Treatment for Reducing Arterial Plaque and Imflammatory Cells:

Paul Beauchemin Bob, could not disagree with you more.  On berries and fruits,  I reference you to Barry Sears books  "Mediterranean Zone and Resolution Zone" and  the need for polyphenols. Only way to get the amount you need is with berries and fruits, unless you drink~10 cups of coffee.  Also, multiple studies from Rush University and others document benefits of  including berries/nuts etc in diet. I tried a vegetarian diet with fruits and berries--not a lot-- and without my statin and and fish oil I would be on the other side getting reprogrammed for a new life. My HOMA score is 1.44. My TR/HDL ratio is one when I am not experimenting, and as you agree, this is one of best evaluators for health.

I also insist on my fermented milk products for the benefits to the microbiome (really big deal right now).  I prefer these to fermented vegetables  because of the protein content. I try to get 70-80 grams of protein per day (1 gram/kg) as suggested for seniors to prevent sarcopenia. I am primarily Norwegian and am not lactose intolerant. I also eat two slightly green bananas/day  for the prebiotics.

We are all different-- there is no universal diet that  applies  to all of us for maximum life extension. If you were to compare median life expectancy on your diet to those on the SAD diet, those on your diet would live  of 10 - 15 years longer. However, a significant number of individuals on your diet would die prematurely, while a significant number of those on the  SAD diet would out live the average person on your diet.  In an earlier E-Mail, I referenced my father-in-law who lived to 97 and ate meat and potatoes 3X per day. His wife died from melanoma at 62.  She would probably have survived today with the new cancer treatments ( See Jimmy Carter).

My father-in-law broke his hip at 93 and spent the last three years of his life in a bed in a nursing home. Was there a testosterone deficiency that resulted in osteoporosis?

I was personally  enthralled with the possible health benefits of the 5:2  and 16-8 diets. I was on these for the past 2 and 1/2 years.  An analyses of my blood work attached to yesterdays E-Mail to Randy indicated the diet increased my cholesterol, reduced my testosterone by 50 % and  increased my WBC.  Surprisingly, my anemia disappeared in contravention of all that I know about testosterone and anemia in senior men. However, I stopped the diets and returned to a 12:12 diet period.

As I suggested to you in a previous E-Mail, maximum life extension in my opinion is a multifactoral undertaking. It requires vigilance on a number of fronts. I have not seen, for example,  any discussion about hormones, pro and con. I am the only one who has brought up fish oil despite the LEF's long standing incorporation of this supplement in it recommendations along with several thousand peer reviewed papers.  

I am now excited about fisetin and started the Mayo protocol after someone on this site brought my attention to the risk assessment in Forever Health.

Paul, If you it his far,thanks for the effort. Had to get it off my chest.

BobM Bob I am prediabetic.  Offer the following to get most of everything you need  to start the day and it is delicious:

It is a smoothie with following ingredients and amounts. Unless noted I buy everything at Costco.

In blender blend  

1 cup (225 grams) low fat yogurt  ( mine is home made)

1 cup (140 grams) Wymans Frozen WILD blueberries (  yields ~1.2 grams of polyphenols if truly wild  and about twice the amount in farm grown)

 28 grams frozen almonds

40 grams Gold Standard whey protein isolate

10 grams Hersey sugar free cocoa ( yields ~ 300 mg polyphenols, cannot buy this at Costco)

Note that the protein in the whey will blunt the sugar spike from the unfermented lactose in the yogurt and sugars in the blueberries. You get your  probiotics in the yogurt. The blueberries and cocoa give you the anthocyadins needed for neurogenesis to go along with the fish oil you are taking.  Check you blood sugars after you try and let us know . 

Whey protein will boost your immune system. It is food of choice for those with HIV. You can verify with google search, and Life Extension has written several articles on its benefits. These include lactoferrin, immunoglobulins and cysteine to increase glutathione.

I see you belong to Consumer Labs and you can note that almost all cocoas exceed the California food  safety standards for cadmium. If you keep your consumption to 10 grams per day you will not exceed European weekly amount considered safe. 

A note of caution if you are taking metformin. In my case and supported by the literature, if you check, metformin ( as well as calorie restriction) will reduce your testosterone. Suggest you have your blood checked.  

Good luck and wish you the best..

BobM Forgot to ask. Are you taking fisetin? Saw your name on the section on this topic. I started in June and found it to be unbelievable in terms of improving my color vision and strength. Will do blood work in early Sept. 

@Peter H. Howe  Peter, I am very curious about how people use fisetin. And nice to hear that fisetin works well for you. Can you share how you use fisetint? Intermittently as  a senolytic and/or continuously as geroprotector?

Staffan Olsson Steffan, I became aware of the benefits of fisetin by following the fisetin thread on this forum. A key input was information and risk assessment  on the "Forever Healthy" website that come to my attention from one of you. Thanks.

I will be 80 in Oct and am hoping for some senescent cell removal benefits as studies indicate that it will remove 4 of the 6 different cell types. Do you know of any analytical method to document senescent cell removal ?

The literature also indicates that it will reduce cholesterol, increase insulin sensitivity and has other benefits, so I am also looking at it as a geroprotector.  

 In terms of my treatment protocol, I started in early June of this year and take 1.5 grams of the Swanson's product on two consecutive days twice per month, except in July when I only did one.  Basically I doubled up on the Mayo frequency with the amount equal to Mayo  20 mg/kg body weight daily dosage.  I take it on an empty stomach and do not eat for 3-4 hours afterward.

I will do an extensive blood work up at Lab Corp through LEF in early Sept. I did extensive blood analyses in mid May through LEF.  Will report the results. 

 As I reported previously, immediately after my first treatment colors (not my vision acuity) became very enhanced/vivid.  My strength increased significantly. I increased my chinups from ~ 20 to 26 and increased my pullups from ~ 22 to 28. The increase in strength and more vivid colors  continues. This has to be due to more than senescent cell removal as the benefits were almost instantaneous. Others on this forum have also reported similar benefits.

I suspect that fisetin my be the "real deal".

Staffan Olsson Staffan, forgot to mention in previous response that literature indicates fisetin is also mTOR 1 inhibitor and activates AMPK. Please include these benefits in its value as geroprotector.

BobM Thanks.

Peter H. Howe Peter.

I am happy you find Fisetin useful. I do to. some seem to have the idea that you can benefit from fisetin in different ways.

One way is to use the procedures that most of us seem to follow - to take fisetin intermittently and in very high doses for 2-3 days. This with the goal to eliminate as many senescent cells as possible. I do so.

The other way would be to, besides the above protocoll,  include fisetin in small doses every day. Like 200 - 300 mg per day. This with the goal to protect out bodies from processes that slowly destruct the brain and from other degenerative processes. Processes that are not (only) related to the removal of senescent cells.

I am not doing the above kind of intervention myself. At least not yet. Unfortuantely I lost the reference to the research that indicated that fisetin could have other positive effects besides the removal of senescent cells. If I find it I post it here in the forum.

@Staffan Olss See attached. First is the Forever Healthy website which includes a Risk Assessment  for fisetin with multiple sections focused primarily on senescent cells and Mayo Trials. You may have this. You have to scoll down to get to it. 

The second is from a world molecules website and has some details on other benefits. This includes a section on mTOR inhibition which I found extremely interesting. 

https://www.forever-healthy.org/home.htmlon 

https://www.worldofmolecules.com/anti-aging-and-senolytics/fisetin-molecule.html

Note that both websites have numerous articles, summaries and  risk assessments on other "antiaging" compounds we frequently encounter.

On AMPK stimulation and other benefits I mentioned you can google. Most are focused on rats and other organisms. 

I am very excited by fisetin. 

Hope this helps

Peter H. Howe  Thank you for the reference to World of molecules. it indicate that fisetin might useful in more ways than acting as a senolytic compound.

BobM 

Thank you very much BobM. Of course don't have a prescription so I hope it'll work I hope that I can get ahold of some from dropshipMD.

Regards 

BobAlgie 613-829-2722 on WhatsApp

BobM  Hi bob, If you wouldn't mind can you tell me (us) what you paid for your Rapa and Dasatinib? I'm always looking to stock up on my supplies.

BobM Thanks

BobM Oh, you were able to purchase from theantiaging store in march? They been out of stock on both rapa and dasa for a while. I keep rechecking but such luck yet.