Fisetin experimentation one year (reposted as topic for info purposes)

Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways. 

 

To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).  

 

My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations. 

 

So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often. 

 

i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years. 

 

So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely. 

 

As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.

 

I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive. 

 

I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes. 

 

Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon. 

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  • John Ramos One thing seems pretty clear and that is that fats may help with absorption....for both Fisetin and Kaempferol. For that reason, I make smoothies with  the powder with 2 tablespoons of olive oil. I use vanilla flavored whey protein to make the shakes tastier and to get that protein... especially if I use it as a meal. My shakes are varieties of organic berries, including strawberries, blueberries, and red/black raspberries. Plus water, which helps with congealing 

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      • John Ramos
      • John_Ramos
      • 11 mths ago
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      Thomas E Eliopulos Which brand of Fisetin are you taking, I have some bulk but when I did 3g/day for 3 days, I didn't notice anything....Got some coming from Swanson... and Kaempferol is expensive...I'm also taking Quercetin, Luteolin, and Fucoidan among other things...

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  • Yes, I did read David C's posts...

     

    Regarding Fisetin, I bought from a bulk supplier, was the right color, light yellow, supposed to be 98%, sang all the right bells. So, I did 3g/day for 3days with a month off. I felt nothing. Some say the have positive reactions to doing this protocol.

    Here is the interesting thing, I have a supplier in China that I have been buying from since 2015, always the right paperwork and excellent pricing. But, I have to buy 1kg at a time, some of these supplements are ether expensive or so much quantity that that you won't use it in a year or 2.

    Here is their pricing, notice 50%, how many of the suppliers say it's 98%, we may be buying 50% in some cases. Shipping is $35 single kilo.

    For Fisetin 98%,the price is $ 890/kg FOB Shanghai.
    For Fisetin 50%,the price is $359/kg FOB Shanghai.

    I have some from Vitacost(60 caps) which I know to be real, some from Wellness Resources(90 caps) and some coming from Swanson's(60 caps). So far I took the bulk from another supplier, AgeLessExtracts that I didn't have a reaction from but they have 5 star feedback. Doesn't mean it's not good but no reaction in my case.

    What brand are you taking that you're getting a reaction from and what kind of reaction did you get?

    Thanks, John

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      • David C
      • David_C
      • 11 mths ago
      • Reported - view

      John Ramos I use Swansons. Its worked for me from the beginning. So I stick with it. Not saying its the best supplier but I can vouch for this one. 

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  • In addition to my PSA becoming undetectable, I find that colors are a little more intense. This is slight and you might miss it. 

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      • John Ramos
      • John_Ramos
      • 11 mths ago
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      Joe F I wish I could do the same thing with AFP numbers...😟

      We need to wake this forum up, most is from a year ago.

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  • Wake up forum. It has been said that everybody has cancer but when you get older the immune system fails and the cancer runs free. On a different web site many of my fellow prostate cancer survivors developed the cancer when in the mid 40s. Breast cancer can appear in women in the mid 30s. 

    I am Gleason 9/3b but my PSA can't be detected! This is a miracle. 

    I strongly believe taking monthly rounds of fisetin when you are younger just might result in a far better life -perhaps cancer free- as you age. 1 in 7 men will get prostate cancer. 

    Just because you can't notice or feel something after taking fisetin does not mean it was a waste of time. The great benefit might happen later on in life. 

    Like 3
  • Yea this is definitely possible. We just lack the studies to support it definitively. I am glad this has helped you. I lean towards Fisetin definitely being an anti cancer compound just by how it helps clean up the tissue environment.  

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    • John Ramos 

      “icariin impaired the activation of the NF-κB/EMT pathway, as evidenced by upregulation of SIRT6, resulting in inhibition of migration and invasion of breast cancer cells. Additionally, oss-128167, an inhibitor of SIRT6, dramatically attenuated anti-migration and anti-invasion effects of icariin. Transcriptomic analysis verified that impairment of NF-κB led to the selective function of icariin in breast cancer cells”

      My understanding is that Icariin impaired activation of  NF-kB (which promote development of cancer) and upregulated Sirt6.  And  using  a Sirt6 inhibitor (oss-128167) reduce the effects of Icariin. 

       

      Link to the paper in full text

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648025/


       

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      • John Ramos
      • John_Ramos
      • 8 mths ago
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      Staffan Olsson To tell you truth, I don't understand this one.

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    • John Ramos yes I am not sure I can understand the part where they write about (oss-128167) an inhibitor of sirt6. I leave that and don't want to guess what they write. I rest with the understanding that  "the activation of the NF-κB/EMT pathway, as evidenced by upregulation of SIRT6, resulting in inhibition of migration and invasion of breast cancer cells.".

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      • John Ramos
      • John_Ramos
      • 8 mths ago
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      Staffan Olsson I don't understand the inhibition of SIRT6 either, you want to activate SIRT6, Fucoidan does activate it. It's all bunk on Amazon, I use this one Absunutrix  Fucoidan 500mg/cap on Ebay and take 1g/day.

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  • Started this regimen 5 days ago.  1 gram of nmn and resveratrol along with 3 grams of fisetin and 1 gram of quercetin daily.  Plan on dropping back to 500 mg fisetin and quercetin daily but continuing with the dosage of nmn and resveratrol.  I'm a very active 66 year old male in excellent shape, but have experienced a decrease in energy levels over the past several years.  I'm here to tell you, I felt and immediate reaction to taking these supplements, developed a weird muscle twitch in my left forearm that lasted for 3 days, and a tingling burning sensation on the bottom of my left foot!  On the plus side felt a sustained increase in energy, libido, and an overall sense of well being.  I do find it that I don't sleep as sound but maybe I don't need the sleep.  I had given up drinking cause it often left me feeling dehydrated the next morning, but even had a couple of beers the last few days and felt great!  

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    • Van Moore  That's similar to David Sinclair's current protocol except he's also taking spermidine and metformin.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      Kaptain Asia Exactly, not going to add spermidine, but I'm also taking 500mg of berberine 2 to 3 times daily

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    • Van Moore    Let us know how you get on when you reduce down to 500 mg fisetin & quercetin daily.  I am definitely interested in following that as a maintenance dose.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
      • Reported - view

      Van Moore Dosing, it should be 20mg/kilo body weight and for 2 days with a 3 month break.  You don't want to have "0" all the time. Some senescent cells protect against cancer. Get your Fisetin from Swanson and save some money too!

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      John Ramos I've seen studies all over the place, from 2 to 5 days, with varying amounts of Fisetin.  With the life I've led I'm sure I got way tooo many senescent cells and really wanted to do an initial shock to the system. LOL!   Plan on playing it day to day and seeing how I feel.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Van Moore I'm not taking Spermidine either, cost and I don't know if it's adding  enough to justify the cost. NMN, Trans-Resveratrol and AKG are big ones that don't break the bank. From what I've researched, Berberine taken at 500mg per day is sufficient. I can't get Metformin prescribed but I can buy a Kilo for $15, it's dirt cheap. I don't know it they can see it in a blood test, I'm with the VA and they are super careful.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Van Moore The latest I've seen from reputable sources is the 2 days 20mg/day/kilo body weight with 3 months off.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      John Ramos Also began a morning ritual of a 60 to 90 second blast of cold water before getting out of shower.  Have a 400' well and it's really cold!  Really makes u feel invigorated!

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      • Brian Valerie
      • Semi-Retired Health Education Teacher
      • Brian_Valerie
      • 6 mths ago
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      John Ramos One can get what may be a reasonable amount of spermidine from raw wheat germ.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      Van Moore After 18 days of this routine, I've noticed some significant changes.  Muscles feel tighter, feel more limber, less fatique, loss 3 lbs.  I was eating alot of honey with my morning tea or coffee, I completely loss the desire to eat it anymore. Skin and hair feel and look more vibrant, and just feel better mentally and physically.

      Will start the fisetin, quercetin 5 day routine in about another week.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Van Moore Interesting... Have you noticed any improvement in you eyesight? I had 2 pairs of glasses, one for computer and reading and 1 for distance which I had to use for TV, now I can use the computer glasses for both, no long distance, just for outside now.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      John Ramos I'm hoping for that also!  How long did it take for you to notice an improvement?  Over the past 4 years my eyesight has gotten steadily worse.  Had 20/20 prior to that.  Nothing is sharp like it used to be.  I've only been on this protocol for around 3 weeks and have noticed that glare, bright lights, etc. do not bother me as much as before.  Haven't noticed any significant improvement in vision yet.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Van Moore I've been doing it just over a year for 1g/day but went for 1.5g/day for a couple of weeks. The eyesight change really blew my mind. Actually, I hope it's NMN, I take a lot  of longevity supplements, I'll list the good ones.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      John Ramos Please do.  Another thing is that I feel something I'm taking is boosting my T levels.  Had taken DHEA years ago, but gave it up cause felt aggressive and couldn't sleep well.  The feeling now is similar but not as strong..anyway feel that at 66 I need it!

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    • Van Moore I remember reading about dhea and the trick being to take a very small amount. 

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      Robert Olin Probably so, I have recently taken pregnenolone which worked better for me.  Had my hormone levels checked and my testosterone are high for my age.

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    • Van Moore I'm 71 and starting my 1st 72 hr fast on Monday.   This was proceeded by a 25 and 48 hr.   This time I'm adding fisetin and grape seed extract to help rev up the autophagy.     I noticed my back stopped aching after starting some Russian peptides for cartilage called Sigumir.   But its' only been a few days and there's always the placebos factor.

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      • Van Moore
      • Van_Moore
      • 5 mths ago
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      Robert Olin Not taking the NMN, Resveratrol protocol?  

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  • At 70 I have watched generations of people and I can say alcohol causes you to age faster. 

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      Joe F Agree, I've gone for over a year and not had a drink.  I'm talking about a couple of beers a week on special occasions!

      Like 1
    • Joe F Depends on where you get the alcohol and how much. Mileage may vary with your genetics: https://downtoearthzacefron.com/s1-sardinia/

      Like 1
  • My statement is just an unscientific observation. I look at the people my age and those who consumed alcohol have far more wrinkles on their faces and more intense medical problems. Of course the devil is in the details, how much and how often one consumes. Alcohol converts to sugar in your body. Over the course of 50 years that has got to take its toll. The hinges on your front door might last 200 years but if you abuse it you will never attain that maximum. Your hangover is a warning sign that bad things are happening within your body. The bad effects of a greasy bacon cheeseburger can't be negated with a Diet Coke or supplements. 

    My two cents. 

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      • Van Moore
      • Van_Moore
      • 6 mths ago
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      Joe F Agree totally, I only mean that before taking my current regimen having 2 glasses of wine and I'd feel like crap the next morning, so I quit.  Now I feel fine, so something is countering the harmful effects of the alcohol.  Not saying I'm going to start drinking again, but simply that I can.

      Like 1
  • Interesting. As you age you can tolerate less alcohol, a few glasses of wine can give a noticable hangover whereas when you were younger it did not bother you.  I do feel a bit more invigorated after a few days of fisetin. I truly believe fisetin does possess rejuvenating properties.  I can feel it. Vision is a bit more colorful. Perhaps more noticeable at the age of 70. 

    Like 1
    • Joe F There is, of course, an interesting question which is whether improving the health of cells at a cellular level leads to a greater tolerance of alcohol.  I think for me (age 61) that is the case.

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  • Make sure you get  PSA and DRE. Early detection is critical.  

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      • John Ramos
      • John_Ramos
      • 6 mths ago
      • Reported - view

      Joe F Had my PSA done, --> .45

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  •     .45 is good.  Mine was good until 67 then it went way up. Annual after 60 seems to be the way to go. Don't forget the digital rectal exam as a few forms of prostate cancer  don't show up on a PSA test. 

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Joe F I have some cancer that's giving me a high AFP, 3000 at last test. Getting another PET scan the 18th. Have has CT's, MRI's but the PET scan may find it. They can all find different things. And in these scans, anything that lights up would be cancer for the most part. PSA is the least of my worries and since it's .45, I shall not worry. 

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  • Does fisetin help? It does mine but each cancer is very different.  

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      • John Ramos
      • John_Ramos
      • 6 mths ago
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      Joe F I wouldn't have any idea if it helps. I've taken Fenbendazole, for humans it Mebendazole. I suspect that Fenben helped.

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  • Van Moore said:
    Another thing is that I feel something I'm taking is boosting my T levels.  Had taken DHEA years ago, but gave it up cause felt aggressive and couldn't sleep well.  The feeling now is similar but not as strong..anyway feel that at 66 I need it!

     What are you taking for T levels?  What does this mean? The feeling now is similar but not as strong..anyway feel that at 66 I need it!, need what? DHEA?

    I got a list, I just need to massage it a bit.

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      • Van Moore
      • Van_Moore
      • 6 mths ago
      • Reported - view

      John Ramos Yes took DHEA for awhile back in my 40's to raise testosterone levels.  It did, but I didn't feel good at all.  Don't know if the resveratrol, mnm, or fisetin is responsible for raising my levels this time?  Haven't had any blood or saliva tests, but just saying definitely have more energy, and it "feels" like I felt when I took DHEA, but this time not nearly as wired...more of a calm energy.

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      • John Ramos
      • John_Ramos
      • 6 mths ago
      • 1
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      Van Moore Here is the list I promised...Longevity Supplements

      Magnesium Pills 2,300/mg of Magnesium Malate gives you 400mg of elemental Magnesium 98% DV

       ALA – caps 600mg/day

      Fucoidan caps 1g/day Sirt 6 activator

      Glycine powder 1/g/day now, upping to 2g when it arrives.

      Berberine Caps 1,200mg/day, trying to get metformin instead. Maybe someone else can help with this one.

      Ca-AKG powder 2G/DAY

      Fermented Wheat Germ Extract 1g/day, I bought a Kilo, check the prices on Amazon, Hahaha

      TMG powder 1.5g/day

      Trans-Resveratrol powder 1g/day

      NAC 2G/day, I have this in 1g tablets

      NMN powder 1 – 1.5g/day I think 1.5 is more appropriate, you need to take a NAD+ test ($200) to determine, if you taking enough NMN, Richard (Modern Healthspan) took the test and upped his to 1.5g/day, I suspect I would also test the same.

      Fisetin, Caps 20mg/kilo of body weight, 2 days in a row, with a 3-month break, you don’t want to completely clear out senescent cells, having some is beneficial and anti-cancer 

      Apigenin, this is one I’m really conflicted about, 16g of dried parsley is a daily dose, but that’s too hard to take. I can’t figure out a low-cost method of taking this in adequate amounts, maybe some else has a solution?
      Most of the loose powders I take with Trader Joes full fat Honey yogurt  

      All of these have been heavily researched, I’m taking these amounts because of that fact. I hope I’ve covered everything.

      Like 1
      • Van Moore
      • Van_Moore
      • 6 mths ago
      • Reported - view

      John Ramos Thanks!  I'm taking everything but the magnesium, fucoidan, Ca-AKG, wheat germ, and Apigenin.  Will look at those, but was so impressed with glycine that I just ordered.

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      • John Ramos
      • John_Ramos
      • 5 mths ago
      • Reported - view

      Van Moore I just bought it on eBay 2 lbs for $20.69 for 928 grams from Poland. 

      GLYCINE POWDER 100% PURE PHARMACEUTICAL GRADE, NEUROTRANSMITTER, ELEVATE ENERGY

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      • Van Moore
      • Van_Moore
      • 5 mths ago
      • Reported - view

      John Ramos I got 2 lbs off Amazon for 22.41, but will get it tomorrow.  Getting off melatonin, so plan on using at night for sleep aid along with all the other great benefits.

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      • John Ramos
      • John_Ramos
      • 5 mths ago
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      Van Moore Wow, stupid me, I should  have got it there too. Yes, I think melatonin is pretty much a waste of time, take it for sleep, just remember AKG is the big one life extension wise.

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