Rejuvant?

Paul_Beauchemin
5 yrs ago
142replies

Has anyone heard of this?

The speaker presented a talk indicating that users got substantial drop in DNA methylation age results - I seem to recall an average of 8 years after 6 months usage

- Paul_Beauchemin
- 5 yrs ago
- Reported - view
forgot to mention was presented in Longevity 2020 conference 5/1/20
- Fred_Cloud
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin Is there a video clip out there of this? I looked but didn't see it.
- Staffan_Olsson
- 5 yrs ago
- Reported - view
I have not seen much information regarding Alpha-Ketoglutarate and its potential for agereversal - improving healthspan. But I have seen a lot of Alpha-Ketoglutarate in formulas that focus on improving physical peak perfromance in sport.
- Paul_Beauchemin
- 5 yrs ago
- Reported - view
Here’s a summary of CEO’s talk. Claims are quite impressive

https://www.longevity.technology/rejuvant-shows-positive-early-results-in-humans/
- Staffan_Olsson
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin They use calcium Alpha-Ketoglutarate monohydrate, 1000 mg daily. yes they report intresting resluts.
  
  Here is another report from a mice study.
  
  https://www.biorxiv.org/content/biorxiv/early/2019/10/04/779157.full.pdf
  
  it seems like the major effect is compressed morbidity and increased healthspan rather than increased lifespan.
- Staffan_Olsson
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin I found this paper about CaAKG. Calcium-Alpha Ketoglutrate is to find. Have someone else here had better luck?
  
  https://www.sciencedirect.com/science/article/abs/pii/S1550413120304174
- David_Hanson
  
  5 yrs ago
  
  Reported - view
  Staffan Olsson I found this one with a google search:
  
  https://www.supplementplace.co.uk/calcium-akg/
  
  Free international shipping if you spend more than 50 pounds.
  
  Disclaimer: I have never purchased from them. Buyer beware as usual.
- Staffan_Olsson
  
  5 yrs ago
  
  Reported - view
  David H Thank you David! Much appreciated.
- Iunn
  
  5 yrs ago
  
  Reported - view
  Staffan Olsson Does anyone have a copy of the full text of this paper? Would you please attach it to a post?
- Staffan_Olsson
  
  5 yrs ago
  
  Reported - view
  Iðunn This is the full text.
  
  https://www.biorxiv.org/content/10.1101/779157v1.full.pdf
- Iunn
  
  5 yrs ago
  
  Reported - view
  Staffan Olsson Thanks. I was actually aware of that. That's of course the preprint, not the text as it was finally published (let alone the formatting changes); would anyone please post the final, published journal version?
- Staffan_Olsson
  
  5 yrs ago
  
  Reported - view
  Iðunn AS far as know they published it yesterday in cell metabolism. But not the full paper. And it is not a free version.
  
  Cell-metabolism
  
  Short Article| Volume 32, ISSUE 3, P447-456.e6, September 01, 2020.
  
  https://www.cell.com/cell-metabolism/pdf/S1550-4131(20)30417-4.pdf
  
  I guess we have to keep looking for the full text.
- Iunn
  
  5 yrs ago
  
  Reported - view
  Staffan Olsson That is the full text — but behind a pay-wall. I was hoping someone had access to a copy (university students and staff, etc). Thanks for following up.
- Fred_Cloud
- 5 yrs ago
- Reported - view
Paul. I found this one study on AKG antiaging effect.

"In males, diets containing 10 mM AKG increased maximum lifespan. Diet with 20 mM AKG shortened median lifespan and had no effect on maximum lifespan of males."

http://ukrbiochemjournal.org/2018/11/effects-of-alpha-ketoglutarate-on-lifespan-and-functional-aging-of-drosophila-melanogaster-flies.html
- Fred_Cloud
- 5 yrs ago
- Reported - view
Paul Beauchemin I found this study. Now this is interesting AKG shows life extension because it inhibits Mtor and activates AMPK. So thats good news and bad news. Good news because it is acting like both metformin and rapamycin life extension pathways. However the bad news is that it doesn't seem to be working by rewinding the methylation clock.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629006/

I will keep looking but I really don't see much. If this stuff is so great, shouldnt people be talking more about it and touting it for its antiaging properties?
- Paul_Beauchemin
  
  5 yrs ago
  
  Reported - view
  Fred Cloud lots of people talking about it now, including David Sinclair https://www.biorxiv.org/content/10.1101/779157v1.full.pdf
- Fred_Cloud
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin Interesting, thanks for posting this. I wonder if anyone here has confirmed methylation age reversal from taking it? They say it only take 6 months, I think we have been discussing it that long on here. Are you on it?
- Iunn
  
  5 yrs ago
  
  Reported - view
  Fred Cloud I respect the hell out of Brian Kennedy and Gordon Lithgow, and the animal study is very interesting. However, the epigenetic age clock used in the PDLH "study" is really shoddy and has not been validated; I would ignore that part and wait for the human studies from Kennedy at the National University of Singapore or via PDLH at Indiana U.
- Paul_Beauchemin
- 5 yrs ago
- Reported - view
Fred Cloud Brian Kennedy spoke at an online Longevity conference in London in March of this year. It was free to watch live but they charged for links to the replays and I did not buy the replay. His talk was featured along with top longevity scientists so it seems odd if this was a scam
- Fred_Cloud
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin I see, well doesnt it seem odd no one is talking about this? Why the disconnect. A supplement that can rewind the methylation clock? That's huge news and the only one talking about it is the company promoting it. That seems strange. Everyone made a huge deal about Dr Katcher's breakthrough. This would be even bigger than Katchers announcement, as it is available now, no regulatory issues, just go down to the store and buy this supplement that has been sitting on the shelf for 30 years in health food stores and it can rewind your clock.
- Iunn
  
  5 yrs ago
  
  Reported - view
  Paul Beauchemin
  
  Paul Beauchemin said:
  Brian Kennedy spoke at an online Longevity conference in London in March
  
  Would you please link the website for this conference, and ideally the Kennedy video or related materials?
- Jim_N
- 5 yrs ago
- Reported - view
How long did it take for Nicotinamide Riboside to become accepted? Could this be the newest supplement to take for longevity?
- Jim_N
- 5 yrs ago
- Reported - view
This is strange and was in the FAQ on their website:

Can I take Rejuvant with multivitamins?

Based on our data, taking multivitamins or other supplements that have many ingredients might not have additive effects. Because of this, we recommend taking Rejuvant apart from other supplements and vitamins.

Do I really need to stop taking multivitamins?
- Iunn
  
  5 yrs ago
  
  Reported - view
  Jim N There are a number of rodent lifespan studies and human epidemiological studies suggesting decreased rather than increased lifespan from multivitamins (especially high-dose multis like LE Mix); it seems best to target specific nutrients you need and not throw a huge load of every nutrient at everyone and then megadose something like AKG on top of that — and their results support that.
- Peter_H_Howe
  
  5 yrs ago
  
  Reported - view
  Iðunn Could not disagree with you more on your LEF multivitamin statement. I have been taking LEF multivitamin for 20 + years. Also follow LEF's recommendations on a number of supplements and hormones. You can always find a study or two which makes a false conclusion based on bad study design.
  
  I will be 80 in OCT. MY AI 2.0 and AI 3.0 were 25 and 29 years old respectively for a May, 2020 blood test. My Levine sspreadsheet for the same bloodwork calculated a Ptypic age of 73.42 and a DNAm of 71.8.
  
  I had emergency bypass surgery based on angiogram over 26 years ago. The probability of my being here 26 years later is less than 5 %.
  
  Thank you LEF

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