Fisetin experimentation one year (reposted as topic for info purposes)

Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways. 

 

To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).  

 

My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations. 

 

So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often. 

 

i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years. 

 

So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely. 

 

As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.

 

I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive. 

 

I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes. 

 

Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon. 

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  • I read that quercetin is also a good anti viral.  Lots of studies done for SARS.   Dr. Mercola had a good page on it. 

    Like 2
      • David C
      • David_C
      • 1 yr ago
      • 3
      • Reported - view

      Robert Olin  yea quercetin is popular but usually in combination with something else. Fisetin was almost as effective as FOX04 DRI by itself which is why I went for it. You can buy it easily. 
       

      I imagine all of it works to an extent. But better more tailored treatments are on the way. So for me I am using what works now and is easy to get, not to mention that it’s safe.

       

      when the new stuff comes out I am going to try and be an early adopter.

      Like 3
    • Robert Olin Yes, Quercetin has shown good effects on ebola virus, Zika Virus, and birdflue-SARS. But so far only been tested on animals. Now there is a human study on its way in China. I think it is done in cooperation with Universty of Montreal, where the lead resaecchers are located.

      Like 1
  • My wife and I have done two fisetin runs with no noticeable effects. D&Q next.

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  • Let me know how it goes. Like I said before, for senescent cell clearance you really have to be patient. It would likely take 6 months or more to have an appreciable effect. Theoretically when you eliminate bad cells like that you are also removing the signalling that interferes with normal tissue maintenance.

     

    I imagine in the absence of SASP it still takes the body a while to regenerate cells and reorganize tissue back to a more healthy state. It's not something you will notice overnight.

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  • Hi all,

    I would like to circle back on the note about NOT taking antioxidants with the senolytic treatments.

    So many questions about this!

    Like -

    Stopping how long before?

    Which ones are the most problematic?

    When can I resume?

    How/why is this a problem?

    What other supplements might be affected the same way?

    In general, should we by cycling all our supplements? Like take this group together for a week, then the other group?

    Thanks for all your thoughts!

    bob

    Like 1
  • Well in general I would cycle everything. Take a break, re-evaluate and continue if everything seems ok. I took a week off my NMN supplementation and am about to start again.

     

    In regards to fisetin I imagine it's not as serious a senylotic as some of the other compounds so I'd be surprised if there were any issues with it. What antioxidants are you referring to and what is the interaction we should be trying to avoid with it?

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  • David C Regarding Testosterone boost. I ran across this study showing senolytic treatment reverses age related testosterone decline by killing off sensecent cells in the teste leydig cells. 

     

    FOXO4-DRI(senolytics) alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
    https://www.ncbi.nlm.nih.gov/pubmed/31959736

     

    If this is true, it is huge news as men could start treating their andropause with senolytics rather than testosterone replacement.

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  • Yes I saw this, I commented in another thread about it. This might be true. Ever since taking fisetin the first time I am much more in the zone so to speak . I’d almost call it aggressive, but really it’s more confident. Definitely made women a lot more interesting. I cal also put on muscle fairly fast.

     

    id swear there is something to this. And the effect lasts months after dosing. So I was just thinking I was imagining it a bit. But honestly it’s fairly profound.

    Like 1
    • David C Have you done before and after testosterone blood levels to see how much it is boosting your T levels?

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    • David C 

      Last weekend I did a 3 day senolytic treatment and combined it with physical exercise.

       

      My protocol started with piperlongumine extract with black pepper and then after 30 minutes I had 30 mg fisetin per kg bodyweight. (I mixed the fisetin the same way as they did in the mayo study) After 3 hours I had triple dose of senolytic activator and then Curcumin.

      The first day my exercise was 10 hours after the fisetin. I was running quite slowly for 30 minutes. I got a little bit of sore muscles from this (which I otherwise never get from slow running).

       

      The third day I used almost the same protocol as the first day but I mixed the fisetin differently. I took the fisetin capsules in my mouth and chewed them with olive oil+ avocado oil until it became a soft dough. Then I swallowed the fisetin.  On the third day I increased the exercise intensity to maximum. Running 10+10+10 minutes at max speed. Then 90 seconds maximum speed running up a steep hill. And then a couple of maximum short sprints (15 seconds) After my sprints I got cramps in my quadriceps for the first time in my life. And a got incredible sore quadriceps. The soreness lasted till today (for Three days).

       

      I have previously had an experience of fatigue when doing this kind of protocol. Then I have been weak for a few days after the protocol.

       

      But I have also experienced what previously have been expressed in this thread, That my legs have had more strength and I have had a light and energetic mental state, almost feeling a bit euphoric.  but that have been 3-4 days after the treatment. I feel it coming today. Three days after the treatment.

       

      I have gotten that kind of uplifting experince when taking fisetin alone as well as in some combinations. It also increased libido. And I have gotten a similar positive and almost euphoric feeling (but not increased libido) when I start my day with Green tea extract and quercetin followed by curcumin 1-2 hours later. My guess is that some substance or some metabolites cross the blood brain barrier and creates a great feeling of wellbeing.

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      • David C
      • David_C
      • 1 yr ago
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      Staffan Olsson so this is exactly what I experience when exercising with fisetin or generally feel. Immediately following dosing I get sore easily. Not terribly so, but it’s noticeable. Muscles build and become more firm faster. And after a few days or so the muscle fatigue and inclination to get sore goes away.

       

      Then it’s just easier to workout and I have a more firm and strong muscle capacity. For me the effects have become almost permanent as I do it monthly. I also notice a more relaxed feeling in soft tissues as if there was an anti inflammatory effect.

       

      Its nice to have some collaboration on some of this. 

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      • David C
      • David_C
      • 1 yr ago
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      Fred Cloud nope I have not. I suppose someone should. I am not certain that’s what happening but it would explain a lot.

      Like 1
  • It reminds me of fasting and exercising to induce autophagy. Do you think exercise is increasing the susceptibility of senescent cells in muscles to die?

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      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Fred Cloud It's so hard to know. I can tell you this the muscle fatigue and soreness feels good in a way, kind of like after you have a nice workout and the day after you can feel the effects.

       

      The first time I dosed with Fisetin I felt a weird fatigue. It was not unpleasant at all. I remember because I wanted to take a walk the morning after, was excited to do so. And I walked out a bit and my legs were tired and felt a little sore so I was like Jesus man let me get home.

       

      The following day, the fatigue was a little there but I noticed a lot of strength in my legs. I had a weird computer desk which was a pain to get out of, and I just glided out of it effortlessly, and I was like wow this is new. Also my legs were very firm, buttocks too. From doing virtually nothing. When I sat down I felt like I was firmly sitting there with very firm buttons and legs.

       

      It felt like the legs were actually rebuilding and becoming firmer. And a lot of this was throughout my whole body. Chest, arms everything, much much more firm. Just in a few days. I would push on my stomach and chest muscles kinda making sure I was not imagining all of it. 

       

      All in all this is my account of things. It's not statistics, but I can tell you I was skeptical when trying Fisetin, I really did not expect any kind of effect. I figured if it cleared senescent cells that this would hardly be noticeable by me, and likely play out over the long term. So I was not in the mindset to get a "placebo" effect. I had no expectations.

       

      It's definitely something that should get more study time. I really like Fisetin because it's cheap, has a senoyltic effect, and seems to beneficial for overall health. But who knows, the most I can say is give it a try for yourself. The science behind it will catch up sooner or later and maybe we can better understand what it is and is not doing. 

      Like
  • I had endoscopic back surgery a little over a year ago.   They used a tiny dremmel thru a tube to router out some of the bone that was pressing on a nerve, all due to an aging disc that isn't as fat and plump as it was years ago.  In fact I'm about 1.5 inches shorter than I was in my early 20's.   The surgery eliminated the sharp pain but my back now is aching all the time, so my use of fisetin  is in hope of rejuvenating  my aching back.   Hope springs eternal.   I've just added BPC 157 so I'll keep you informed.

    Like 1
  • Hello, I am 42 and taking perindopril (acei) and bisoprolol (beta blocker). Did anyone had experience of taking fisetin with this class of meds? Any hazards/issues?

    Like
    • Andrew Whitfield 
      Fisetin is in fruits. 
      However, it is most commonly found in these superfoods:

      • Strawberries.
      • Mangoes.
      • Cucumber with skin.
      • Apples.
      • Persimmons.
      • Kiwi.
      • Peaches.
      • Grapes.
      Like
    • Andrew P K Yap I know, thanks, but how is it directly related to my question?

      Like
    • Andrew Whitfield It should be safe. Just watch out for upset stomach. From what I know these stuff from edible plants, that is as bad as it gets, needing to go to the toilet more than usual. Furthermore, once your body gets used to it, even this harmless problem goes away.

      Like
    • Andrew P K Yap Rapamycin, I saw a David Sinclair interview where he said he wouldn't take it.

      Like
    • Andrew Whitfield  Another thing, take it intermittently, don't take it continuously. Just common sense.

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    • Andrew P K Yap Thanks for your advice! I am willing to try it were cautiously, like take 100mg on the first day, see if any bad effects. If none, try 400 the next day, again, and then if all is fine take 1.5-2g for 3-5 days. I will report here on the result, it could benefit others also.

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    • Andrew P K Yap Was it intended for me? I don't know about rapamycin specifically.

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    • Andrew Whitfield I was contrasting between Fisetin, which is found in "edible plants" and Rapamycin which is a drug prescribed for organ transplant patients. Some people use Rapamycin to "cure" aging . 

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    • Andrew P K Yap  Yes. But let us not forget how different mg/kg is with plants and pills. Unless we eat 20kg of strawberry...

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    • Andrew Whitfield https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/

      I have not read anything about it being toxic and instead read about how safe it is.

      Like I said previously, the first thing you notice if you overdose, is upset stomach.

      Your plan which you mentioned previously seems very prudent.

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      • Joe smith
      • Joe_smith
      • 1 yr ago
      • Reported - view

      Andrew Whitfield potentially not safe due to interaction with the meds you already taking. Please see the following article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703353/

      Like
      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Andrew Whitfield if you can tolerate it, I take 3g for 3 days and that works for me. Best results are on empty stomach and don’t eat for 4 hours after. 

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  • I would be careful, if it were me I would try. But to be 100% safe don't do it. I think it might improve some of the underlying health issues possibly. However none of us are doctors.

    Like
    • David C 

      So I have done two experiments.

      Tried doctor's best 100mg in the evening. Felt pretty much good, a boost in energy and was hard to get asleep. The next day was very energetic and felt well. No side fx on my medication.

      Yesterday I have tried some unknown origin fisetin from ebay, which is 2:1, 450mg rhus extract. I am no expert, but the pill is 225mg. Not sure about the fisetin content in it. Felt something similar, and a minimal upset stomach.

       

      Will be moving towards proposed megadose. As you can ser for now all is fine.

      Like
      • David C
      • David_C
      • 1 yr ago
      • 1
      • Reported - view

      Andrew Whitfield Awesome let us know if it works. It's a weird thing. What I was expecting and looking for is a senolytic effect that I expected would unfold over a year or more and be hard to really quantify but I get immediate effects from it.

       

      So I never really can understand why that is. I have gone from thinking it stimulates testosterone production somehow or that maybe in addition to getting rid of senescent cells it suppresses SASP secretions and allows for an immediate stop to low grade age related inflammation.

       

      Look for muscle strength, firmness, and also check your face for more definition and a relaxing and reduction of puffiness in the face. Also mood, mental clarity, audio clarity, and increased drive and energy.

       

      When I take it I notice the that after three day superdose I am a little wired for a day or so and then it relaxes. The effects last for at least 3 weeks solid and then normalize during week four. Which is why I do it monthly. But I think you could safely do it every 3 weeks (I have recenlty). 

       

      I'll be honest I was worried about too much testosterone and hair loss...since I could not explain the effects (no doctor here) other than to say it must have stimulated testosterone production. If this is the case, how it does if for such a long period of time after dosing I dont know. Fisetin has a short half life, something like 4 or 5 hours if I remember.

      Like 1
  • I've taken 2 courses so far of 100 mg Dasatinib, 1000 mg Quercetin and 1500 mg Fisetin. Each course lasted 3 days. I felt nothing (other than the usual headache and runny nose). I think possibly that the more senescent cells you have the more of a rejuvenation effect you will feel when they are eliminated. No science to back that up, just my gut feeling.

    Like 1
  • Anyone have any info on a peptide called FOXO4-DRI that is supposed to suppress FOXO4 and increase senescent cell apoptosis?   Is it available?  

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    • Robert Olin  try Bucky Labs

      Like
    • Can someone explain to me what is FOXO4-DRI and if there are already people taking it?

      Like
    • Paul Beauchemin Thanks Paul.  I just ordered some.   Sounds at least as important as fisetin.    What do you know about it?

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    • Robert Olin Good morning, can you tell me why FOXO4 is important with the fisetin?

      Like
    • Paul Beauchemin Good morning, can you tell me why FOXO4 is important with the fisetin?

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    • Robert Olin You ordered some? Well that was fast, yesterday you didnt know much about the substance and now less than a day later you already ordered some. I am impressed with your level of risk tolerance ordering from some random supplier with no assurance of quality or safety and is labeled not for human consumption and you are ready to start injecting it? So what dose are you going to take?

      Like 1
    • Fred Cloud Do you drive down the street with a mask on?   Risk tolerance goes up when you are old and in pain.   But it's MY choice.   Not yours.    The Bill Gates of the world want to vaxx you and make Billions.   They have no incentive for you to live longer and muck up their world.    

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    • Robert Olin Of course it is your choice, did I tell you that you shouldn't use it? I only  see that I gave you a compliment for going for it. I usually take a few months of research before I feel comfortable taking something risky and people still criticize me for being careless, so I have always considered myself having high risk tolerance more so than most people. But I never attack them, especially if they give me a compliment for going for it.

      Like 1
      • aribadabar
      • aribadabar
      • 11 mths ago
      • Reported - view

      Fred Cloud As a neutral observer, I can say it does come across as backhanded , if it was indeed a compliment and more like a criticism

      Like
  • Guys, I have a largely theoretical topic/concern. Could there be any damage to healthy cells from the fisetin?

     

    Logically thinking, if it is an anti-proliferative agent, invoking apoptosis, could it non-selectively damage healthy cells also? Like the chemotherapy, which would also damage healthy cells.

     

    Another similar concern is about it being topoisomerase inhibitor, how bad could it really be for the body?

     

    And from the wikipedia, what do they mean by this?

     

    "Like the other compounds, it has also been shown to be reactive in many different assays of biological activities, raising the possibility that any drug generated from fisetin would have too many side effects to be useful.[12][14]"

    Like
    • Andrew Whitfield Other senolytics like foxo4-dri definitely do have collateral damage and kill off healthy cells, so your theory has merit. So for every 10 senescent cells foxo4-dri kills off it also kills off one healthy cell which is alot and is why one of the lead researchers said he felt foxo4-dri isn't safe. But fisetin seems to have more selectivity and so I think you are safe. Having said that I wouldn't take anymore than you need to. Some people take 2-3 grams per dose and have reported issue with healing and bleeding. Some of the more conservative doses scaled up from mouse studies say 500mg should be effective. If you take a round and can feel some of the effects of killing off senescent cells, alleviation of some chronic condition or even just post round hunger might be sufficient to dial in the dose to a minimum effective dose.

      Like
  • Unlike chemo drugs that directly target and kill cells, fisetin does not do that. What it does is that it induces cell death. In other words, it encourages the body to remove senescent cells. I hope that you can appreciate the difference.

    Like 1
    • Andrew P K Yap 

       

      Thanks. But how does it choose selectively? Is there a risk of harming healthy ones? I have read some descriptions of dropped WBC in blood test after it. Which sounds a bit alarming.

       

      And what about the other point I mentioned, like inhibition of topoisomerase?

      Like
      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Andrew Whitfield Well the truth is the mechanisms behind fisetin are not that well known. There are good theories but i have read different ones. The main thing to remember is that they fed mice huge doses and nothing bad happened but increased health and life span. 
       

      So most of this stuff is take at your own risk. However Fisetin seems fine to me. Over a year on it. Even FOX04 is targeting a specific pathway. There is no guarantee that somewhere somehow good cells are not being affected negatively. 
       

      Any senolytic you take in these early days carries some risk as we need decades of observation to truly understand how these things work in humans. The thing is do you have decades?

      Like
  • Andrew Whitfield Fisetin does not "choose selectively" to destroy senescent cells. So why does taking fisetin remove senescent cells? The simple answer is that your own  genes remove senescent cells. Fisetin "triggers", "induce", "causes" those genes to activate, when they receive chemical signals from fisetin.

    Your body will not get signals from senolytics and start destroying perfectly healthy cells.

    The danger is, fisetin is or at least might be toxic at very high levels. So, you look at the safe dosages and how long to take it, the recommended course of taking fisetin.

    Like 1
      • Jack Black
      • Jack_Black
      • 6 mths ago
      • 2
      • Reported - view

      Andrew P K Yap Fisetin (and Quercetin) inhibit the expression and activation of the PI3K/Akt/mTOR signaling pathway in some types of cells which enhances apoptosis. In some studies it was observed to suppress proliferation of tumor cells through this mechanism. Sheeky shared a rather nice diagram of different senolytic pathways this week;

      Like 2
  • Sorry for any grumpiness.    My backs been aching 24/7.  Had some endoscopic surgery 1.5 years ago and I'd like to avoid doing it again.   Yes taking FOXO4-DRI is a risk but so is rock climbing.   I do appreciate your feedback but like Dylan said "When you ain't got nothin you got nothin to lose."

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      • David C
      • David_C
      • 1 yr ago
      • 1
      • Reported - view

      Robert Olin There have been self experimenters who had no issues with it. The guy at buckylabs if I am not mistaken took it for a long time. 

      Like 1
    • Robert Olin No worries Robert, hope your back heals.  Just off the top of my head I would think that for back pain you would want a senolytic that targets fibroblasts like azithromycin but you may want to research it to confirm.

      Like
      • Jennifer Smith
      • We are all responsible for our own health, wealth, and happiness
      • Jennifer_Smith
      • 1 yr ago
      • Reported - view

      Robert Olin I hope you are feeling better. Any update?

      Like
  • Hello guys,

    So as I have mentioned earlier, I am on bisoprolol and perindopril for my hypertension.

    Ive just got a Swanson Fisetin 100mg pills, and have tried two dosings, 1 pill and 2 pills in two evenings before sleep. I did not notice any ill effects, and my heart is also fine (HR and BP on usual levels).

    I will follow an unusual (safer) approach doubling the dose until I reach 1200-1400. So today I will try to dissolve 4 capsules content in olive oil and take it in the evening.

     

    Will report more later on! :)

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  • I have tried putting the 4 capsules content into extra virgin olive oil. It was absolutely disgusting! A bitter taste, powder did not dissolve well.. Guys, how do you resolve it? Are you choking on 10-15 pills, ingest pure powder or use some other way. Please share some advice.

    Like
      • JGC
      • JGC
      • 1 yr ago
      • 1
      • Reported - view

      Andrew Whitfield 

      Last year I ordered 100 gm of >98% pure powdered Fisetin from VitaSpace for $190 plus $6 shipping.   I put Trader Joe's Extra Virgin Olive Oil in a shot glass, heat it the microwave for 40-60 seconds until its quite warm but drinkable, put the shot glass on a milligram-sensitive digital scale that is tared to zero, add 2 grams of the Fisetin powder, stir vigorously until I get a mustard-colored liquid suspension (and possibly partial dissolution) of the Fisetin powder, and then gulp it down with a toss.  Then I scoop out the residue with bread fragments and eat those.  The taste isn't great, but I wouldn't say it's disgusting.

      Like 1
    • JGC John, How often do you do a round of senolytics?

      Like 1
    • Andrew Whitfield try buying a mini blender.  I bought a tribest off amazon.  2-3 cups small. I blend all my pills to get them down.

      Like
      • garland
      • garland
      • 1 yr ago
      • Reported - view

      Andrew Whitfield I am not sure what brand of Fisetin you are using... most of the ones I use blend in well with olive oil.... true a bit grainy but not the end of the world. I use Swanson brand or Doctors Best...it i very thick and heavy I polish it down with water with each spoonful.

      Like
      • Jennifer Smith
      • We are all responsible for our own health, wealth, and happiness
      • Jennifer_Smith
      • 1 yr ago
      • Reported - view

      Andrew Whitfield I am late to the discussion but I wonder why you are trying to dissolve the capsules in oil before taking them. I see you are not the only one doing so.

      Like
    • Jennifer Smith It is never too late :) Actually, I am using powder from China, 99%. Not pills. This is much cheaper, but, if course, you don't know what exactly you get there.

      Like
  • I straight up take 30 pills one by one. I do this three days in a row. I found that i should wait 24 days between dosing. 

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    • David C

      2 grams seems like a very sufficient dose.

      Do you find that 3 grams is noticeably better or different than 2 grams?

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      • Randy B
      • Randall_Bagrowski
      • 1 yr ago
      • Reported - view

      Fred Cloud  2 grams of Vitamin C is a pathetic dose. Consider that animals that make Vitamin C DO NOT get cardiovascular disease. Also consider the fact that most animals that make their own Vitamin C make about the human equivalent of 15 grams per day.

      So an adequate dose would be about 12-16 grans/day divided into 4 doses throughout the day.

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      • David H
      • David_Hanson
      • 1 yr ago
      • 1
      • Reported - view

      Randy B I think that Fred Cloud was writing about fisetin not vitamin C.  Are you saying that there is a relationship between fisetin dosing and Vitamin C dosing?

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      • Randy B
      • Randall_Bagrowski
      • 1 yr ago
      • Reported - view

      David H  I think you are right. Apologies for any confusion. As for C/Fisetin I do not know of any relationship between the two 

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      • David C
      • David_C
      • 1 yr ago
      • 1
      • Reported - view

      Fred Cloud well I prefer 3g as its not dangerous. I also weigh around 230. I get a very nice effect from it. I typically take it on an empty stomach before going to bed now. These translated doses from mice are lower for humans as they calculate for metabolism but i felt like 800mg more would not be harmful and what if their translated doses were not super relative for the senolytic effect.

      Like 1
  • Well, I've ordered some fisetin from ebay derived from cotinus coggygria, 98%. Used kitchen scales to measure, so I have put 0.8g to the yoghurt and used it.

     

    After ~1 hour I have felt a bit lightheaded, some minor tachycardia and a boost of energy like from caffeine. A little upset stomach, but very mildly.

    I will try 1g tomorrow, let's see how it goes further.

    Like 2
    •  So I did a 3-day course of 1.2g. Did not notice much of an effect, but no side effects either.

       

      Two months have passed, I am going to repeat now. I am again trying low dose first as my perindopril was changed to valsartan, so again careful on new medication combinations. I will report.

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  • Yeah 2g or even better 3g give the best results for me but take it easy because we are different

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  •  

    I got this and eat it on buttered toast. All good. Doing a high dose 2 days in a row. This was maybe $50 on ebay. Came with papers saying it was tested pure etc. 

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      • garland
      • garland
      • 1 yr ago
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      Jennifer Smith it is not the purity of the product it is the availablity of the product to get in the blood stream. I think that if you eat it with butter that that should help availability. But if you want to try a much higher available product try LE Bio Fisetin. There is research on that one. I have tried regular Fiseten maybe 12 or 15 times and the Bio Fisetin two times... i feel the Bio Fisetin seems more powerful....course i do large amounts of both products.... 10 a day / for 3 day of Bio Fiseten and 2200 mgs of Fiseten / for 3 days

      Like 1
      • garland
      • garland
      • 1 yr ago
      • 1
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      Jennifer Smith I do not know where you got this from but alway take overseas supplies with huge caution. there could easily be pollution from heavy metals.. Just because they are from India does not mean that they are high quaility. I had my losartan Blood pressure drug recalled because of pollution from Cancer causing agents. And many studies have found large amounts of heavy metals in foreign herbs from India and China... that to me is taking  a huge risk...to save a few pennies...

      Like 1
      • Jennifer Smith
      • We are all responsible for our own health, wealth, and happiness
      • Jennifer_Smith
      • 1 yr ago
      • Reported - view

      garland I also eat a pouch of dehydrated strawberries with it, just in case there are symbiotic compounds or something. I also hope that by chewing it up it will also help absorption. I am making this stuff up as I go so was happy to stumble onto this forum. I was actually researching a stock trade when that research led to this research. I have no education or history in either field. Isn't this fun!!!

      Like
  • I thank you for your reply first and foremost. I didn't buy it with price in mind but did go the big bag based on price. This came with paperwork saying it was tested and blah blah blah but I bought an RX at Walmart once that I think wasn't what it was supposed to be. The ad on eBay also talks about all the right stuff, agreeing with you on being careful of supplies. It seems to me to be a crapshoot on who to trust these days on anything but especially our own health. 

    https://www.ebay.com/itm/FISETIN-98-pure-powder-extract-no-fillers-cost-effective-ANTI-AGING-/293083396786

    if you would please have a look and tell me what you think. 

    Like
  • Hi Fisetin Fans, I just discovered this site and have read all 122 comments which are mostly from David C. Thank you David for sharing your results in detail. I have been following and posting on a similar thread which you might find interesting here:

    https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/#comment-35827

    Here is my experience so far. I am 71 so mostly interested in the longer, slower senolytic effects not the short term ones that David has shown. I used the Mayo Clinic protocol which resulted in 1.5 grams a day for 2 days (based on my 70kg weight). Repeat after one month and again after 6 months. I have tried breaking up the capsules and mixing with olive oil and just taking them with water. Results after one year have been disappointing. Like most people here and on the other forum I feel no positive changes in aging related health problems, of which I have few.

    I am concerned about the low bio-availablilty of Fisetin. I've read that the solubility in water is only 0.151 mg per ml. This works out to 571 mg per US gallon so you should be really drinking about 2 gallons of water per gram!!

    I know that LE has come out with bio-fisetin that contains a special fiber but they show no links to any science that proves this works although someone wrote here that it was proven. Please provide us a link on that. Also LE has a mix of 3 nutracetils that they call Senolytic Activator but there is no science on that either.

    I will continue to search for a senolytic that provides results for humans, not just mice but so far it doesn't seem to be matching up.

    Like 2
      • Fred Cloud
      • Fred_Cloud
      • 11 mths ago
      • 2
      • Reported - view

      Dean W. Thats shocking. I definitely feel an effect from taking fisetin as a senolytic. What brand were you using? There are other senolytics out there, you may have to try those instead. Have you tried other antiaging things like rapamycin etc ?

      Like 2
      • Van
      • Van
      • 11 mths ago
      • 1
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      Dean W. Dr. Green recommends 500 mg Vitamin C to help with bioavailability. Here is a post from Dr. B. concerning senolytics. There are only two studies that senolytics increase lifespan in any animals. In one of the two, Fisetin slightly, with minimal statistical significance, increased lifespan in a few mice see Fig. 5A. No further confirmation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/

      Like 1
      • Dean W.
      • Dean_W
      • 11 mths ago
      • 1
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      Fred Cloud Like most here I get my fisetin from Swansons in 100 mg capsules. Please list the positive effects you have noticed and your age. I suspect David C. is way too young to have many senolytic cells as  it takes at least 50 or so replications before a cell either dies (usually) or lingers in the senescent state (<1%).

      Like 1
      • Dean W.
      • Dean_W
      • 11 mths ago
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      Van That is why fisetin is disappointing I guess. It barely works in mice. I am going to look into the Dastinab/quercitin method. That is the route that showed so much promise in mice. BTW, I do take 500mg of C daily.

      Like 1
      • Fred Cloud
      • Fred_Cloud
      • 11 mths ago
      • 1
      • Reported - view

      Dean W.  Your cells can become senescent for reasons other than hitting the cell division limit.

      https://www.sciencedaily.com/releases/2020/09/200929123530.htm

      I have seen positive reports from younger people.  fairy8i8 on here has reported positive effects from senolytics in her 30s.

      Like 1
      • Van
      • Van
      • 11 mths ago
      • 1
      • Reported - view

      Dean W. Same with me.  I have taken Fistein, Dasatinib, and nothing to show for it.  Rapamycin, Metformin is best combination I have found.  Lost 25 lbs.  Losing weight is a big boost to health.  Tracking my blood test results is best way to see if anything is working.  If you have to same blood work up as when you were under 50, you are doing well. 

      Like 1
    • Dean W. Dean, I have also had significantly different results using the the Swanson product following the Mayo protocol.  I experienced an "immediate" increase in strength based on my regular exercise program ( not placebo). This was quantifiable.  I also "believe" that my color vision improved significantly, but this is an opinion as I did not have any benchmarks to compare as I did with my exercise program.   

      I did not see an change in my blood chemistry  and the  Levin phenotype age and  DNAm age from before use to after use.

      I do not know what caused the strength improvements and doubt that they were due to removal of senescent cells due to the immediate improvements in strength.

      Note that as you indicated several others have reported similar changes. Mine may be due to my age -- 80rears old.

      Like 1
      • Dean W.
      • Dean_W
      • 11 mths ago
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      Van, I am lucky to have good genes as I am only 5 lbs. heavier than my high school weight and my blood tests have always been consistent. For example, cholesterol between 150 and 160. But I would think I have some senescent cells somewhere by now (age 71). My back bothers me and MRIs show disc degeneration which is a very common symptom of aging. I did a Google Scholar search on "Lumbar disc AND senescence" and found several recent articles suggesting senescence might be the reason for disc degeneration of aging. So I continue to try.

      Like 1
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