Are epigenetic tests accurate?
I am considering getting my epigenetic age tested via urine sample from the link above and was just wondering whether anybody knows how accurate these tests are?
Is it worth the money to get the test? What do you think?
What's the best company to do it through in your opinion?
Hi Joseph, Betteraging has a very interesting article on their website that breaks down this topic exactly, besides being very informative, it is also extremely interesting. https://www.betteraging.com/aging-science/can-epigenetics-tell-us-how-fast-were-aging/
I'm hoping this could help, and good luck.
A Feb-2020 interview in LongevityTechnology with Dr. Yap Chew of the DNA methylation testing company myDNAge claims: “The median test error for the original Horvath Clock is 3.6 years. Through our research and development efforts we have improved the median test error of the myDNAge Test age prediction to 1.9 years.”
The original Horvath Clock uses 353 CpG sites, while myDNAge uses more than 2,000 CpG sites. The myDNAge test is a bit pricey, with a cost of $299, and it can use either blood or urine. I guess that's still cheaper than the Elysium Index test, which costs $499, is supposed to use more than 10,000 sites, and makes no explicit statements about its accuracy.
I've put together a 1st-try spreadsheet summarizing the commercial DNAm Age testers. They vary wildly in cost and site count. I think Zymo is the standard 2nd gen Horvath DNAm Age test, and the others do their own thing in selecting and weighting CpG sites.
Here's the spreadsheet:
Company Link Sample Type CpG Sites Price EpiAging USA https://epiagingusa.com/ saliva >350 $169.00 myDNAge https://www.mydnage.com/ urine, blood >2000 $299.00 trume https://trumelabs.com/ saliva 9 $99.00 Zymo https://www.zymoresearch.com/ urine, blood >500 $299.00 Elysium https://www.elysiumhealth.com/en-us/index saliva 100,000 $499.00 BioViva https://bioviva-science.com/ saliva 850,000 $457.00
If anyone knows of other commercial DNAm testing companies, (or if the above data needs fixing) let me know, and I'll add it.
I recently received mydnage results. I am one year older than my calendar age. I did Inner Age with Inside Tracker and was nine years younger. Levine calculator is also nine years younger.
My blood draw for mydnage was 2 weeks after receiving 2nd dose of Covid-19 vaccine. Wondering if that had an impact on results. I also had a beer four hours before drawing blood for mydnage.
Huge discrepancy between the two types of tests. I'll retest with mydnage in another 6 months.