Sources of dasatinib
Hello everyone,
We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy reference and sharing.
The two sources we’re excited about are:
1. MedLab: A pharmacy that will compound dasatinib specifically for your body weight. They offer a customized dasatinib two capsule dose for $225. This represents a one-year supply for most people.
The physician may advise that you take the first dasatinib capsule week one along with the dose-adjusted amount of quercetin and the second dose-adjusted dasatinib capsule week two along with the dose-adjusted amount of quercetin. (Doses are based on your body weight.)
The chart below describes current dosing for senolytic purposes. This requires a prescription and the pharmacy can only ship to Florida addresses. You can contact the pharmacy at 954-400-0560 or email the pharmacist at rxemailbox@gmail.com.
2. International Antiaging Systems (IAS): By July 31st of this year, IAS plans to offer 12 x 40 mg tablets of dasatinib for $99. This represents an average one-year dose that can be individually dosed based on numbers of 40 mg dasatinib tablets you need for your body weight.
For instance, if you weigh 175 pounds, you might want to take 5 of these 40 mg dasatinib tablets to match current dosing suggestions of 2.5 mg of dasatinib per kilogram of body weight. When your weight does not match exactly with the 40 mg dose, members of our private association report taking the additional tablet (making the dose slightly high for your body weight) to achieve desired senolytic effects.
We’ve been told that these dasatinib tablets will be available after July 31, 2019 by logging on to antiaging.clinic (Use password = research, then click the green button saying that you accept the terms and conditions, "T&C", after you've reviewed them).
IAS has pledged to donate 15% of the purchase price from all orders placed on this site (antiaging.clinic) to support human age reversal research. IAS posted this information just a few days ago on the forum here.
While our private association does not have the resources to vouch for these various options, we are grateful that some of our members have independently evaluated (assayed them by an independent analytical lab) them for their personal use, and have then worked with their physician to ensure proper prescribing.
The PowerPoint slide below summarizes dasatinib and quercetin dosing most people are currently self-experimenting with.
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Hallo everybody again,
I hadn't read all the conversation, and now I feel I should be more precise about my visit with Dr. Green of December 2019.
He got me to do the testing in the US. I used
https://www.health-tests-direct.com/ to order and pay for the tests he had emailed me, then I went to Quest (or one can use Labcorp), and they immediately had all my info and drew the blood. After a couple of days, if that, I had the results by email, and I forwarded them to Dr. Green. Before that I had done on his advice the health test included in https://www.23andme.com/en-int/dna-ancestry/ to find out about possible APOE4 problem genes, which I did not end up having. It was good personally to know also about the other genes being mostly ok - even though they might matter up to a point.
I am 69 and my weight is 58, I was found very healthy, with a good HOMA score.
I was prescribed 4 mg of once weekly Rapamycin, of which I got a limited amount in NY. It did not bother me at all while taking it for 15 weeks.
He had also prescribed me Azitrhomycin, 6 Tabs of 250mg to keep on hand just in case, as Rapamycin could lower the immune defence - which it did not. I never got around to order that, but a Canadian Pharmacy did have it.
I actually logged into https://tailormadecompounding.com/, and I assume I could have ordered directly, had I not already arranged with Dr. Green that he would order it for me just for the first time.
It all went well, except that nobody in the US can deliver anything to the EU, not even a US prescription, and I could not get the compounded Dasatinib over to my place (same goes for Rapamycin and Azithromycin), as one could be punished under the criminal law insted of civil law for getting those meds from outside the EU- or one should have a local prescription, which probably doctors cannot give.
So I was also going to take Dasatinib 100mg for 3 days, and Quercetin 1000mg at the same time as Dasatinib, for 4 times a year - for now.
Now the refills.
Through https://www.pharmacychecker.com/ advised by Dr. Green, I could choose which Canadian Pharmacy to use to re-order Rapamycin. I chose https://ycdscc.com/, Your Canada Drug Store, at first, but then decided for IAS, as they operate from London. They would have been a good choice for me if they delivered from the UK but, alas, they deliver from India via Singapore, and I also had the experience of getting the HK account wrong. I got refunded by their bank, but the Rapamycin got me in trouble with the customs, and for now I'm lucky that they have not summoned me to go and see them.
So here is positive information for those in the US, and the UK also, as apparently they accept a US prescription there.
For myself I am at the stage described yesterday.
I had chosen Dr. Green, to be more precise, as he covered the first stages of the 2018 Age Reversal Protocol, although he is in the Age Reversal Doctors because he is the only one to prescribe Rapamycin, but is not actually one of them. Once dealt with TOR and the senescent cells, I could perhaps proceed to other modalites. I am getting corresponding supplements, which I can obtain easily like I said, and will try to do some sort of C.R. if I can. -
Thank you for the details.
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I recently received my dasatinib order (DasaPro) from antiaging.clinic and had no problem except a longer than usual delivery time of about 3 1/2 weeks
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IAS is still out so I think I will give Pravin Lahoti, Varun Medicals , Dasanat (Dasatinib) a try. The cost is $75. 50 mg for a pack of 60 tablets. We will see. If anyone as tried this company please let me know.
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Has anyone submitted dasatanib obtained from https://tailormadecompounding.com to a blinded third party for analysis and confirmation of its purity and potency?
Tailormade provides comparatively inexpensive dasatanib , and based on the post by Flavio Ferlitz, appears to be Dr. Green's current first choice for affordable dasatanib.
If not, any tips regarding which 3rd party would best be able to validate the purity of dasatanib ?
Thank you.
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I have not used or tested their Dasatinib but would trust the quality based on their US location and industry standard compliance. I've used other of their products and they have demonstrated clinical efficacy.
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Taylormade has the best reputation for a compound pharmacy in all the US. I would trust anything that came from them.
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I am pleased that Tailor Made Compounding now offers dasatinib and rapamycin and at reasonable prices. Dasatinib is $3.50 for a 50mg capsule and rapamycin (Sirolimus) is $3.00 for a 3 mg capsule ( 1 mg tablet $9.00, 2 mg tablet $15.00). It is a high quality, well-staffed, licensed American compounding pharmacy that also has an extensive array of peptides, vitamins, and other medications that are useful to this group including hormones. They also provide educational seminars, videos, and information on their products that are emailed to registered physicians. I have had great results with their peptide products and am glad they are now carrying senolytics so I do not have to wonder about a product from or send echecks to a foreign pharmacy (Tailor Made takes credit cards). They ship to most states and deliver in about 2 days.
Tailor Made Compounding
https://tailormadecompounding.com/
200 Moore Drive
Nicholasville, KY 40356, United StatesP : 1 (859) 887 0013
F : 1 (859) 406 1242 -
These votes of confidence are great to hear, though it would be best for any source regardless of reputation to submit to a third party blindly and/or without compensation verify purity and potency - and post this on the corresponding website if possible.
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Hello, Short Intro. 60 years old. Did Calorie Restriction for 10 years followed by another 10 years of Every Other Day Fasting. Started 6mg Rapamycin this past January and recently added Dasatinib/Quercetin (100mg & 1000mg)
My question is: There have only been a few human studies with D&Q. In those studies they used 100mg D and 1000 mg Q for 3 days. So.. where did this dosage schedule of 2.5-5mg/kg dose and schedule come from? Were there studies conducted showing this is the more proper dose than the 100mg for 3 days?
Randy
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The doses are calculated and therefore implied from animals studies.
It is calculated from the animal studies where the amount used for the animal divided by the weight of the animal multiply by your own weight.
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Thanks Andrew, But that still makes no sense. Animal dosages do not correlate straight into human dosages. 2mg/kg for a mouse for instance would not mean a Human would take 2 mg/kg. And why the 8 -12 month period between treatments? Do you have, or anyone else have data that show the senescent cell load dropped and remained low for 8-12 months? If so, please enlighten me.
I'm just trying to find answers in this new and not too researched (for humans) field of senolytics. I've seen the human trials and they used 100mg D. I've seen a few animal trials and still do not know where this 2.5-5mg/kg-repeat in 8-12 months protocol came from. It reminds me of Deprenyl. The standard antiaging dose is 1mg.... but thanks to the cut-n-paste mentality of the internet most everyone that takes Deprenyl is taking a much higher dose than recommended. Is this what is going on with Dasatinib?
The 8-12 month period between treatments is either entirely a wild guess or someone has data that show that the senescent load remains low for that time period from taking the 2.5-5 mg/kg dose.
Randy
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Randy B You know there is the dictum, "First do no harm."
Did you read the side effects of Dasatinib?
http://chemocare.com/chemotherapy/drug-info/dasatinib.aspx
Sure, unlike cancer patients, we don't take daily doses.
Still, following the dictum above, we have to be careful and take it periodically, for example.
You seem to have the idea that we have to remove all senescent cells.
That's a misunderstanding.
We are removing "excessive amounts" of senescent cells.
Senescent cells will send out signals for the body to heal itself with stem cells.
We get rid of excess senescent cells because the body has "limited resources". It can become "overwhelmed". As you age the problem becomes worse.
After getting rid of excess senescent cells, you have to let the body heal. You don't get rid of senescent cells for the sake of getting rid of senescent cells.
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Yes, I have read the side effects from taking Dasatinib on a DAILY basis. This is a mistake most people make.... A weekly dose taken several months apart has no correlation to a daily dose. And I realize we are not trying to destroy all senescent cells, only reduce the burden. My original question still stands, which no one can seem to answer because I have seen the same question posted elsewhere: Where did the 2.5-5 mk/kg dose, taken about every 8 months come from? The 100mg D&1000 Q dose comes from at least 3 Human clinical trials. One of these measured the reduction in senescent cells. Based on these limited human trials we can say that the 100/1000 dose protocol is safe to follow and that it definitely reduces senescent cells. The 2.5-5mg/kg is totally baseless as a recommendation... unless someone can post the studies that were done to prove otherwise.
I'm not trying to be difficult here. I'm just honestly trying to find the best protocol ,and this 2.5-5mg/kg dose seems to have been made up out of thin air and a lot of people are just blindly following along.
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Randy B
Abstract
Background
Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin (D + Q), selectively eliminate senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, D + Q improved physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease, but to date, no peer-reviewed study has directly demonstrated that senolytics decrease senescent cells in humans.
Methods
In an open label Phase 1 pilot study, we administered 3 days of oral D 100 mg and Q 1000 mg to subjects with diabetic kidney disease (N = 9; 68·7 ± 3·1 years old; 2 female; BMI:33·9 ± 2·3 kg/m2; eGFR:27·0 ± 2·1 mL/min/1·73m2). Adipose tissue, skin biopsies, and blood were collected before and 11 days after completing senolytic treatment. Senescent cell and macrophage/Langerhans cell markers and circulating SASP factors were assayed.
Findings
D + Q reduced adipose tissue senescent cell burden within 11 days, with decreases in p16INK4A-and p21CIP1-expressing cells, cells with senescence-associated β-galactosidase activity, and adipocyte progenitors with limited replicative potential. Adipose tissue macrophages, which are attracted, anchored, and activated by senescent cells, and crown-like structures were decreased. Skin epidermal p16INK4A+ and p21CIP1+ cells were reduced, as were circulating SASP factors, including IL-1α, IL-6, and MMPs-9 and −12.
Interpretation
“Hit-and-run” treatment with senolytics, which in the case of D + Q have elimination half-lives <11 h, significantly decreases senescent cell burden in humans
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Randy B Attached is page from a booklet RAADFest 2018 Special Report - Age Reversal Update handed. This page includes the suggested dosing for Dasatinib of 2.5mg/kg bodyweight and dosing for quercetin of 25mg/kg bodyweight. Take once a week for two weeks only. At that time the recommendation was once every 6-12 months. About a month ago in an online presentation, Bill Faloon mentioned that every 3 months may be a better schedule. (I just took 180mg D plus 2000mg Q (on an empty stomach) for the first time a few minutes ago. I weigh 164 lbs.)
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Randy B theantiaging.store has the 2.5-5.0mg/kg recommendation. See attached. This is a page from their online product list.
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Andrew, You are making my point! That is one of the studies that supports the 100mg D& 1000 mg Q. So where are the studies supporting the 2.5-5 mg/kg dose (then repeat 8-12 months later)?
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Randy B
Interpretation
“Hit-and-run” treatment with senolytics, which in the case of D + Q have elimination half-lives <11 h, significantly decreases senescent cell burden in humans
The studies are all preliminary. I only use them as a guide. Like I said earlier, safety first.
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Andrew, I think we are on the same sheet of music... except it is still a mystery as to where the recommendation for 2.5 mg/kg -5 mg/kg came from. I'll stick with the 100d&1000Q dose that I take periodically.
I'm really surprised no one else has chimed in. Surely SOMEONE came up with 2.5-5mg/kg dose. I just don't know who, why or when.
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Randy, thanks for insisting that the dosage be grounded in studies. I have followed Bill Faloon for decades and feel he bases his conclusions on studies and so have just gone along with 2.5 mg/kg dasatinib treatment for myself. But there does need to be the studies to justify that. It is suspicious that there is difficulty finding those studies, but I must say I personally will only start looking now. Any insight from those in this forum as to where that dosage comes from would be greatly appreciated.
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I have just seen that Dr. Alan Green recommends 50mg twice a day for three days and 1500mg Fisetin...three days.... I have no info on his references for this dosing.
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I am currently attending a webinar sponsored by Tailor Made Compounding. the Preventative Medicine Group, and Bio TE, a large practice group that includes use of anti-aging treatments. Here is their senolytic treatment regimen and the study reference:
DASATINIB/QUERCITIN: DOSING
• Dasatinib -50mg
• Quercetin -500mg
• Intermittent dosing recommended with results seen as long out more than 20 days
Every other day for 5 days, every other month
Jaba, T. Dasatinib and quercetin: short-term simultaneous administration improves physical capacity in human. J Biomed Sci. 2019;8(3):3
The regimen recommended on this site of 2.5 mg/kg Dasatinib +25mg/kg quercitin 1 day per week, a week apart, for two weeks can have unpleasant side effects of flu-like symptoms, diarrhea, headache and fatigue for 12-24 hr. These symptoms can be a deterrent to taking the therapy.
The 50/500 dose regimen listed above showed no complications, but provided improvement according to the study.
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GEdward, Not sure what you are reading but Dr Green still recommends this on his website ( as of 3:00pm 13 June 2020)
"My method is use all three:
Dasatinib 100 mg dose for 3 days.
Quercetin 1000 mg for 3 days
Fisetin 1500 mg for 3 days."
And by the way, His recommendations are easy to understand. They are the same doses used in 3 human trials.... where are the peer reviewed articles using 2.5-5mg/kg ?????????????????????????????????????????
David, The issue I have is.. probably the Internet. This is a classic example of someone making a baseless statement that 2.5-5 mg/kg taken every 8 months is the appropriate dose. Someone reads that and cuts and pastes it, and so on and so on. It soon becomes Gospel. Shame of Life Extension Foundation and RAADFest for propagating this unsupported protocol.
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Instructions for taking Dasatinib from Taylor Made Compounding Anti-aging Product Catalog, May 2020-
Product: Dasatinib 50mg capsule
Protocol: Take 2 capsules by mouth daily for 3 days
The dose for quercitin is not given because they do not sell it however they do refer to this article-
Justice, J. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine/Lancet. 2019;40:554-63.
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30629-7/fulltext
The D/Q doses in this article is similar to the Dr. Green dose but is given for 9 doses over 3 weeks. No repeat dose cycles were discussed.
Here is a mouse study where mice were treated biweekly.
SENESCENCE THERAPEUTICS: D+Q
• D+Q have elimination half-lives of<12 h.
• Mice treated with biweekly administration of D+Q starting at 24–27 months of age (equivalent to a human age of 75–90 years) had a 36% higher median post-treatment lifespan and a lower mortality hazard, 64.9% (P=0.01), than the vehicle group, indicating that senolytics can reduce risk of death in old mice.
• Physical function in the last 2 months of life was not lower than that of vehicle-treated mice in males and females.
Xu, M. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24:1246-56.
https://pubmed.ncbi.nlm.nih.gov/29988130/
Has anyone seen a real measure of which dose is the most effective and safest given in what time period? No comparison studies seem to exist. All seem to have good observational results.
A factor is what side effects you can tolerate in daily living with best results. It seems most prudent to start with the lowest dose although intermittent dosing seems universally recommended.
More information will come out as time passes.
