How to increase the bioavailability of Fisetin

JGC Bioperine certainly increases the absorption of curcumin, although maybe not of the parent compound, but I don't think there's any evidence that it increases absorption of flavanoids across the board, or fisetin specifically — can you cite any?

JGC 

I lease let us know about your success with dissolving this product in warm olive oil.

I was not successful in doing it with the Dr’s Best capsules...

BobM 

I had absolutely no problem in dissolving my Swanson Fisetin (Novusetin), 1 gram in 1 Tablespoon of room temp olive oil.  I also dissolved 1 gram each of Quercetin and Curcumin in the same oil.  Why are people having problems with this?  Yes, if there are fillers, they won't dissolve.  Both Swanson and Dr's Best should be the same Fisetin (Novusetin), unless they are adding fillers.

Dan Nave 

This is very interesting Dan. I will have to try Swanson Fisetin!

JGC I did a large dose Fisetin last Saturday and Sunday. I did the Mayo Clinic dosing guide and added Bioperine and olive oil.  On Wednesday I had a blood workup.  Nothing fancy just a liver/kidney function test with Auto Differential.

My total WBC is low measuring 2.5 plus high Eosinophils at 9.3% (indicating Eosinophilia) and high Lymphocte at 45.5%. I do not have an infection that I am aware of so these numbers could point to serious diseases like leukemia, cancer, or an autoimmune disease just to name a few.  Can a Senolytic dose cause these values?

My doctor ordered a redo but I need to wait a couple of weeks.

Thanks

JOHN one of the common side effects of another senolytic, dasatinib, is low WBC. It's probably the same for fisetin at critical doses; I believe the white blood cells are depleted due to dealing with senescent cells. Some people get flu-like symptoms from senolytics, so your body is probably reacting like you have an infection.

Definitely do the follow-up test, but I wouldn't be surprised at all if your numbers are fine the second time around. If you're comfortable with sharing those results, please do, as it would be interesting to have confirmation.

Ajax My follow up labs are as follows:

total WBC: 3.7

Eosinophils : 4.1%

Lymphocte: 33.7%

A little low but I have historically tested low for WBC in some years previous.  The Eosinophils and Lymphocte's have never been so high though. 

JOHN Yeah, both Eosinophils and Lymphocytes are toward the upper end of normal, though obviously things improved quite a bit since the first test. I'd expect any fisetin effect to be gone by the second test, so I'm thinking you may have some other low level contributor. e.g. inflammation, asthma, low vitamin d. It's also entirely possible it takes longer to return to a normal white blood cell balance after a senolytic treatment, compared to a typical infection.

Thanks for sharing the results!

JGC I think a person should be very careful about doing anything that will increase the permeability of the blood-brain barrier.

JGC  Hi, do you have any updates on your experience taking Fisetin? I got some DMSO and looking for to use it with the Fisetin and maybe black pepper too, this should increase absorption. Will report back, but will take awhile.

Danh Tran 

My wife and I did three senolytic sessions involving about 5,000 mg of Fisetin each last October/November (as described elsewhere in this Forum), and we have taken none since.  In the last two session we took 10 mg of BioPerine (the equivalent of your black pepper) an hour before the Fisetin capsules to increase bio-availability.  I experienced only a few minor side-effects in the 24 hours after the doses.  We both felt well after the sessions, but our bloodwork showed only fairly small improvements.

We plan more Fisetin (and D+Q) sessions in the near future, but this plan has been delayed because I have recently had cataract surgery and lens replacement in both eyes (I'm now 20:15 for distance vision).  It is well known that senescent cells play a role in healing, and senescent cell clearance interferes with and delays healing from surgery.

After I suggested dissolving Fisetin in DMSO, I received comments from some bio-experts saying that while it had not been tried, but it probably wouldn't do much.  However, I think it's worth a try, and I will be interested in your experiences.  I note that others have found that one can break open the Fisetin capsules and dissolve the power in olive oil before tasking it orally.  I have just ordered some >98% pure Fisetin powder from VitaSpace, and we plan to take that powder dissolved in olive oil in our next sessions. 

JGC I read up DMSO and HGH, I was interested in HGH without having to needle myself. Found this article, which has interesting information which could also work for Fisetin. http://www.youngagain.org/d6.html

Basically HGH dissolved in DMSO will not absorb thru the skin but will if place under the tongue. 

I take B12 and this is how they tell you to take it on the label (place under tongue).

@JGC Danh Tran 

Yesterday I added DMSO to my dose of Fisetin, held it in my mouth between gums & cheek for about 30 seconds, then swallowed.  No problems.

• Fisetin, 400 mg - Doctor's Best capsules -- opened to remove powder
• Bio-Perine, 10 mg, capsule -- powder mixed with the Fisetin
• Coconut oil, liquid, about 20 ml, to dissolve the powders
• DMSO, 10 drops

Mixed together with a wooden chopstick in a tiny shot glass (whiskey glass, but no whiskey).   I read somewhere that DMSO will dissolve metal or plastic, so I am using glass and bamboo.

No problems, so I'll do the same this evening, increasing Fisetin to 500 mg.

I read above on this thread about reactions to large doses of Fisetin, so I decided to determine my dose by increments.  Started five days ago with 100 mg, adding 100 mg/per day.  Today, day five, will be 500 mg.  Then will pause for a month before the next round.

Mike Almerjanski 

Mike Almerjanski 

Mike Almerjanski That's great. My method will be to dissolve black pepper w fisetin (99%) in DMSO and use a glass dropper to put it under my tongue. I think this is the best area for absorption. I'm  going for 3g at a time for 3 days. I'm waiting for my calendar to be clear. Should be soon.   Actually mnight not need too much pepper or at all, since it's going directly into the blood bypassing the stomach.

Will report what happens. Will kick it up to 5g next time, if everything goes well. Read some posts where that was how they got the best results.

Danh Tran 

can you update us on how Fisetin dissolved? How much were you able to get dissolved, in how much solution? How?

thanks!

BobM  ok. I definitely will. I'm traveling now. I think it's not even any kind of risk if you take as much as you can to get results. Safer than most "approved" drugs. It's not even a drug, so who cares. Oxy etc. That is 1k times more dangerous. Can you die or get addicted to fisetin. NOT

BobM I easily dissolved 2 grams in 8ml of DMSO. I think I could have used 5ml. It tasted horrible in my mouth. I chased it with carbonated water, not much help. Milk w a bit of sugar worked pretty well. 

BobM 

Danh Tran one pile is 2grams. Could dissolve in 4ml of DMSO. When I mixed it with 1/2 cup of milk the fiseten absorbed the milk like a sponge and it almost became solid. I sucked it down without mixing it too much. Today I just did a shot of 4ml w fisetin straight down with a chaser of juice. This was a lot easier than swishing in my mouth, which tasted so bad and was unbearable.