Just Ordered Rapamycin w/ No Prescription

When I was at Raadfest18, it was announced that there was a vendor in the Exhibition Hall from whom Rapamycin could be ordered at a good price. Later I found out exactly what vendor from someone central to Life Extension. I went over there, and they said I could order Rapamycin online, and they gave me a coupon for $15 off the regular price. I just successfully ordered it from www.antiaging-systems.com The product is called "Rapa-Pro (rapamycin) and consists of 12 x 5mg Double Scored Tablets. The coupon worked (Code: RAAD15) so I was able to purchase Rapa-Pro for $74.99 plus shipping, which is a lot lower price that available from many sources discussed in this forum. They did not request a prescription. I would suspect something fishy here, except that the person who sent me to them was someone I trust. I will probably start taking 2.5 mg a week, and if I have no unpleasant side effects, I will increase that to 5mg a week. I will have my biomarkers measured first, as recommended in Age Reversal Update, published by the Society for Age Reversal that was distributed at Raadfest18, so that i can hopefully tell if it is doing me any good and also so my personal experience will add to what is known about the use of Rapamycin for anti-aging purposes. If you don't have Age Reversal Update, I'd try to obtain a copy. It describes the specifics of the anti-aging techniques currently available , as well as the order in which they should be pursued to achieve the optimal result.

 

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  • This looks really good.  I did a little research on the seller's website and did not find any big red flags.  I hope it's the real deal.  Please post a followup.

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  • Any updates?

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  • Do you have any updates for the community?

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    • Richard Sapp I had been taking 1mg per day of real rapamycin for an autoimmune condition. My blood levels were slightly low at 2.2ng. I began taking RapaPro from the antiaging store  (after confirming with them that it was in fact rapamycin), at an INCREASED dose of 1.5 g per day. My levels are now lower than the assay can detect. Clearly the product is NOT rapamycin.... or compounded at dosed lower than stated. I suspect that few people taking rapamycin for anti-aging get levels done.

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    • Steve Roedde Thank you for the feedback. Unfortunately, medications are commonly switched or undersized. Anyone purchasing a product from outside the u.s. may want to consider testing. I'm sorry to hear about your results.

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      • BobM
      • BobM
      • 2 yrs ago
      • Reported - view

      Steve Roedde 

      Hi Steve

      can you advise exactly what test this is your doing?

      thanks

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    •  BobM Serum rapamycin levels. I was stable at 2 and 2.1 ng on one mg/day of real rapamycin from a real pharmacy. on 1.5 mg/day of "Rapapro"  I was < 1.5 ng (below testing threshold). My plan is to increase the dose to 2.5 mg per day and retest. That way I will have some Idea of the actual amount in a "5mg" tablet.

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  • Hi, I use lots of the "Pro" products from Profound Products, including MetPro (metformin), RapaPro (Rapamycin), and NalPro ( low dose naltrexone ), and have found them to be just fine.  IAS (anti-agingsystems) is a reliable company, and I've  ordered from them for years.

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  • Serum rapamycin levels. I was stable at 2 and 2.1 ng on one mg/day of real rapamycin from a real pharmacy. on 1.5 mg/day of "Rapapro"  I was < 1.5 ng (below testing threshold). My plan is to increase the dose to 2.5 mg per day and retest. That way I will have some Idea of the actual amount in a "5mg" tablet.

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    • Steve Roedde  Please let us know about further tests.

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    • Patient 139 I will be getting my follow-up test on Monday morning. I have to wait 5-6 1/2 lives of the rapamycin to have a stable trough level. I expect results to be available next Wed.

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    • Steve Roedde Many thanks for sharing your findings!

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  • Steve reported in another thread that the higher dosage still resulted in no detectable sirolimus in his blood. I can only conclude that RapaPro is indeed fake! I thank Steve for his efforts.

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    • Wayne Johnson you are most welcome. I am pasting a comment I made on another thread, because I think it’s important. My experience suggests that there great risks (for me this goes beyond wasted money), in purchasing ANY drug through ANY of these (presumably), off-shore entities. Such is the power of the placebo effect... that I must state that if you have not checked, or been offered real proof... you simply do not know.  “I have done more hard thinking about my experience with placebo sold as “RapaPro” purchased through the AAS. I implied that the store itself is complicit in the fraud. This is possible, but not certain. I know nothing of their supply-chains or who makes their products. Although they are ultimately responsible for selling mis-labelled placebo, it is possible that they have been victims, not perpetrators of this fraud. However, if this is the case, they should provide  clear, transparent, and complete information about how things went so terribly wrong. Until then, I’d have to view any productsold by them with suspicion. As for other suppliers such as Dropshipmd, at the moment, I will go back to the grossly overpriced “Rappamune” and suck up the $12 per mg. I can sell somestuff. However, if anyone can offer evidence that any of these companies sell the real deal, I will be willing to take another risk.”

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      • Larry
      • Larry.1
      • 2 yrs ago
      • Reported - view

      Steve Roedde I used Dropshipmd before I had a prescription and I'm sure that has real rapamycin in it. I can't say for sure about the strength. I know because I tried two "extend" the dose by drinking grapefruit juice (don't recommend) and I consistently got mouth sores. That was two years ago so I can't say if they are still selling real rapamycin. I also rest my weight set point lower with that drug which is further evidence that it's real. 

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      • Larry
      • Larry.1
      • 2 yrs ago
      • Reported - view

      Larry That's "reset my weight setpoint"

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    • Larry That was my first choice... before getting sucked in by a placebo:-). It's almost certain that the Biocon product is real rapamycin. If I can't get the rapamycin covered, I'll try again... once I get my refund from the AAS.... (who is being quite fair).

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • Reported - view

      Steve Roedde I'm not sure how to explain your results, Steve. But I'm confident that RapaPro is indeed rapamycin, though I can't say exactly how much. 

      I'm confident because I have been testing many blood biomarkers for over 10 years. After taking one, 5 mg dose of RapaPro from IAS, I found that my blood glucose, triglycerides, cholesterol, and leptin all went WAY UP; much higher than any test result I have had in over a decade of testing 2-3 times annually. 

      Those of you on this forum that have read some scientific studies of rapamycin know that elevated glucose, triglycerides, and cholesterols are to be expected after taking rapamycin. 

      Moreover, I have experimented with dozens of supplements, different diets, fasting and calorie restriction regimens over the past 10+ years, and I have NEVER had test results (especially glucose, leptin, and triglycerides) like I did after one dose of RapaPro. Moreover, I can not think of any chemical they could have put into the RapaPro tablets to cause these kinds of test result changes with such a small amount of chemical. 

      So I don't know what happened with your test results Steve, but I am confident RapaPro contains a significant amount of rapamycin. Screenshots of my lab test results, before and after RapaPro, are attached. 

      Steve, can you provide images of your rapamycin tests for us to evaluate, as I have done here for my self-experimentation with RapaPro? 

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  • Profound Products has informed me that they are initiating third party testing of RapaPro and will be posting the results on their website. I’m not holding my breath, but...

    I’ ll let you know if/when they get back to me again.

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      • angie4life
      • angie4life
      • 2 yrs ago
      • 1
      • Reported - view

      Wayne Johnson , thanks so much for the update ... I’ve ordered many of their products over the years , most recently DasaPro , and have never had any suspicion that they weren’t genuine .  I use their MetPro (Metformin) every day , their estrogen cream , and used their low dose naltrexone back when it was in stock .  I surely hope not all for naught!

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    • angie4life As an admittedly poor and dangerous test of my suspicions, I took 4 tablets of RapaPro 4 days ago (20mg). Result: no mouth sores, no appetite reduction, no ANYTHING! Sure, I may be an outlier, but I’m not willing to commit any more funds when fasting is proven to yield similar results as Rapamycin.

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  • In 28 years IAS never had an issue and there’s no need to distrust the supply chain. However we’ve halted RapaPro sales in the meantime until the results are in and we will take steps accordingly when we have them.

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    •  CSC When would you expect the results to be available?

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    • CSC So what do YOUR tests prove?

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  • Some of you might find this article...and perhaps the book "bottle of lies" of interest. I listened to a podcast with the author.... frightening! Sadly, at the moment, I would not trust any offshore supplier...or their tests... Unless the testing was done by a reputable body in the USA or Western Europe.

    https://www.statnews.com/2019/07/22/indian-pharmaceutical-industry-drug-quality-charges/

    https://peterattiamd.com/katherineeban/

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 2 yrs ago
      • 1
      • Reported - view

      Steve Roedde I encourage people here to work through their local medical system, and have written up an extensive FAQ on how to get the treatments they need. Working with the system isn't hard, but it does take a little perseverance and I think it's too easy to throw up your hands and go to an offshore supplier without even trying. I've been able to get all of the aging treatments via a combination of local and specialized physicians, for cheaper and easier than other ways. 

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    • Dan Hi Dan. I concur. In my case, I have a mechanism.... I just need to do it... through my family doc... It requires some literature to support the intervention.,..  but I already did that work to convince my doc.... because my neurologist was a cookbook guy and not willing to support my choices....

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  • Update regarding RapaPro

    Official response from Profound Products.

    Profound Products take any negative review seriously because our unblemished reputation for supplying the highest quality products has been hard won over many years, however we know that a good reputation can just as easily be lost by a single allegation on a public online forum alleging that our products are placebos.

    Due to recent concerns from a customer, based upon their blood test results, they determined that there was no active Rapamycin ingredient in the RapaPro product.

    As this has never happened before, we immediately withdrew this product from sale from all resellers whilst we undertook our own investigation.

    We identified the product batch in question and sent a sample to an independent laboratory for analysis.

    The independent laboratory reported back that the product sample provided did indeed contain the active ingredient ‘Rapamycin’, however the amount of active ingredient per unit was lower than we had originally specified for manufacture.

    We therefore followed this report up with the compounding pharmacy who contract manufactured RapaPro and they undertook their own investigation. They reported back that their initial determination was that there had been an unprecedented formulation error and subsequently the incorrect product strength had been delivered to us.

    The product we commissioned for manufacture was specified to contain 5mg of Rapamycin per unit, whereas the independent laboratory test results established that RapaPro contains 3.25mg of Rapamycin per unit.

    We are pleased that this was brought to our attention as a result of this customers vigilance and Profound Products have instigated new procedures on the back of this aberration to ensure that such an occurrence should never happen again.

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    • CSC Neither Steve's nor my experiments indicate that the concentration of OUR batches was anywhere near 3.25 mg. Methinks additional third party, randomly selected, tests are in order.

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  • As it seems that the product was put together by a compounding pharmacy of some sort, it is conceivable that significant pill to pill dose variability has occurred (although it appears that three pills were sampled with ~ 3 mg per tablet). I concur with @wayne_johnson that my pills did NOT have 3.5 mg per tablet because my rapamycin levels were below test sensitivity even taking 2.5mg/day by listed dose (1.75 mg per day if the pill contained 3.5 mg) whereas my levels were stable at ~2ng/dl at 1 mg per day of "Rapamune" brand of rapamycin.

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    •  Steve Roedde I note that antiaging.store is now advertising RapaPro as 3.25 mg tablets. I wonder what they are saying at RAADFEST. I took 30mg of the stuff 4 days ago without any effects. Methinks the lab tests were as bogus as the product.

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      • Larry
      • Larry.1
      • 1 yr ago
      • 1
      • Reported - view

      Wayne Johnson 30 mg should at least give you mouth sores. It would for me anyhow. 

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • Reported - view

      Wayne Johnson Are you doing blood tests before and after taking RapaPro? Taking 30 mg sounds like a very reckless thing to do. Are you purposely trying to harm yourself? The interactions between you and Steve make it seem like you're simply trying to discourage people from purchasing RapaPro from IAS. 

      I'm confident that RapaPro is indeed rapamycin, though I can't say exactly how much. 

      I'm confident because I have been somewhat meticulously testing many of my blood biomarkers for over 10 years. After taking one, 5 mg dose of RapaPro from IAS, I found that my blood glucose, triglycerides, cholesterol, and leptin all went WAY UP; much higher than any test result I have had in over a decade of testing 2-3 times annually. 

      Those of you on this forum that have read some scientific studies of rapamycin know that elevated glucose, triglycerides, and cholesterols are to be expected after taking rapamycin. You'll see that in my attached blood test results after taking RapaPro. 

      Moreover, I have experimented with dozens of supplements, different diets, fasting and calorie restriction regimens over the past 10+ years, and I have NEVER had test results (especially glucose, leptin, and triglycerides) like I did after one dose of RapaPro. Moreover, I can not think of any chemical they could have put into the RapaPro tablets to cause these kinds of test result changes with such a small amount of chemical. 

      Consider my before and after test results below. I know of nothing else but rapamycin that could change my test results so dramatically and in an unprecedented way. 

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    • Max Peto 30mg was merely an increase from 20mg. My only blood test is fasting glucose which hasn't changed. If I were a compounding pharmacy and wanted to increase my profits, I could ship some "oops" batches containing no drug. 

      I trust Steve's actual rapamycin blood levels before your indirect inference data. My absence of mouth sores is just as valid as your side effect data.

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
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      Wayne Johnson I, too, think that Steve's blood level of rapamycin would be compelling evidence, if he could share a page with proper letterhead, date, name, etc. that shows these concerning test results. Sharing a copy of his prescription and the medical condition it is intended to treat would be additional supporting evidence. 

      I don't think your lack of mouth sores is the same quality of data as my blood test results because your lack of mouth sores is not a quantitative biomarker obtained by an objective third party. Anyone can type that on a forum with no one to verify.

      To use your rhetorical technique: if I were a competing seller of rapamycin, I could post on a forum where my competition (IAS) was selling rapamycin and cast doubt on their product by saying I'm taking obscene levels of rapamycin and getting no mouth sores. 

      If Steve's report is verified with documentation, I agree that it would constitute a concerning case that IAS should give a proper explanation for (and they have already given some explanation and even provided a certificate of analysis). 

      Perhaps you are indeed taking 30 mg of IAS RapaPro and there is actually zero rapamycin in the tablets. I'm only encouraging people to expect your claim (and Steve's, and mine) to be supported with evidence other than words. Being careful by using the scientific method can be an important part of what will keep us alive longer and healthier than we may have all thought possible.

      I'm also submitting to this group my evidence against the negative claims about IAS's RapaPro from both my personal experience and my lab tests (which I have measured often for my meticulous personal experimentation). 

      But of course, it's your body to do with what you wish. I hope you don't hurt yourself with such high doses. 

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    • Max Peto I need only eat a high carb meal before fasting 12 hours to get the same increase in glucose and triglycerides as you show. 

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • Reported - view

      Wayne Johnson Wow, that seems like a high sensitivity to carbs. I have consumed up to 600 g of carbs per day, and my fasting glucose 12 hours later has never been above 86 (though I have gotten my triglycerides to just over 100 with excessive carbs). 

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  • MaxPeto @Maximus. My lab results have been posted on the "Sources for inexpensive prescription Rapamycin" Thread. You can review them there. As for my diagnosis of MG,  You can see my positive Acetylcholine antibody test below. I take prednisone 10 mg daily, pyridostigmine 60 mg 4 x daily, Rapamycin 1 mg daily (real rapamycin, at the dose that gave me levels of 2 and 2.1 ng/dl), and intravenous immunoglobulin 75 g IV once monthly. As stated, at both 1.5  and 2.5 mg mg of "Rapapro" my levels were below the threshold of the test. This is not a surrogate endpoint like yours. This is the best and most accurate assessment of rapamycin ingestion.  I have no dog in this fight beyond wanting to protect others from fraud/misadventure. Please note, if I had not posted my results... there would have been no "investigation" which demonstrated reduced amounts of rapamycin in the product. Whether the results are from the same batch I received or a new one... I have no idea, nor do I care. My results were my results. either no rapamycin... or significantly less than 1 mg in a half 5 mg tablet. Satisfied?

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • 1
      • Reported - view

      Steve Roedde I see. Thanks very much for being patient with me and posting your results here Steve. I did not know you had posted these on another thread. Terrific!

      But the results, as you asserted, are concerning (I agree with you). It explains why IAS followed-up with a certificate of analysis and an explanation letter. Your screenshots and your comments make it obvious that you have been taking and testing for rapamycin for some time. 

      Thanks again for sharing with the forum members your experiences, Steve. I will share this with my Age Reversal Network colleagues, who may in-turn talk to people from IAS to ensure this is investigated more carefully. 

      As a representative of the Age Reversal Network, I certainly do not want to endorse any chemical seller that can not convincingly show they are indeed selling what they say they are selling. I think Steve's story and results here cast some doubt on the purity of rapamycin from IAS. Thanks for letting us know of your experiences, Steve. 

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    • Max Peto Most welcome! I'll also state that subsequent to providing IAS my data, and before they did their testing, they offered a refund without  accepting responsibility (which they could  not do without testing).  They have been quite fair with me.

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • 1
      • Reported - view

      Steve Roedde I appreciate your commenting on how IAS has treated you. Good to know. 

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  • But, for the sake of simplicity, I am re-posting three of my tests. One from July when I was taking 1 mg of Rapamune brand once daily and once from August when I ws taking 1.5 mg of "rapamune" brand. Lastly the result from September when I increased my dose to 1/2 tablet daily. Note that the Units are a bit different than in the US. The therapeutic level is for renal transplant patients, and I am hoping to stay just under the lowest transplant level. As I stated before, I'm pleased that CSC did their due diligence after my report. Whether they will recover from this significant problem with their supplier I don't know. Certainly testing every batch from their compounding pharmacy would be a minimum. I have no reason to expect that they perpetrated fraud, just that they received and sold product with minimal Rapamycin.

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  • I, like Steve, was treated very nicely by IAS and given a refund. Profound Products promised to get beck to me to answer my complaint, but I haven't heard from them since. I trust that IAS will be doing their own testing of RapaPro before filling any more orders!?

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  • Recently I had an independent lab (Echelon) compare dasatinib from a US pharmacy with some from an offshore source for purity and content.  Soon will be repeating that process to compare a rapamycin reference sample from Sigma Aldrich with rapamycin from a US pharmacy, and some from an offshore source.

    After the initial analysis is done (which is the most expensive part), you will be able to send your rapamycin samples to Echelon. 

    Cost will probably be about the same as dasatinib, $200-250 per sample.

    Personally, I wouldn’t take a pharmaceutical from an offshore source without first having it tested.  Admittedly I’m a cynic – but one who has heard some bad things and had real bad experience.

    But is offshore rapamycin that less expensive than from US pharmacy?  Understood there is cost and time involved in having a physician prescribe it.

    By the way (and this relates to rapamycin) -- my own dasatinib was filled by CVS specialty pharmacy.   They had me go through a process which included having a physician indicate a diagnosis code.  So he indicated 2019 ICD-10-CM Diagnosis Code R54 -- Age-related physical debility.

    https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R54-/R54

    This should work well for other age management therapies.

    Another associate involved in our D+Q small trial went to a university pharmacy (UCLA), and they just filled the prescription for him much easier.

    While I’m on a roll, here’s what my close circle of associates does to solve aging:

    1) SYSTEM – Self Directed Age Management/Small Study Format
    https://www.aginginterventionfoundation.org/1_SmallStudyFormat.pdf

    2) THERAPIES – Lists of Aging Intervention Therapies

    https://www.aginginterventionfoundation.org/1_UpcomingPersonalTherapies.pdf

    3) MEASURES – Biomarkers, Objective Measures of Aging Therapy Results

    https://www.aginginterventionfoundation.org/1_BiomarkerPersonalPracticalBasicList.pdf

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    • JohnnyAdams Please keep us advised in this space. Many thanks.

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    • Wayne Johnson yes , please , as I haven’t opened my bottle yet !

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    • JohnnyAdams I contacted Echelon and they indicated they did not do lab testing. I would like my rapa (source not listed here) tested. Any suggestions? 

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  • I note that the Antiaging Store is apparently selling their old inventory of bogus rapamycin since they state that it has 3.25 mg of rapamycin.  I personally will not be suckered again, and neither should you. IAS needs to obtain new formulations from Profound Products and subject them to testing before anyone orders.

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  • Everyone -- I do not want to micromanage this, but to avoid problems like @uzoma_iwuagwu 

    experienced, in future I will facilitate or at least give an introduction to the right person at the right "Echelon".  

    Uzomo and others who want their rapamycin, dasatinib or other tested please contact me at 949 922 9786, or email JAdams@grg.org .

    I get no commission or profit -- just helping.

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  • I hope somebody gets a new order of Rapa-Pro from IAS tested per JohnnyAdams post above and posts the results here. I can't afford it - raising two kids on Social Security. If IAS had any integrity, they would do it!

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  • IAS sold me sugar pills and instead of fixing the product, they decided to fix me:
     

    Dear Wayne

     

    Your last email has caused us great concern because you clearly state that you have been taking ‘extreme overdoses’ of the products.

     

    As a duty of care to our customers, we can no longer supply you with any products knowing that you do not take these medications responsibly, under the guidance of a medical professional and are also taking extreme overdoses.

     

    We are there for closing your account with us to prevent any misuse occurring in future with any products supplied by us.

     

    Kind Regards,

     

    The Antiaging Store

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      • Larry
      • Larry.1
      • 1 yr ago
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      Wayne Johnson That's crazy. 

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      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 1 yr ago
      • Reported - view

      Wayne Johnson I don't think their cessation of sending you products is proof that they sent you sugar pills. 

      You were, indeed, discussing on this forum your taking of rather large doses of rapamycin. If I were running a company selling rapamycin without a prescription, I, too, would be concerned that one of my customers may be hurting themselves with my product, which could be bad for my professional reputation. 

      I note that to my knowledge, IAS has not stopped shipments to anyone else. 

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    • Wayne, I agree with Maximus. IAS has to be careful, legally and ethically.

      IAS has been in business for a very long time, and they aren't about to send people sugar pills.

      Like 1
  • Has anybody tried alldaychemist.com?

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    • Wayne Johnson I’ve ordered from ADC for years , tacrolimus , metformin , doxycycline, and just put my second order in for Rapamycin . Dosage is small for the price , but I’m skeptical of ordering from IAS again . I have dasinitib from IAS that I haven’t used yet , and hope it’s legit !

      Like
  • All day is legit but their rapa is dosed small and somewhat expensive for what you'd need weekly. 

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