I have just followed the Life Extension protocol and everything has been ok.  So I take according to my weight, fast, and abstain from exercise for a week.  No problems so far. getting ready for the second round.

@djmichel   I find your postings useful and inspirational.

I just received my order of 1 kg of rapamycin and 10gms of dasatinib in powdered form from China.  I will have them analyzed before I use them.

I have been on Metformin 2 gms per day for about 8 years, since I noticed my morning glucose level was around 110.  Low-carbing, Metformin keep my A1C about 5.3.  Just added Acarbose for those times when I have no choice and have to consume a few carbs (my 65th birthday, e.g.). It is pretty great, once one gets used to it.  Does a good job of mopping up French fries and whole grain bread.  Quercetin, Pomegranate Extract, Boswellia, all seem to keep my PSA around 2.7, (which has increased about 1 over the last 10 years), though admittedly, my prostate is about twice as big as it should be.  Dad died at 83 from PC.  I also take Telmisartan, Nebivolol, and Amlodipine for BP, Tadalafil and Alfuzosin for BPH. 

I've recently done the Mayo Clinic Fisetin protocol about three times, using a bit higher dosage than the "frail old ladies."  And I also stacked on some high doses of intermittent Azithromycin.

So, Blood work:  I have noticed some abnormalities over the years and they have concerned me, because there is just no possible benign reason for them.  Total Serum protein is 60 (should be at least 66), normal albumin, so I guess the globulins must be a bit low overall.  Leukemia, anyone?  Atrophied thymus maybe?  Except the numbers all taken separately are normal to low normal.  The monocytes percentage has been as high as 12.5%, though the absolute numbers were .7 before I did the Fisetin.  Now, it's .5 and 10%.  PSA dropped to 2.3.  EGFR improved.  FGL, too.  I also take a 10mg Lipitor daily with 2 grams of instant release Niacin, ever since my doctor told me about 12 years ago that I was starting to build up some plaque in my carotids (about 33%).  That's apparently now down to 25%.  That's because my regimen boosted my HDL almost to the same level as LDL, and TG are almost not there.  The only worrisome thing is my D-Dimer which has been as high as 2000 and now is back down to about 1300, when it shouldn't be over 650.  I've been checked out for everything, every kind of cancer, pulmonary thrombosis, DVT, etc.  Nothing.  Clean stress test, too. I'm on TRT (Nebido).  It isn't cheap but seems to work well with few side effects.

My doctor tells me not to worry about blood tests so much, that I'm a bit of a hypochondriac and questions why I take so many vitamins, etc.  (German doctors hate that stuff).  I fly to Ukraine and buy most things without a prescription.   I also lift three times a week, and keep my 45 year old wife drooling over my six-pack.   Just did a 4000km motorcycle tour through Eastern Europe last year with my 11-year-old son and am doing it again this year with my 12-year-old daughter on the back.  Grueling?  A bit.  I can do 100 sit-ups and 50 push-ups if I REALLY have to.

If I have one real worry, it's that I've from time to time awakened from a dream with slight movement and fear RBD and the almost certain Parkinson's that'll come eventually.  For that reason, I take 5 mg of Selegiline a day.  The Hungarian doctor who invented it sold me on it.  That and Melatonin (15mg each night) seem to have kept it under control.

Nobody cares about you and your health more than you.  Getting old ain't for sissies.   See you around the pool.