Treatment for Reducing Arterial Plaque and Imflammatory Cells:

BobM  The optimal dose of MK7 for reversing arterial calcification is approximately 380 mcg/day. This is based on studies examining how much Matrix GLA  Protein (MGP) is activated in response to a dose of MK7.  

BobM Thank you for the info. Good luck. If you have info let us know what happens to your Tri/HDL. I  have two  family members who would not here today without Mayo- Rochester Mn. They had neurological problems.

LEF has article in August 2020 Mag on fish oil, yet to be published.

The Vit K suggestion I believe came from Randy. I was unaware of its benefit, as well as EDTA for plaque . I learned something. Good thread here.

Staffan Olsson I have done about 75 edta chelations. After all of my experience and studying I have come to the conclusion that it is not the calcium that is being pulled out that makes it therapeutic. It is the preservation effect on the blood making the red blood cells soft and pliable reducing the scraping or scoring effect on the endothelium like a diamond cuts glass, hard enough rbc's cut the artery, then it heals with scar tissue which narrows the artery which makes it more prone to pressure increase at the narrowing which rescores the endothelium which then causes more scar tissue and presto you have artery narrowing. No one will tell you this, most chelations docs dont even know this, they just know it works so they don't bother looking any further into it. EDTA also removes iron which is also the other half of the equation to its benefit. Iron or ferritin is toxic and caused oxidative stress and damages the endothelium. You can donate blood to mimic the effect of chelation which removes ferritin from the blood and forces your body to make more rbc which are young and softer and more pliable and easier on the artery wall.

Fred Cloud Thank you for your response. I wonder if you can share your experiences of edta chelations. After 75 chelations your personal experience and the health benefits of the treatment is very interesting. ?

Staffan Olsson I think the whole heavy metal removal theory is not the whole story. I had high ferritin and I think the chelation was helping compensate for it, it can pull the iron out of the endothelium and thin the blood and make things better for a while. If you think about it, most of these old timers that were getting chelation were men, men build up ferritin. I also was exposed to alot of lead as a child so I was trying to get rid of that. Dr Blumer who ran a study found it reduced heart disease and cancer deaths by a large amount, well that jives with the benefits of blood donors. It used to be very popular but you don't hear much about it anymore, have you ever done chelation? I think donating blood is going to get you similar results. If you wanted to do IV therapy for your heart I would recommend IV Plaquex. It is phosphatidylcholine and a bile acid that dissolved cholesertol out of the arteries. I have done that too, some chelations docs would alternate back and forth.

You can find docs who do it, it is also known as IV PTC, IV plaquex, IV PPC

https://youtu.be/ZnUMf__pwGY?t=20

Fred Cloud Thank you Fred. I do other interventions for now, but any progression in the field of plaque reduction is very interesting to me.

BobM 

Here is another perspective on how to reverse atherosclerosis.

There is research aiming at reversing athrerosclerosis by resetting the microbiome. They have done it successfully on rats. But it is hard to translate into humans. But it is a another confirmation of the importance the gut and its microbiome has for wellbeing and good health.  

https://www.lifespan.io/news/reversing-atherosclerosis-by-resetting-gut-bacteria/

Staffan Olsson You may want to ask @garland  he has had 50 of these plaquex treatments.

BobM  Instead of me writing up a big explanation I've attached a link. This guy does a pretty good job of describing the importance of LDL-P (with references). The Medical Journals are full of studies confirming what he says, and that is.. LDL-C is not a predictor of heart disease but LDL-P is. Doctors just can't get the brainwashed heads to accept the data. But then again, if you had a drug dealer show up to your office every week and offer you free samples of the latest LDL-C lower drug wouldn't you want to give those out to your patients too?

https://chriskresser.com/the-diet-heart-myth-why-everyone-should-know-their-ldl-particle-number/

Paul Beauchemin You and others have missed my point on LDL-C. It has value as a trend marker on the lipid profile. I agree that LDC-P is superior, but I do not need one of these any longer and do not wish to incur the additional cost. As indicated in my previous comment to BobM above, I had bypass surgery 26 years ago, and the probability of me being alive 26 years later or not having another is less than 5 %. I referenced a Dr. Davis who worked out for me integration of a statin  (Lipitor)and fish oil to minimize my risk. His blood work depended on a VAP test which includes a LDL-P test. In my case it was the fish oil that resulted in the non inflammatory large LDL particles as measured by the LDL-P test in the VAP test. 

In my initial comments to BobM, I suggested that he do a  VAP test after experimenting with fish oil. I also suggested he measure his progress with a carotid intima test (CIMT). I do one of these every 2 years, and with one exception over the past 20 years, there has not been a plaque increase.

I agree with you on the triglyceride/ HDL ratio as an important biomarker to evaluate the possibility of heart disease and also suggested that BobM look at this ratio. According to Barry Sears as well as Dr. Davis, this is probably one of the best biomarkers to indicate cardiovascular problems and fish oil dramatically lowers the ratio ( at least in my case and references in the Sears books) due to the fact that it reduces triglycerides. Sears, as I recall, recommends 2.7 grams of EPA-DHA as a starting point. Dr. Davis started me on 4 grams (over the counter) and I continue with 5 grams today. 

 This brings us to value of LDL-C and lipid profile without a LDL-P test to me. On my last blood test my LDL-C increased to 87 (from~75-80) and my TotalC/HDL ratio  (also good marker) reached 2.8 from about 2.5. This ratio indicates that I am in good shape in terms of not having an ischemic heart attack, but I am not taking any chances and increased my lipitor.  I will do a chemistry profile, CBC and lipid profile in September. I have numerous uncles-great uncles who passed due to heart attacks in their 40s, 50s and 60s. As indicated by the Dr. in the Crestor film, genetics plays a large role in whether or not we have cardiovascular  problems. If you go through the 1,000s of papers on statins, you will find that about 35 % of us need a statin. I will be 80 in October, and hope to make it anther 10-15 healthy years.

Based on BobMs stent history, he needs to be extra vigilant. Each of us is different. You can generalize but a lot of us will die as a result. I had a father in law who passed several years ago at 97. He was a beef farmer with a feedlot in NW Illinois. I don't think he took a pill until he jumped off a tractor and broke his hip at 93. He ate meat and potatoes 3X/day and if you said anything about that lifestyle being unhealthy -"God Help You". I was within a few days of a heart attack at 54 following the same lifestyle.

I will leave discussion about the benefits of fish oil for anther day.

I love this site--- just started fisetin following Mayo Protocol after reading about it here and being forwarded to the "Healthy Living" risk assessment. As reported by others, I saw immediate results and will report out after my blood work in Sept.

Thank you everybody.

Peter H. Howe Good info Peter, do you manage your ferritin levels at all? This is a fascinating article on the role of iron.

http://nautil.us/issue/67/reboot/iron-is-the-new-cholesterol

Fred Cloud Fred, thank you for your comment and interest. My response will only increase confusion on cardiovascular issues-- but here it is:

I am severly hypogonadal and have been supplementing with androderm ( patch) for the past 20 years. If you read the early LEF literature ( see LEF's "Disease Prevention and Treatment") they reference the fact that some anemic individuals have lower levels of testosterone. This results in a a feedback mechanism to increase cholesterol and thus testosterone as testosterone is made from cholesterol after cholesterol has  been converted to pregnenolone etc. It has been shown, for example, that treatment with chlomazine, a gonadotropin stimulating hormone agonist which increases lutenizing hormone and thus testosterone, results in a decrease in cholesterol. With this short background I was always anemic prior to my bypass, and continue to be anemic occasionally.

I actually supplement with iron sulfate at 325 mg 3X per week. My iron was only 84 ug/dL  ( range 38-169) and my ferritin was only 50 ng/ml ( range from (30-400) based on my last blood test.

My total testosterone on my last blood test was only  197 ng/dl ( normal range is 264-916).

The interaction between totol T, free T and DHEA would take several more paragraphs, but simply put,  if you supplement with DHEA, the amount of free T increases from 1-2 % to 3-5 % which bring free T within an acceptable range.

Note also that metformin as well as calorie restriction will decrease total T. Apparently the increase in AMPK from either treatment is telling us that now is not the time for sex. 

I will end again with the statement that we are all different and it is unlikely that a single treatment, except for a statin plus fish oil, will solve a cardio problem for some of us.

Peter H. Howe sorry Peter, I totally disagree 

LDL-c is extremely bad as a trend tracker. It has zero correlation with the outcome we seek, that is, increased lifespan. 
 

It can do great harm if people use it to manipulate statins.

only sdLDL is important. 
 

I think the Lipid Hypothesis is flawed, but if someone buys it, at least be willing to pay a few extra $ to get a lipid subfraction 

Paul Beauchemin Disagree again. As I have said repeatedly, I did the LDL-P under Dr. Davis's care several times twenty years ago until he got my lipid profile where he wanted it as he treated me with a statin and fish oil. Referring now to my lipid profile with some emphasis on LDL-C is all I need until something goes wacky. As I have indicated several times, I also use the TG/HDL ratio  which has been around as a biomarker for over 20 years. This marker is profoundly influenced in a positve manner by fish oil and a statin. In my last blood test, there was a small  increase in LDL-C, Total C and TG/HDL ratio.  All of these values were in acceptable range. However, my  cardiologist doubled my stain because of my history.

I just recently, on my own initiative, returned to my previous statin dosage as I want to see what happens on the Mayo Fisetin treatment protocol I Just started. I experienced some remarkable positive effects immediately and want to check my blood work in Sept.  to see what shows up. Do not wish to have the blood work confounded with any other input from the time of the last bloodwork.

At this time I will respond to your lifespan  goal. From my perspective, it is not lifespan, but healthspan  we are seeking. This is a multifactoral  undertaking and necessitates efforts on several fronts. Your repeated  emphasis on the glucose/insulin ratio  as most the most important value has a lot of weight but is overly  simplistic.  I could never meet the 1.2 value you recommend.

I eat a lot of berries and fruit for their various polyphenol content-lot of sugar. I also have a cup of  homemade yogurt and keifer every day for their probiotic content. The fermentation process in each case converts about 1/3 the lactose to lactic acid but I still have a lot of "milk sugar".

Not discussed so far in these healthspan comments are benefits of hormone modulation therapy- Check out the multple antiaging benefits of DHEA supplementation if needed- see LEF's  "Disease Treatment and Protocol". This book also addresses male and female HRT. Unfortunately, it is somewhat out of date as recent publications on testosterone treatment to prevent dementia, osteoporosis and sarcopenia in seniors are not included.

These are just a few of the factors associated with ageing and means to slow it down. One of these is fish oil and I will comment on this in my comment to BOBm

Peter H. Howe Thats interesting. Did the doctor figure out the reason for your anemia? That is very strange for a man to have anemia. The body does not really have any efficient way of getting rid of iron in a man so it generally increase over a lifetime unless you are a vegan or have a slow bleed like an ulcer.

Fred Cloud Fred, I think it is in the genes. My brother, who is 7 years younger than I am, is also hypogonadic and had a stent inserted. He also supplements with a testosterone gel-- not with a patch delivery as I do.  Stents were not around 26 years ago. 

My suggestion to any mid age male who is anaemic and has high blood cholesterol , that they check their testosterone. Finally, this issue has been around for many years and was addressed by LEF contributors when I first joined. 

Peter H. Howe Genes for being anemic? Is your brother anemic also or just low test?

Fred Cloud Fred do not know will ask. As indicated this was a topic when I first started at LEF. At time I was full fledged beef eater  due to my wife's families occupation.

Peter H. Howe  So interesting. Generally you consume iron, and levels build unless you bleed. Your body tries to sock it away in long term storage as ferritin but that is toxic and causes aging too. Could be some genetic issue but I have never heard of it. Did your doc seemed concerned or checked you for ulcers. Do you take daily childrens aspirin or anything?

Peter H. Howe  Peter, You just do not understand basic science. It doesn't matter that YOU feel that tracking LDL-C is beneficial. SCIENCE says it is not. It does not matter what your LDL-C level is. If you have high LDL-P, you are a walking heart attacks. BTW, What was your LDL-P when you last checked it?

Fred Cloud .Checked quickly on google. There is a genetic component to anemia and transcription factor protein was identified.

I have never had an ulcer or blood in my stool. Had several colonoscopies over  the  years--not since I turned 75--too dangerous. Just stopped daily LD aspirin. The anemia was always with me before my bypass and aspirin.

LEF's book has several references to testosterone treatment resolving anemia issues.  Also  higher levels of testosterone decrease chance of heart attack and increases life expectancy in men.

https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400011

Above article documents treatment with chlomiphene increases testosterone and lowers cholesterol in hypogonadal men. This is a fertility drug used to stimulate  pituitary to produce FSH to stimulate ovulation in females. It is just beginning to gain  acceptance as means of increasing  testosterone in males  

Randy B Sorry, Randy,Ii have not checked in 20+ years. Do not need to. I have full grasp of basic science:  Fish oil and statin with lipid monitoring every 6 months. It has worked for 20 plus years and Insilco's models suggests I may have another 20.

I do not have to repeat VAP and LDL-P  unless a serious problem erupts.

Randy B + Randy (and Paul B as well ),  we have been through this before. For the last time, please follow my logic. I had an emergency bypass 26 years ago. This was based on an angiogram the previous day. I have not had another, and I am still here as you give me a hard time. Something is working. The probability of me going longer than 26 years after a bypass without another surgery or just being alive is less than 5 % . 

I explained before that a Dr Davis over 20 years ago sat down with me and integrated a statin and fish oil to prevent future problems. This was based in part on LDL-P tests and how it was affected by fish oil.  I agree that  that if you are starting from scratch , an LDL-P test is better than just LDL-C. I suggested a VAP test (Includes LDL-P) to BobM as one of the first steps he should undertake to evaluate his progress.

I currently include the Triglycerides/HDL ratio as one of the best indicators of how I am doing. A value of one says that that is where I need to be. If you have  long term trend of ~1 the possibility of an  ischemic cardiaic event is zero.  The Total C/HDL ratio also has value. I am not going to take a chance and I get both from a simple lipid profile.The LDL-C plays a role in how I proceed along with the ratios.

Finally, I use the ratios and lipid panel with some emphasis on LDL-C to evaluate experimental conditions that I am pursuing. If the ratio is much higher than 1 and LDL-C is high,  for one or two consecutive times-- the experiment stops. An example follows.

Attached you will find a summary of my blood work since April, 2016 which I will use to illustrate my approach.  I became a vegetarian in mid 2015, and wanted to evaluate whether or not I needed my statin as my Total C was somewhat low ( ~140) for a number of years.  I stopped my lipitor in early 2016 and there was almost an immediate unacceptable increase in all elements of the lipid panel ( especially LDL-C)  and my ratios. Needless to say I resumed my lipitor and everything returned to normal. Conclusion: I need my lipitor even under the best of diets. I do not need the LDL-P to make this decision. 

It is not simply a cost considertion. This plays a role, but I spend ~$700 for lab work per year with LEF - maybe more. I get everything I need--for now--  with this effort.

A second example is for my intermittent fasting  results that stared in 2019.  I will leave my comments on this for Fred Cloud as it has bearing on previous comments on testosterone, cholesterol and anemia we have had. 

Peace-- hope this helps.

Peter H. Howe May be of interest. https://www.doctorsbeyondmedicine.com/listing/people-with-high-cholesterol-live-the-longest

Paul Beauchemin Thanks Paul. I am aware of the studies referenced in the review article.  I do not agree with the conclusions in my case and the conclusions are dangerous to many like me that are genetically prone to heart disease.  I have been on a statin plus fish oil for almost 25 years after a emergency bypass over 26 years ago.  As I have indicated to BobM, it is the interaction of both taken together that prevents heart attacks in those of us who are genetically  prone to heart attacks-- the number one cause of mortality in U.S, at about 600,000/year. Without the statin plus fish oil, I would have been having this discussion with multiple relatives who passed in 40' 50'sand 60s due to cardiac arrest and who who did not have a statin.  

I went on a vegetarian diet and fish oil without a statin for two years  and my cholesterol went into the danger range. This effort on my part was due to studies that indicate if you drop below 160 Total C, mortality rates increase due to factors other than the cardiac issue.

We previously had the discussion on the relevance of Triglyceride/HDL ratio to predicting a heart attack. Mine is one due to the statin plus fish oil which indicates that my chance of a cardiac event is non existent. We can go one step further and conclude that the fish oil changed my LDL to the fluffy type based on LDL-P test. I provided BobM references to both of these. 

In terms of genetics, one predictor of cardiac events is your IGF-1. Below 80 ng/ml cardiac events increase. Above 150 ng/ml  cancer rates increase.  Mine is typically about 70. This can be a topic for another day.

For any of us to make it o a healthy 100, there are multiple factors for each of us to overcome, and they will not be the same for all of us. The exception may be the multiple benefits of fish oil. In this regard, I see that LEF has a fish oil article in the August , 2020 magazine.

BobM https://selfhacked.com/blog/homa-ir/

Randy B He also made significant improvements to his insulin resistance if you listen carefully. IMO that is the most important factor in the change

Paul Beauchemin  Dr Ford Brewer deleted your comment and called you out??

Fred Cloud yep

Paul Beauchemin Bob, could not disagree with you more.  On berries and fruits,  I reference you to Barry Sears books  "Mediterranean Zone and Resolution Zone" and  the need for polyphenols. Only way to get the amount you need is with berries and fruits, unless you drink~10 cups of coffee.  Also, multiple studies from Rush University and others document benefits of  including berries/nuts etc in diet. I tried a vegetarian diet with fruits and berries--not a lot-- and without my statin and and fish oil I would be on the other side getting reprogrammed for a new life. My HOMA score is 1.44. My TR/HDL ratio is one when I am not experimenting, and as you agree, this is one of best evaluators for health.

I also insist on my fermented milk products for the benefits to the microbiome (really big deal right now).  I prefer these to fermented vegetables  because of the protein content. I try to get 70-80 grams of protein per day (1 gram/kg) as suggested for seniors to prevent sarcopenia. I am primarily Norwegian and am not lactose intolerant. I also eat two slightly green bananas/day  for the prebiotics.

We are all different-- there is no universal diet that  applies  to all of us for maximum life extension. If you were to compare median life expectancy on your diet to those on the SAD diet, those on your diet would live  of 10 - 15 years longer. However, a significant number of individuals on your diet would die prematurely, while a significant number of those on the  SAD diet would out live the average person on your diet.  In an earlier E-Mail, I referenced my father-in-law who lived to 97 and ate meat and potatoes 3X per day. His wife died from melanoma at 62.  She would probably have survived today with the new cancer treatments ( See Jimmy Carter).

My father-in-law broke his hip at 93 and spent the last three years of his life in a bed in a nursing home. Was there a testosterone deficiency that resulted in osteoporosis?

I was personally  enthralled with the possible health benefits of the 5:2  and 16-8 diets. I was on these for the past 2 and 1/2 years.  An analyses of my blood work attached to yesterdays E-Mail to Randy indicated the diet increased my cholesterol, reduced my testosterone by 50 % and  increased my WBC.  Surprisingly, my anemia disappeared in contravention of all that I know about testosterone and anemia in senior men. However, I stopped the diets and returned to a 12:12 diet period.

As I suggested to you in a previous E-Mail, maximum life extension in my opinion is a multifactoral undertaking. It requires vigilance on a number of fronts. I have not seen, for example,  any discussion about hormones, pro and con. I am the only one who has brought up fish oil despite the LEF's long standing incorporation of this supplement in it recommendations along with several thousand peer reviewed papers.  

I am now excited about fisetin and started the Mayo protocol after someone on this site brought my attention to the risk assessment in Forever Health.

Paul, If you it his far,thanks for the effort. Had to get it off my chest.

BobM Bob I am prediabetic.  Offer the following to get most of everything you need  to start the day and it is delicious:

It is a smoothie with following ingredients and amounts. Unless noted I buy everything at Costco.

In blender blend  

1 cup (225 grams) low fat yogurt  ( mine is home made)

1 cup (140 grams) Wymans Frozen WILD blueberries (  yields ~1.2 grams of polyphenols if truly wild  and about twice the amount in farm grown)

 28 grams frozen almonds

40 grams Gold Standard whey protein isolate

10 grams Hersey sugar free cocoa ( yields ~ 300 mg polyphenols, cannot buy this at Costco)

Note that the protein in the whey will blunt the sugar spike from the unfermented lactose in the yogurt and sugars in the blueberries. You get your  probiotics in the yogurt. The blueberries and cocoa give you the anthocyadins needed for neurogenesis to go along with the fish oil you are taking.  Check you blood sugars after you try and let us know . 

Whey protein will boost your immune system. It is food of choice for those with HIV. You can verify with google search, and Life Extension has written several articles on its benefits. These include lactoferrin, immunoglobulins and cysteine to increase glutathione.

I see you belong to Consumer Labs and you can note that almost all cocoas exceed the California food  safety standards for cadmium. If you keep your consumption to 10 grams per day you will not exceed European weekly amount considered safe. 

A note of caution if you are taking metformin. In my case and supported by the literature, if you check, metformin ( as well as calorie restriction) will reduce your testosterone. Suggest you have your blood checked.  

Good luck and wish you the best..

BobM Forgot to ask. Are you taking fisetin? Saw your name on the section on this topic. I started in June and found it to be unbelievable in terms of improving my color vision and strength. Will do blood work in early Sept. 

@Peter H. Howe  Peter, I am very curious about how people use fisetin. And nice to hear that fisetin works well for you. Can you share how you use fisetint? Intermittently as  a senolytic and/or continuously as geroprotector?

Staffan Olsson Steffan, I became aware of the benefits of fisetin by following the fisetin thread on this forum. A key input was information and risk assessment  on the "Forever Healthy" website that come to my attention from one of you. Thanks.

I will be 80 in Oct and am hoping for some senescent cell removal benefits as studies indicate that it will remove 4 of the 6 different cell types. Do you know of any analytical method to document senescent cell removal ?

The literature also indicates that it will reduce cholesterol, increase insulin sensitivity and has other benefits, so I am also looking at it as a geroprotector.  

 In terms of my treatment protocol, I started in early June of this year and take 1.5 grams of the Swanson's product on two consecutive days twice per month, except in July when I only did one.  Basically I doubled up on the Mayo frequency with the amount equal to Mayo  20 mg/kg body weight daily dosage.  I take it on an empty stomach and do not eat for 3-4 hours afterward.

I will do an extensive blood work up at Lab Corp through LEF in early Sept. I did extensive blood analyses in mid May through LEF.  Will report the results. 

 As I reported previously, immediately after my first treatment colors (not my vision acuity) became very enhanced/vivid.  My strength increased significantly. I increased my chinups from ~ 20 to 26 and increased my pullups from ~ 22 to 28. The increase in strength and more vivid colors  continues. This has to be due to more than senescent cell removal as the benefits were almost instantaneous. Others on this forum have also reported similar benefits.

I suspect that fisetin my be the "real deal".

Staffan Olsson Staffan, forgot to mention in previous response that literature indicates fisetin is also mTOR 1 inhibitor and activates AMPK. Please include these benefits in its value as geroprotector.

BobM Thanks.

Peter H. Howe Peter.

I am happy you find Fisetin useful. I do to. some seem to have the idea that you can benefit from fisetin in different ways.

One way is to use the procedures that most of us seem to follow - to take fisetin intermittently and in very high doses for 2-3 days. This with the goal to eliminate as many senescent cells as possible. I do so.

The other way would be to, besides the above protocoll,  include fisetin in small doses every day. Like 200 - 300 mg per day. This with the goal to protect out bodies from processes that slowly destruct the brain and from other degenerative processes. Processes that are not (only) related to the removal of senescent cells.

I am not doing the above kind of intervention myself. At least not yet. Unfortuantely I lost the reference to the research that indicated that fisetin could have other positive effects besides the removal of senescent cells. If I find it I post it here in the forum.

@Staffan Olss See attached. First is the Forever Healthy website which includes a Risk Assessment  for fisetin with multiple sections focused primarily on senescent cells and Mayo Trials. You may have this. You have to scoll down to get to it. 

The second is from a world molecules website and has some details on other benefits. This includes a section on mTOR inhibition which I found extremely interesting. 

https://www.forever-healthy.org/home.htmlon 

https://www.worldofmolecules.com/anti-aging-and-senolytics/fisetin-molecule.html

Note that both websites have numerous articles, summaries and  risk assessments on other "antiaging" compounds we frequently encounter.

On AMPK stimulation and other benefits I mentioned you can google. Most are focused on rats and other organisms. 

I am very excited by fisetin. 

Hope this helps

Peter H. Howe  Thank you for the reference to World of molecules. it indicate that fisetin might useful in more ways than acting as a senolytic compound.

BobM 

Thank you very much BobM. Of course don't have a prescription so I hope it'll work I hope that I can get ahold of some from dropshipMD.

Regards 

BobAlgie 613-829-2722 on WhatsApp

BobM  Hi bob, If you wouldn't mind can you tell me (us) what you paid for your Rapa and Dasatinib? I'm always looking to stock up on my supplies.

BobM Thanks

BobM Oh, you were able to purchase from theantiaging store in march? They been out of stock on both rapa and dasa for a while. I keep rechecking but such luck yet.