Has anyone heard of this?
The speaker presented a talk indicating that users got substantial drop in DNA methylation age results - I seem to recall an average of 8 years after 6 months usage
I've found Ca-AKG with widely varying prices. Rejuvant apparently charges a high price for controlled-release tablets (1000 mg daily) and Alive By Science likely charges a high price for a Powdered Liposomal Calcium Alpha-Ketoglutarate with better absorption (900 mg daily). Finally, Prohealth Longevity apparently offers Ca-AKG very cheaply at $18.52 for a month's supply (1000 mg daily).
Well, $110-$149 monthly for Rejuvant, $48.95 monthly for Alive By Science or $18.52 monthly for Prohealth Longevity?
Does anyone know (for sure) if the Prohealth Longevity product is vastly worse than the others? Or, are the other two products vastly better than the $18.52 monthly product? Are we dealing with any form of snake oil, high class or otherwise, here?
Will this CaAKG be of good quality? 1KG for 50 dollars.
Is there any reason to think that Arg-AKG wouldn't work as well as Ca-AKG? These are both salts of AKG. Arg-AKG is much cheaper and has zero taste compared with Ca-AKG. I switched about 9 months ago after beginning Ca-AKG in Feb 2021.
At the switch I did a calculation on MW of Ca-AKG vs Arg-AKG to follow on my back-of-envelope calculation on the 2% w/w in rodent chow in the Kennedy study to see if I could get about the same amount of free base AKG (using the debatable rodent/human per kg adjustment) as the rodents in the study.
I do 8.5 gr of Arg-AKG daily in one dose (too much trouble to break it up across the day) dissolved in water or bone broth. Hard for me to say if it is having some beneficial effect. I added NMN/resveratrol a couple of months later, and I am not much for subjective reactions anyway.
Bodybuilders have been doing Arg-AKG for years at that dose or more based on some nitric oxide muscle building hypothesis that doesn't appear to be demonstrated conclusively.
I have a strong stomach, but even in capsules the free base form (from Double Wood) was a little nauseating for me (I was surprised to even notice), and releasing it from capsules was god-awful tasting.
To get 5 gr AKG per day (my goal from reading the Kennedy/Buck Institute study paper doing calculation as described above) would be a lot of capsules and cost a lot. I think 5 gr is conservative compared to what the rodents got. I forget how much they are dosing the humans with in that NUS clinical trial Kennedy is doing at his new gig in Singapore.
Which methylation clock did you use? Like most epigenomic stuff, they all give different results is what I have heard (not surprising). And what was your dose regimen?
As mentioned above, I have been doing 8.5 gr Arg-AKG daily for 9 months (since about June 2021). Before that, I did whatever the equivalent is of Ca-AKG for about 4 months (Arg of course has a much higher MW than Ca). The calcium salt costs a lot more than the Arg salt, and it didn't make sense to me that the Arg salt wouldn't just dissociate in my gut and work the same as the Ca salt (used in the Kennedy study in dry chow). And if there is anything to the body builder lore about nitric oxide and muscle growth with Arg AKG, I have that covered with 2x/week strength training, too. My buddy at UC Irvine who'd told me initially about the Kennedy study only does the Arg-AKG on days he lifts, but I am going daily because it's cheap, easy, and no way it can be harmful.
I did the Horvath test licensed by Zymo Research (DNAge) last April or so to check methylation, a couple of months into AKG but just before starting daily NMN-NR-resveratrol-pterostilbene-quercetin. However, any epigenome methylation results now will be confounded now by 1 gr daily resveratrol. I will look into the Levine stuff, thanks for that.
Like I said, in my opinion 5 gr AKG is conservative based on the Buck Institute study and using the available conversion factor for mg drug/kg BW dosing in humans vs rodents (I weigh 75 kg). The Kennedy study fed ad libitum, not dosing with precision like a clinical trial, so no way to know the mg weight of AKG consumed per gram weight of rodent....although they got around any timed-release issues that way, I guess.
However, I made rough estimates based on the 2% w/w in the dry chow used and the presumed weight range of the rodents. I can't remember right now if they were mice or rats, but I went through that paper with a fine-toothed comb at the time in doing my calculations, even did a blog post on it for a client.
Ideally, I would put the Arg-AKG in water and sip at it all day (I put it in my dog's water bowl, so that is how she gets it), but I don't drink water that way (dispersed) unless I am on a bike ride for more than an hour. Otherwise, I put it in bone broth (along with my daily dose of creatine) that I hope is not messing too much with time-restricted eating....not to mention the Sinclair-recommended tablespoon of full-fat yogurt for resveratrol absorption (that I mix with a tbsp of fish oil for even more fat-enabled bioavailability and a good opportunity to hit omega-3s hard daily).