Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
Let me know how it goes. Like I said before, for senescent cell clearance you really have to be patient. It would likely take 6 months or more to have an appreciable effect. Theoretically when you eliminate bad cells like that you are also removing the signalling that interferes with normal tissue maintenance.
I imagine in the absence of SASP it still takes the body a while to regenerate cells and reorganize tissue back to a more healthy state. It's not something you will notice overnight.
I would like to circle back on the note about NOT taking antioxidants with the senolytic treatments.
So many questions about this!
Stopping how long before?
Which ones are the most problematic?
When can I resume?
How/why is this a problem?
What other supplements might be affected the same way?
In general, should we by cycling all our supplements? Like take this group together for a week, then the other group?
Thanks for all your thoughts!
Well in general I would cycle everything. Take a break, re-evaluate and continue if everything seems ok. I took a week off my NMN supplementation and am about to start again.
In regards to fisetin I imagine it's not as serious a senylotic as some of the other compounds so I'd be surprised if there were any issues with it. What antioxidants are you referring to and what is the interaction we should be trying to avoid with it?
David C Regarding Testosterone boost. I ran across this study showing senolytic treatment reverses age related testosterone decline by killing off sensecent cells in the teste leydig cells.
FOXO4-DRI(senolytics) alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
If this is true, it is huge news as men could start treating their andropause with senolytics rather than testosterone replacement.
Yes I saw this, I commented in another thread about it. This might be true. Ever since taking fisetin the first time I am much more in the zone so to speak . I’d almost call it aggressive, but really it’s more confident. Definitely made women a lot more interesting. I cal also put on muscle fairly fast.
id swear there is something to this. And the effect lasts months after dosing. So I was just thinking I was imagining it a bit. But honestly it’s fairly profound.
I had endoscopic back surgery a little over a year ago. They used a tiny dremmel thru a tube to router out some of the bone that was pressing on a nerve, all due to an aging disc that isn't as fat and plump as it was years ago. In fact I'm about 1.5 inches shorter than I was in my early 20's. The surgery eliminated the sharp pain but my back now is aching all the time, so my use of fisetin is in hope of rejuvenating my aching back. Hope springs eternal. I've just added BPC 157 so I'll keep you informed.
I've taken 2 courses so far of 100 mg Dasatinib, 1000 mg Quercetin and 1500 mg Fisetin. Each course lasted 3 days. I felt nothing (other than the usual headache and runny nose). I think possibly that the more senescent cells you have the more of a rejuvenation effect you will feel when they are eliminated. No science to back that up, just my gut feeling.
Guys, I have a largely theoretical topic/concern. Could there be any damage to healthy cells from the fisetin?
Logically thinking, if it is an anti-proliferative agent, invoking apoptosis, could it non-selectively damage healthy cells also? Like the chemotherapy, which would also damage healthy cells.
Another similar concern is about it being topoisomerase inhibitor, how bad could it really be for the body?
And from the wikipedia, what do they mean by this?
"Like the other compounds, it has also been shown to be reactive in many different assays of biological activities, raising the possibility that any drug generated from fisetin would have too many side effects to be useful."
Andrew Whitfield Fisetin does not "choose selectively" to destroy senescent cells. So why does taking fisetin remove senescent cells? The simple answer is that your own genes remove senescent cells. Fisetin "triggers", "induce", "causes" those genes to activate, when they receive chemical signals from fisetin.
Your body will not get signals from senolytics and start destroying perfectly healthy cells.
The danger is, fisetin is or at least might be toxic at very high levels. So, you look at the safe dosages and how long to take it, the recommended course of taking fisetin.
So as I have mentioned earlier, I am on bisoprolol and perindopril for my hypertension.
Ive just got a Swanson Fisetin 100mg pills, and have tried two dosings, 1 pill and 2 pills in two evenings before sleep. I did not notice any ill effects, and my heart is also fine (HR and BP on usual levels).
I will follow an unusual (safer) approach doubling the dose until I reach 1200-1400. So today I will try to dissolve 4 capsules content in olive oil and take it in the evening.
Will report more later on! :)
Well, I've ordered some fisetin from ebay derived from cotinus coggygria, 98%. Used kitchen scales to measure, so I have put 0.8g to the yoghurt and used it.
After ~1 hour I have felt a bit lightheaded, some minor tachycardia and a boost of energy like from caffeine. A little upset stomach, but very mildly.
I will try 1g tomorrow, let's see how it goes further.
I thank you for your reply first and foremost. I didn't buy it with price in mind but did go the big bag based on price. This came with paperwork saying it was tested and blah blah blah but I bought an RX at Walmart once that I think wasn't what it was supposed to be. The ad on eBay also talks about all the right stuff, agreeing with you on being careful of supplies. It seems to me to be a crapshoot on who to trust these days on anything but especially our own health.
if you would please have a look and tell me what you think.
Hi Fisetin Fans, I just discovered this site and have read all 122 comments which are mostly from David C. Thank you David for sharing your results in detail. I have been following and posting on a similar thread which you might find interesting here:
Here is my experience so far. I am 71 so mostly interested in the longer, slower senolytic effects not the short term ones that David has shown. I used the Mayo Clinic protocol which resulted in 1.5 grams a day for 2 days (based on my 70kg weight). Repeat after one month and again after 6 months. I have tried breaking up the capsules and mixing with olive oil and just taking them with water. Results after one year have been disappointing. Like most people here and on the other forum I feel no positive changes in aging related health problems, of which I have few.
I am concerned about the low bio-availablilty of Fisetin. I've read that the solubility in water is only 0.151 mg per ml. This works out to 571 mg per US gallon so you should be really drinking about 2 gallons of water per gram!!
I know that LE has come out with bio-fisetin that contains a special fiber but they show no links to any science that proves this works although someone wrote here that it was proven. Please provide us a link on that. Also LE has a mix of 3 nutracetils that they call Senolytic Activator but there is no science on that either.
I will continue to search for a senolytic that provides results for humans, not just mice but so far it doesn't seem to be matching up.