Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
John Ramos One thing seems pretty clear and that is that fats may help with absorption....for both Fisetin and Kaempferol. For that reason, I make smoothies with the powder with 2 tablespoons of olive oil. I use vanilla flavored whey protein to make the shakes tastier and to get that protein... especially if I use it as a meal. My shakes are varieties of organic berries, including strawberries, blueberries, and red/black raspberries. Plus water, which helps with congealing
Yes, I did read David C's posts...
Regarding Fisetin, I bought from a bulk supplier, was the right color, light yellow, supposed to be 98%, sang all the right bells. So, I did 3g/day for 3days with a month off. I felt nothing. Some say the have positive reactions to doing this protocol.
Here is the interesting thing, I have a supplier in China that I have been buying from since 2015, always the right paperwork and excellent pricing. But, I have to buy 1kg at a time, some of these supplements are ether expensive or so much quantity that that you won't use it in a year or 2.
Here is their pricing, notice 50%, how many of the suppliers say it's 98%, we may be buying 50% in some cases. Shipping is $35 single kilo.
For Fisetin 98%,the price is $ 890/kg FOB Shanghai.
For Fisetin 50%,the price is $359/kg FOB Shanghai.
I have some from Vitacost(60 caps) which I know to be real, some from Wellness Resources(90 caps) and some coming from Swanson's(60 caps). So far I took the bulk from another supplier, AgeLessExtracts that I didn't have a reaction from but they have 5 star feedback. Doesn't mean it's not good but no reaction in my case.
What brand are you taking that you're getting a reaction from and what kind of reaction did you get?
Wake up forum. It has been said that everybody has cancer but when you get older the immune system fails and the cancer runs free. On a different web site many of my fellow prostate cancer survivors developed the cancer when in the mid 40s. Breast cancer can appear in women in the mid 30s.
I am Gleason 9/3b but my PSA can't be detected! This is a miracle.
I strongly believe taking monthly rounds of fisetin when you are younger just might result in a far better life -perhaps cancer free- as you age. 1 in 7 men will get prostate cancer.
Just because you can't notice or feel something after taking fisetin does not mean it was a waste of time. The great benefit might happen later on in life.
Staffan Olsson said:
Just to add to your post...
A recent paper show that Icariin (a substance found in horney goat weed) can reverse the macrobiota of old mice to a youthful state and other positive effects as well. It is an interesting substance and that Icarrin is also a sirt6 activator.
SIRT6 ACTIVATOR - FUCOIDAN Which I take
I noticed in the papers below, they don't say the % strength- I found these...Not Amazon where the strength is about 10%
So, a bit confusing and they say they administered 100mg/Kilo of body weight in mice, that would be a pretty huge amount of the HGWE?
And Icarrin might be useful for females since it inhibits (at least some cell lines of) breast cancer.
“Icariin-induced inhibition( why inhibition of Sirt6?) of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer” Don't you want to activate, not inhibit?
The thought that Grape seed extract contains a substance that kill senescent cells is in line with the findings that some substances in grape seed extracts has been shown to have cytotoxic effects on some prostate cancers.
Started this regimen 5 days ago. 1 gram of nmn and resveratrol along with 3 grams of fisetin and 1 gram of quercetin daily. Plan on dropping back to 500 mg fisetin and quercetin daily but continuing with the dosage of nmn and resveratrol. I'm a very active 66 year old male in excellent shape, but have experienced a decrease in energy levels over the past several years. I'm here to tell you, I felt and immediate reaction to taking these supplements, developed a weird muscle twitch in my left forearm that lasted for 3 days, and a tingling burning sensation on the bottom of my left foot! On the plus side felt a sustained increase in energy, libido, and an overall sense of well being. I do find it that I don't sleep as sound but maybe I don't need the sleep. I had given up drinking cause it often left me feeling dehydrated the next morning, but even had a couple of beers the last few days and felt great!
My statement is just an unscientific observation. I look at the people my age and those who consumed alcohol have far more wrinkles on their faces and more intense medical problems. Of course the devil is in the details, how much and how often one consumes. Alcohol converts to sugar in your body. Over the course of 50 years that has got to take its toll. The hinges on your front door might last 200 years but if you abuse it you will never attain that maximum. Your hangover is a warning sign that bad things are happening within your body. The bad effects of a greasy bacon cheeseburger can't be negated with a Diet Coke or supplements.
My two cents.
Interesting. As you age you can tolerate less alcohol, a few glasses of wine can give a noticable hangover whereas when you were younger it did not bother you. I do feel a bit more invigorated after a few days of fisetin. I truly believe fisetin does possess rejuvenating properties. I can feel it. Vision is a bit more colorful. Perhaps more noticeable at the age of 70.
Van Moore said:
Another thing is that I feel something I'm taking is boosting my T levels. Had taken DHEA years ago, but gave it up cause felt aggressive and couldn't sleep well. The feeling now is similar but not as strong..anyway feel that at 66 I need it!
What are you taking for T levels? What does this mean? The feeling now is similar but not as strong..anyway feel that at 66 I need it!, need what? DHEA?
I got a list, I just need to massage it a bit.
Yes, I do buy Swanson's and take it, it's bit confusing dosing of it. Fisetin is another one that's hard to find the best dosing, 20/mg/kilo of bodyweight is the dose but take it for 2 days with a month or more and what's the proper break? Some say 5 days @ 20/mg/kilo of bodyweight, I'm doing 2 days right now but don't know the proper break.
I also found that taking Magnesium Threonate made a huge difference in clarity of thinking and memory. It crosses the Blood Brain barrier. Dosing on this one is a little murky. I have a kilo, won't run out any time soon.
Funny, just checked & although can search on AMZN for piracetam 800 mg, they do not seem to carry the produce now; maybe previously. But I bought for years the brand sold by IAS, but just now, seems that their I think U.S. store is out of the product. Odd, as this is one of the oldest cognitive drugs. I still have a supply, so have a month or so to find a current source.
Generally, I'm more comfortable buying a name brand on AMZN, rather than from China, or even Indian source. But most supplements there are several top manufacturers on AMZN; I avoid lowest price items. I just doubt that making erroneous piracetam or other items I buy from AMZN is prime area for criminals.
I'm checking with my source, truth to be told, I would say that about 80-85% of supplements come from China, they are excellent biochemists. I have 2 trusted sources that I have been using since 2015.
Check this one out...
Yes, 20 mg/kg for 2 days is what I have been going by too. But I see no results! No difference in the way I feel. (I am 72.) Do you? (Everyone in this conversation should share their age, please, for the benefit of the science.)
This 20 number was arrived at, as far as I can tell, by someone at the Mayo Clinic while planning a long term study. It was probably based on translating a dose from mouse studies to humans which is not an exact science. Go back and read David C.'s rather amazing results. From what he wrote he is now about 45 so maybe just near the age of having senecent cell problems yet he continues to see benefits from the 3 grams for 3 days dose. Fisetin is non-toxic at even higher doses so safety is not a worry.
I use the Mayo dosage of 20 mg/Kg body weight for two consecutive days. I repeat every month and do it twice/month every other month. I saw an immediate 20-25 % increase in my chin ups and pull ups which was quantifiable and great improvement in my color vision which I cannot quantify. These improvements occurred immediately within a day of completing the first two day dose and have not diminished.
I will be 82 in Oct. and started about a 11/2 years ago.
Many others on this forum have reported similar responses to fistin.
@peter_h_how wow, 82 and kicking hard...I'm 76 and headed your way...LOL You've got the right dosage. What all benefits do you feel or notice? I notice some thing about vision, can't put my finger on it. Do you take the fisetin with a full fat yogurt, you should, it's very insoluble. Trader Joes Full fat honey yogurt .
I take the dose on empty stomach first thing in am. Do not eat for 3-4 hours after. Am on ~ 16-8 hr. intermittent feeding schedule-- most of the time. As I indicated my pullups and chinups increased by 25 % ( from 20 to 25) the first day after the second dose with baseline determined in in standard exercise routine. This increase continues to this day. The improvement in color vision-- enhanced colors cannot be quantified. The enhancement occurred the first day after the second dose and was initially noticed due to vivid color enhancement in flowers.
My response may be due to my age, although a number of others in this forum reported similar immediate improvements.