Rapamycin Cost

Thanks to the team and inputs here:

Another data point with the China Purchase of 10 grams for $660 includes the shipping cost. Obviously a couple people for a couple years each, a dog and for skin cream development. Male 60 and Female 53 in good health, no other meds, I'm athletic, she is not, looking for weight loss for her. My mom is 87, no meds, all her friends are dead, she still drives and works out with a trainer. She will also be on this for an old lady data point. On its way, should be here soon and will update if something happens.

Have 0,1mg scale ($300) range, simple cylindrical rock tumbler that I will use to perform extended mixing with red pill excipient off Amazon. I will also use gel caps Size 5 and a small hand unit to fill them with the 2,5-5 mg Rapa per dosage mixture I come up with. Have already looked, 1mg is infinitesimal amount of powder so will have to make a big batch to even fill size 5's.

I ran the stats on the small gunpowder scale and it is not doing so well, so I made sure to spend extra on the balance above to get something within the target measurements capability. Otherwise you have to make excessive batch sizes to be sure to be within 10%,,,,as I see some don't care about more than 10% dose difference, should be OK. The smaller the batch, the less storage issues I think?

For the cream, I will dissolve the Rapa powder in Vodka and add to a few mixes of coconut or other oils. May do DMSO or other solvents, those are mentioned in the patents. Even just heating may be enough to melt it, so we will see. But in a solvent it should be much easier to mix evenly into any oils. I always add a drop of oregano oil to make sure Im mixing clear contents up properly.  Any other ideas on the cream? Crazy the number of patents with every conceivable delivery system or process for Rapa. Stents, Bone, heart, brain...everything pretty well covered, a lot of money to make, so I expect this to be the new vitamin next decade ;)

Thanks again to everyone for the honest discussions.

I'm going to get another 1g sample from the Alibaba supplier and give the skin lotion a try... I don't think accurate measurement is all that important, Blagosklonny implies that Rap isn't toxic and most likely can't overdose on it as he references a case where a woman tried to unsuccessfully commit suicide by downing 100 1mg tablets with no effect.  I think I'm just going to get a micro spoon and try to get a "pinch" in it Lol and just mix it up in the palm of my hand with my favorite face conditioning lotion and apply.  Just not sure how frequent to apply it, I'll read the article and see what the protocol was for the study.

I just received my second order (same supplier as my first) ...10.48 grams... for ~$650 Canadian. At the price I was paying for "Rapamune" brand in the local pharmacy... over $100,000.00 Canadian. I had been a bit concerned about supply chains... anyway, it's happy in my freezer. As before, I'll compound it, take it (back to my 1mg per day dose) test my levels, and if they are the same as all of my initial tests at that dose, I'll assume it is the real deal. Of course they supplied a COA... but I no longer trust any supplier... but my confidence in the one I have used is growing.

Just received my 10 grams, awaiting some #5 capsules and capsule loading apparatus. 

Skin cream: I looked up Dr. Green's site and he has been formulating his for his solar keratosis with 15mg/oz in Aquaphor cream. So I wanted something a little weaker and easier to work with so I used 10mg/oz, each tiny amount on my smallest stainless spoon is 3mg (microscopic amount), so I weighed out 40mg and melted it in DMSO 4-5 drops. Then I poured this into 4 ozs of ArboTrex (70/30 DMSO/Aloe). Saw it in other places on this site. Used red pill mix, which melted in the DMSO to provide a mixing quality agent and I have a wonderful pink skin cream with a pretty high concentration and it actually is a solvent that penetrates skin pretty quick. I have solar keratosis in a few spots on my hand and forehead, should see something in a few months. 

I am waiting on taking Rapa pills to get a baseline test to see if there is any absorption into the bloodstream from the DMSO. I would expect some if the molecule is small enough...

On over indulging, after seeing how small a few milligrams is and how potent this is  I want to be careful. A safe weight loss regimen is up to 25mg one time dose in 2 weeks, so even if we do get absorption, it would take the entire 4 oz of cream to get interesting....but, if I double up with absorption and low dose pills it may be too prolonged in my system and hit MTOR2, which I would like to avoid.  

I'll let you know my results as the data comes in. 

I've been reading these postings, some of them old, some of them recent, with interest.   I must say that that there are different concepts of what slowing down aging means, and people are arguing about methods, when in fact they are really arguing about the meaning.  Someone believes that slowing down aging means preventing the physical decline of muscle (sarcopenia) by taking HGH.  Someone else believes in slowing down aging at the molecular level by mimicking calorie reduction through Rapamycin , or by actually fasting.  I've always felt that if slowing down aging meant that I had to weight 140 pounds and not be able to pick up my grandchild off the floor, I probably did not want that for myself.   It does seem from all the research articles I've read that in order to accept a more youthful molecular makeup, you have to sacrifice the actual advantages of youth (e.g. strength, speed, food).   I don't think that either extreme is useful.   In my case, I am 64 years old, but my biological age is 10-15 years younger.  I attribute it to my being a weightlifter since I was 18, and not smoking, drinking excessively, or doing any drugs.   When much younger and thinking of becoming a professional bodybuilder I turned down steroids, and HGH, because I did not believe they were safe. And from the experience of friends over the years, I was probably correct in that assessment.  At 64, I have no high BP, no evidence of cardiovascular disease, no diabetes, no prostate problems, no ED, and only recently developed gray hairs.  I can do things at my age that people half my age wish they could do.  But 2 years ago, when I saw my HA1C creep up to 5.5, I started taking Metformin preventively, and I also started doing a modified 16-8 eating window.  So I'm not averse to trying things.   My point is that there are tradeoffs, and the goal should be to live longer with a reasonably youthful molecular makeup, while not having to be a weak, puny 140 lbs.  If that means sacrificing some years, I would be for that (but I realize not everyone may share my sentiment).