Metformin

Thought I would share a recent article that I saw regarding Metformin -very interesting points being made.  I just starting taking it as part of my overall anti aging approach -  I am Type 2)  but was alarmed regarding the potential impact with respect to doubling the risk of Alzheimer’s and Parkinson’s.  

https://bengreenfieldfitness.com/article/supplements-articles/dark-side-metformin/

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  • Inevitably when a new approach becomes popular there are people who like to shoot holes in it, weaving an argument against the approach. News is made by narratives, both pro and con, and the more convincing the narrative sounds the more clicks it'll get. Digging a little deeper

    "“Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes,” when combined with sulphonylurea (another common antidiabetic medication), metformin can actually result in an increased risk of cardiovascular complications and all-cause mortality."

    Few here are also taking sulphonlurea I think. 

    Anyhow Metformin has a long history with millions of people taking it, many studies showing the aging benefit as a side effect, and we also know the reason why it has a aging reversal effect. Knowing the what and how, to a high degree of certainty is my standard. Also considering that there are almost always negatives. Simple examples - a knife can help you make food but can hurt you, same with fire, a car gets you places but is a dangerous form of transportation, etc. But of course if you don't feel an approach is good for you then listen to that. I've personally always been against pharmaceuticals, but the evidence for the value to addressing aging is now too strong IMO. 

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  • Recent review article on metformin.

    Metformin and Aging: A Review

    https://www.karger.com/Article/Pdf/502257

    Questionable efficacy if one is very healthy, low glucose...especially if high exerciser. Surprised the TAME trial has not yet started.

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  • New research shows metformin turns on unexpected kinases and pathways, many independent of AMPK. Two of the activated kinases are called Protein Kinase D and MAPKAPK2. These kinases are poorly understood, but are known to have some relation to cellular stress, which could connect them to the health-span- and life-span-extending effects observed in other studies.

    https://www.sciencedaily.com/releases/2019/12/191204090815.htm

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