Rejuvant?

Allen I did the same thing. The Rejuvant product is way overpriced. If someone still wants the ca-akg, they can buy generic version on amazon too for way cheaper.

Fred Cloud @allen_rosenberg

    I don't understand why you guys are continuing to buy and take AKG, when Jimmy2's self experiment (see above) indicated that taking the expensive Rejuvant's AKG-Ca for 4 months had no effect on his DNAme age, as measured by two independent labs  (mydnage and trume).   Are you doing the same thing and hoping for a different outcome?

    Jimmy2's results increase my suspicion that Rejuvant cherry-picked methylation sites that change with their treatment but have not much to do with bio-age.

JGC John, that was only one persons experience. Just because one person didnt get results doesn't mean the entire thing is useless. He may have also been taking something that cancelled it out such as metformin like he mentioned. I have heard from other people that did get results so all hope is not lost. So I wouldn't rush to judgement until you hear many other people not getting results.

JGC I also have reports from people taking Kirkman's Ca-AKG product along with berberine who reported reduced methylation age as per their Trume results. So Jimmy2's results are not undisputed.

JGC I am still taking Rejuvant, if though it didn't affect my biological age.  I think there is something else I am taking that is interfering with it.  I am going to adjust my stack and report back.  I do believe that it increases healthspan, if it doesn't decrease biological age for me, yet.  It also increases the oxygen carrying capacity of red blood cells so I can exercise for longer.

Here is another study that also uses AKG along with many, many other interventions that reduced biological age: https://www.longevity.technology/wind-the-clock-back-three-years-in-just-eight-weeks/

Research is still new so hopefully we can hone in on what is truly working.

Jimmy2 

    Maybe I'm just paranoid, but I think "trust but verify" is a good strategy when dealing with commercial bio-tech testing outfits.  In that context, I have a question about your DNAme age tests: Did you tell them your true calendar age when filling out the orders for the tests?

    My wife and I recently did DNAme Age tests with EpiAging.  In placing the orders, I avoided divulging our calendar ages (even though they asked for them.)  The results (see LINK) came back with my DNAme age less than my calendar age by 23.6 years and hers less by 14.3 years.  It is devoutly to be hoped that our use of anti-aging supplements (metformin, rapamycin, resveratrol, curcumin, spermidine, GLA, ...) and our periodic D+Q+F+P senolytic sessions have actually made us biologically younger by those spectacular amounts, but I'm skeptical.  I wonder if it could be that some or all of the DNAme testing laboratories are "dry-lab-ing" their results to put them within a few years of calendar age, if it is known.  I think that when doing such tests, one should give the testing lab as little age information as possible.

JGC Good point.  For my next DNA test I will create a new identity and avoid revealing my age.

JGC As I reported earlier, my EPIAGEING DNAme age test  was 22 years younger than my calendar  age (80) and I did provide them with my calendar age. I did have some issues with their bookkeeping,  but do not know if these issues extend to the laboratory.

JGC At this point, I think the scientific evidence outweighs an anecdotal report. Excluding Rejuvant, the cost of AKG is low so why not give it a try?

JGC I felt the same exact way when I ordered my methylation test from mydnage.

They asked my age before the test and that screamed red flag for the same reason you expressed, I thought what is to prevent them from dry labbing the result close to your age and pocketing the money? So I told them I was 99 years old, they called me in a panic when my result came back in the 50's. I told them there was no way I was giving them my real age before they gave me the result, they were so confused, they couldnt even understand the concern. I sent several emails to their execs, and they couldnt understand my concern. It was very strange.

Allen My wife had ocular shingles and traced it to the arginine supplements she was taking for growth hormone release.   Young body builders are coming down with shingles by over doing arginine supplementation.   So  there is AAKG and AKG.  Does AKG have any arginine in it?

Robert Olin

"Arginine bioavailability is absolutely necessary for the replication of herpes simplex virus, which causes cold sores/genital herpes. When arginine is not available, herpes viruses in cells are unable to complete a single replication cycle and cell damage is evident in infected cells".

"Herpes zoster ophthalmicus is reactivation of a varicella-zoster virus infection (shingles) involving the eye"

But Calcium AKG doesnt seem to cause such problems.

chuck stanley    The product we have is Double Wood  Supplements   AKG.   There is no mention of calcium or arginine.    If it had arginine wouldn't it say AAKG?

Thanks.

Bob

Robert Olin  I dont see arginine anywhere in their ingredients list. I cant think of  any reason that arginine would be produced by any other form of AKG. But I'm only familiar with the Ca AKG which if I recall was the product used in the studies, so thats the one I use. Since virtually all or nearly all of us have some sort of herpes virus living in us, I expect we would have heard of any adverse reactions to the Ca AKG.

I was curious so I contacted Doublewood and the rep wasnt able to tell me the source of the AKG. I hope to get an email response. At this point, since she did tell me the AKG was not from Ca AKG, I would assume it is from the arginine- AKG.

chuck stanley   Thanks so much.   So it appears then, that AKG comes in one of two forms - calcium and arginine.    I've heard that if you do take arginine you should also take lysine to balance it.

Robert Olin interesting point. If you are supplementing with arginine for its benefits you probably wouldnt want any extra lysine competing with it.

chuck stanley If the Double Wood AKG has arginine my wife can't take it but I can, however, the lysine might help.   I've never had shingles but my God it can be painful and leave you with lasting nerve pain.   I've scanned the net and can find nothing that repairs the damaged nerves.   My wife has to take seizure medicine to live with it.  It's driven some people to suicide.  

Robert Olin well, it might not have arginine in it after all.

Here is what it says on Amazon about the product: "Different than AAKG - AKG is not be confused with AAKG. AAKG is a combination of Arginine and Alpha Ketoglutarate which AKG is pure Alpha Ketoglutarate." So according to that statement, its not the salt, but the  pure AKG.

That statement by itself would be reassuring, but it also says: "Nitric Oxide Booster; AKG may act as a precursor for both arginine and nitric oxide to help boost levels of both" Sounds pretty ominous. I'd be afraid of it myself.

Maybe the Ca AKG is a form that doesnt have that effect.

If I get an answer from the manufacturer I'll post it.

Robert Olin I knew someone years ago who committed suicide because of shingles. He was young, maybe not even 30.  

JGC does the p in d+q+f+p stand for piperlongumine?

Chuck Frasher 

    The P stands for Piper Nigrum in the form of Swanson BioPerine ($2.86 for 60 x 10 mg caps).  It is intended to increase bioavailability of flavenoids like Fisetin and Quercetin  by suppressing the presence of P-glycoprotein in the small intestine.  We take it an hour before the other items in D+Q+F+P to give it a  chance to do that.

    See https://www.isotrope.com/bioperine/ .  It says that: "P-glycoprotein is a protein the body uses to break down exogenous compounds found in the body. This protein inhibits the action of many medications, and also regulates the degree to which certain nutrients are absorbed by the body. This protein actively controls the permeability of the blood-brain barrier, which directly impacts the overall effects seen by many compounds such as curcumin—the active compound found in Turmeric. Piperine inhibits the action of this protein."