Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
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Guys, anyway knows a way to easily distinguish what is fisetin and what is not?
I've ordered some with a Chinese supplier. One was obviously a scam, with some curcuma taste.
Now I've got the other. It is fine yellow powder with a bit greenish hue, from cotinus. With CoA of 99%. Well, this one IS the most bitter tasting thing I've ever tested on my tongue! It is quite stainy, and smells musty.
But what puzzles me, is that Doctor's Best is not bitter at all.
Do you have any experience/ideas of how to figure this out?
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JGC I agree it is the only viable way to check. On the other hand, I've found this description of it's properties. It is saying, that it is in fact bitter:
https://foodb.ca/compounds/FDB000624
So maybe if it is really 99%, it is a strong concentrate showing those properties?
I will first try 400-500mg. A bit afraid to start with anything more. But the big advantage of Chinese suppliers is the price. It was around 25 dollars with shipping for 50 grams (52.7 with a plastic bag, I've checked it).
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Andrew Whitfield Fisetin is NOT bitter. It is VERY similar yo taste and appearance to the more popular and more widely available Quercetin ( differing by only a single -OH group) - light yellow powder with very slight "powdery" taste. Bitterness may point to low purity and/or presence of solvents.
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Andrew Whitfield If I have to guess, bitter yellow powder points to Berberine.
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aribadabar Why is it written then on a chemistry website that it is bitter?
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aribadabar Well, in fact, if you google quercetin taste, it is stated everywhere it is bitter https://en.m.wikipedia.org/wiki/Quercetin#:~:text=Quercetin%20has%20a%20bitter%20flavor,supplements%2C%20beverages%2C%20and%20foods.
Although I did not ever try it
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Andrew Whitfield You have a known good sample from Doctor's Best which you stated yourself is not bitter at all. If you still have any doubts about my statements, I suggest you buy from another reputable source and compare....
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aribadabar Can you suggest any good source for a bulk powder?
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Andrew Whitfield I have tried both Quercetin and Fisetin from 3 different sources - they ALL tasted very similarly and none were bitter at all. I also tried Berberine which was vile bitter yellow powder similar to the description you made above. Make what you will from this...
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aribadabar Can you suggest any good source for bulk fisetin? I am not arguing with you, just exchanging info and opinions. While if you could advise a good source, it would be greatly appreciated
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Andrew Whitfield I only used this bulk source: https://www.ebay.com/itm/293083396786
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aribadabar I know it. But I am not from US, so not an option.. :( Will have to think about possible alternatives.
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Andrew Whitfield As to why it is written as bitter in a chemical datasheet, perhaps in chemistry speak bitter means anything "not sweet" ?
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aribadabar Maybe yes. By the way, I've did the simplest tests I've could at home. Checked the water solubility - it is very low, powder is just going to the bottom. So most likely not berberine, which is water soluble. Tried the UV - there is some glow (it was written somewhere it should glow), and compared the color visually to the ebay source which you provided. The color seems identical. Well, it would be so curious to put it under spectrography, but I suspect it would cost more than my whole package.
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aribadabar The seller has replied me it could be a difference in the extraction process and bitter taste may not be removed with activated carbon. But it was a google translate from Chinese
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Andrew Whitfield So crappy extraction i.e. high level of residual solvents it is. Your call but I would not consume it as it markedly deviates from a known good sample.
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aribadabar Is there any simple way to purify? I am also cautious about it. Not willing to poison myself. Of course the seller claims it is safe and provides CoA from the Lab. But who knows. Anyway, thanks for a meaningful and knowleadgeable discussion. I've found a US-based source who ships 500mg pills to my country, will try them.
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aribadabar To give you some context: with doctor's best, what I am generally unhappy about is consuming a huge amount of waste/fillers. That's why my quest for bulk has started..
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aribadabar That's interesting. Hmm. So, doctor's best vs this bulk. Visible vs UV.
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Andrew Whitfield Don't know which one is Doctor's Best but the upper, slightly lighter, non-glowing under UV one, seems like the Fisetin I have come across.
The bottom one is too yellow and resembles Berberine more.
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aribadabar Doctor's best is the dark one
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Andrew Whitfield Fairly certain you have received Berberine then. Saturated yellow, VERY bitter powder - checks out.
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aribadabar Maybe.. I am confused though, as some guy on fightaging website was claiming fisetin should glow yellow-greenish under a fluorescent light. And doctor's best is black. Maybe fillers also react to the light. Anyway, waiting for my 500mg pills from some other US supplier, let's hope this product won't be so questionable
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Follow up: consumed 500mg with a buttermilk. No ill effects, all is fine and bitterness is bearable.
At first got a bit of a psychosomatic stuff like cold hands, fearing to get poisoned :D But all went fine, so I will try gradual 1g and 1.5g.
aribadabar
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aribadabar Noticed it also being quite stainy, like painting my cup yellow. I've had similar thing previously with other fisetin, so maybe it is still what it should be :) But maybe not perfectly clean extraction.
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