Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.)
Dr. Green, a very impressive individual, gave me my personal prescription for sirolimus. I have a very good PPO (Blue Cross/Blue Shield). I took it to CVS, the affiliated pharmacy, and got a great price of about $2.90/mg. (Remember, you are only going to take about 3-6 mg/week.) With a PPO you can probably do this also. CVS wants to meter it to you with a month's worth of doses at a time, but that's just how they do things. You still have access to the full quantity prescribed.
With the prescription from my vet for my dogs, I was forced to take to the open sea. Armed with only a prescription and no insurance, the picture is quite different, but you can still get a good price. Cutting to the chase, I ended up at Walmart. The prescription was for 90 mg - price $1440. But wait! after presenting a coupon downloaded from GoodRX (that's right, just anonymously downloaded and printed) - price $396!!!! As my vet remarked, that's a hell of a charge for not looking around first! ($4.40/mg is better than taking a risk buying online, in my opinion.) Costco is pretty close to that price. At CVS/RiteAid, etc., you will pay vastly more.
You can't touch the original drug rapamune (Pfizer) unless you are wealthy or go to Canada. The problem with the online pharmacies is that a lot of them are scams. Just because they have a website doesn't mean anything. At least check to see if they have a brick and mortar location. Example: At one point I was excited by the online infomercials and wanted to take NMN instead of NR; however, when I looked up the reputations of the suppliers only one was unsullied, and on further investigation their brick and mortar location turned out to be a residential dwelling!
FYI, more than one company makes sirolimus. From CVS the sirolimus was made by Greenstone, LLC, apparently a wholly owned subsidiary of Pfizer.
Hope that helps some people who are considering rapamycin but think it might be out of their reach. If you know a doctor, great, but if you don't a visit to Dr. Green is worth the trip, and I live in CA! (round trip less than $300) Do your homework first and you will learn a great deal.
I'm going to get another 1g sample from the Alibaba supplier and give the skin lotion a try... I don't think accurate measurement is all that important, Blagosklonny implies that Rap isn't toxic and most likely can't overdose on it as he references a case where a woman tried to unsuccessfully commit suicide by downing 100 1mg tablets with no effect. I think I'm just going to get a micro spoon and try to get a "pinch" in it Lol and just mix it up in the palm of my hand with my favorite face conditioning lotion and apply. Just not sure how frequent to apply it, I'll read the article and see what the protocol was for the study.
I just received my second order (same supplier as my first) ...10.48 grams... for ~$650 Canadian. At the price I was paying for "Rapamune" brand in the local pharmacy... over $100,000.00 Canadian. I had been a bit concerned about supply chains... anyway, it's happy in my freezer. As before, I'll compound it, take it (back to my 1mg per day dose) test my levels, and if they are the same as all of my initial tests at that dose, I'll assume it is the real deal. Of course they supplied a COA... but I no longer trust any supplier... but my confidence in the one I have used is growing.
Just received my 10 grams, awaiting some #5 capsules and capsule loading apparatus.
Skin cream: I looked up Dr. Green's site and he has been formulating his for his solar keratosis with 15mg/oz in Aquaphor cream. So I wanted something a little weaker and easier to work with so I used 10mg/oz, each tiny amount on my smallest stainless spoon is 3mg (microscopic amount), so I weighed out 40mg and melted it in DMSO 4-5 drops. Then I poured this into 4 ozs of ArboTrex (70/30 DMSO/Aloe). Saw it in other places on this site. Used red pill mix, which melted in the DMSO to provide a mixing quality agent and I have a wonderful pink skin cream with a pretty high concentration and it actually is a solvent that penetrates skin pretty quick. I have solar keratosis in a few spots on my hand and forehead, should see something in a few months.
I am waiting on taking Rapa pills to get a baseline test to see if there is any absorption into the bloodstream from the DMSO. I would expect some if the molecule is small enough...
On over indulging, after seeing how small a few milligrams is and how potent this is I want to be careful. A safe weight loss regimen is up to 25mg one time dose in 2 weeks, so even if we do get absorption, it would take the entire 4 oz of cream to get interesting....but, if I double up with absorption and low dose pills it may be too prolonged in my system and hit MTOR2, which I would like to avoid.
I'll let you know my results as the data comes in.
The home handyman's guide to using pure Rapamycin powder.
1. Weigh .1g Rapamycin.
2. Cut ends from 20 Splenda packets. Save packets. Empty contents into small round bottom glass bowl. (Dessert dish). Yields approx 20 G.
3. Add Rapamycin to Splenda bowl. Mix 3 minutes with kitchen electric mixer paddle chucked into a variable speed cordless drill. Use low speed.
4 .Weigh resulting contents. Divide by 20. Weigh out that amount 20 times placing each portion in one saved packet and seal each. Mix again after each 2 or 3 portions.
5. Yields 20 - .005 G doses to be used in Sunday morning coffee for the next 20 weeks.
Maybe a bit Redneck but it gets the job done. Your mileage may vary.
I've been reading these postings, some of them old, some of them recent, with interest. I must say that that there are different concepts of what slowing down aging means, and people are arguing about methods, when in fact they are really arguing about the meaning. Someone believes that slowing down aging means preventing the physical decline of muscle (sarcopenia) by taking HGH. Someone else believes in slowing down aging at the molecular level by mimicking calorie reduction through Rapamycin , or by actually fasting. I've always felt that if slowing down aging meant that I had to weight 140 pounds and not be able to pick up my grandchild off the floor, I probably did not want that for myself. It does seem from all the research articles I've read that in order to accept a more youthful molecular makeup, you have to sacrifice the actual advantages of youth (e.g. strength, speed, food). I don't think that either extreme is useful. In my case, I am 64 years old, but my biological age is 10-15 years younger. I attribute it to my being a weightlifter since I was 18, and not smoking, drinking excessively, or doing any drugs. When much younger and thinking of becoming a professional bodybuilder I turned down steroids, and HGH, because I did not believe they were safe. And from the experience of friends over the years, I was probably correct in that assessment. At 64, I have no high BP, no evidence of cardiovascular disease, no diabetes, no prostate problems, no ED, and only recently developed gray hairs. I can do things at my age that people half my age wish they could do. But 2 years ago, when I saw my HA1C creep up to 5.5, I started taking Metformin preventively, and I also started doing a modified 16-8 eating window. So I'm not averse to trying things. My point is that there are tradeoffs, and the goal should be to live longer with a reasonably youthful molecular makeup, while not having to be a weak, puny 140 lbs. If that means sacrificing some years, I would be for that (but I realize not everyone may share my sentiment).
Hello Van... well, there it is... "Average" Hematocrit is 45%, and yours is only 41.5%... although almost all "doctors" would tell you that's "okay", I am not a doctor but I have 20 years experience with feedback from people that have less than 45% Hematocrit, and they all feel the same... BY DEFINITION, it is still not called "anemia"... but you are very close to the definition of "anemia"... Look up "anemia" on Google, and you will see that anemia is associated with many other degenerative conditions.
To begin with, all of the NEURONS in your body need OXYGEN... And less oxygen, means some of those neurons suffer. You were born with all of your nervous system... but for various reasons, some of our neurons die... we lose them...
But you should avoid at all costs to lose neurons, because WE ARE our nervous system. As we lose neurons, we become slower, we lose memory, we lose abilities.
That particular lost neuron will never be alive again. And as we get older, we lose neurons for many reasons... perhaps by accidents, perhaps by poisons, perhaps because the circulatory system gets blocked up by sugar and so blood (and oxygen) does not reach certain neurons... goodbye, neurons. Neurons can be substituted
by other neurons, but every neuron has a "memory" and once that memory is lost,
another neuron might try to replace it, but it is never quite as good as before.
That is "normal Aging"...
But you don't want to be "normal". You want to be "abnormal"
you want to NOT lose neurons. And with low red blood cells, you WILL lose neurons.... slowly... but you have to try to not let it happen. Go see a
hematologist, ask him to help you to raise your red blood cells.
I have seen numerous cases of low hemoglobin in the elderly, including my grandmother and my father, and also elderly friends. The medical community seems to believe that because it's in the elderly, it's ok. In 1998, my grandmother, 89 yrs old at the time, was hospitalized with low hemoglobin and some dizziness. She was given a transfusion which bumped up her hemoglobin and made her dizziness better, but it made he breathing more difficult. As the days progressed and her hemoglobin dropped, her breathing would get better but her dizziness would return. She was put through all kinds of test to eliminate the usual causes of low hemoglobin but they could find nothing. She was transferred from one hospital to another. Meanwhile, they continued to give her transfusions every 3-4 days, with the same effects as explained before. Finally one day she became septic, probably due to her immune system being compromised because of the regular transfusions, few days later developed general organ failure and died. At our insistence, they did an autopsy and discovered two small lesions in her heart, each about 6 months old (which made me recollect an episode of radicular arm pain she had had for a while). In other words, she'd had 2 small heart attacks, which had probably left her with congestive heart failure, which most likely was causing a bone marrow insufficiency leading to low rbc/hemoglobin. My father has also been living with low hemoglobin for 3 years (12.7 g/dL), and I can't seem to be able to convince anyone to treat it with Erythropoietin (I realize it's expensive). "Coincidently", during the last 3 years he developed MCI and now AD. I do wonder if anemia is incidental to AD. It can certainly make matters worse.
Thank you. But it's very difficult to get a doctor to think outside the conventional box. Treatment of anemia associated with CKD (renal insufficiency) is acceptable. But his renal functions are pretty good. I'm actually trying, but so far have failed to convince my father's GP to use erythropoeitin to treat his anemia. I also asked a geriatrics doctor, with the same results. His anemia is not considered serious enough, and the insurance company probably will not pay for the expensive treatment. But I will look over his medical history to see if T was tested. If it's low, I will probably run against the same resistance.
I just ordered fisetin looks like there are a couple of protocols, 1 gram per day for a few days or 500mg per day for 5 days. I'm going to try the 5 day one first.
Have made the rapa skin cream with arbotrex dmso product at 10mg per oz of cream. Works great on hands and arms, but too harsh for my face so I mixed up the same with a derma e hydrating face product which seems better. Only 2 weeks in on this and sore spots that were always festering have started to heal for the first time in years. Keratosis spots seem to be softening.. taking pics every week to document.
Took some rapa the last two weeks started low 3mg. Will continue for a month or two and increase probably to 5mg per week. Wife got some extra energy, me no difference yet.
Thank you all for the various suggestions. Let me mention that my father has been tested for all possible (known) causes of his very mild anemia, and all proved negative. No Iron deficiency, no B12/Folate deficiency, no malignancies,..etc. It does not seem wise to me to further burden his frail system by having him donate blood in order dilute his plasma. It would worsen his anemia, and the body will not be able to reconstitute his blood quickly enough. In a younger person it might make sense though. His GP has told me to take him to a Hematologist or Kidney specialist if I want him to be treated with Erythropoeitin. About Fisetin...I've been taking 200mg daily for 8 years as a preventive. Since late onset Alzheimer's seems to run in my father's family, I am concerned about it so I myself take it, and I've been giving it to him for about 3 years. R Alpha Lipoic Acid (600mg daily) and D3 (5000 IU or enough to boost levels above 50,000) are also part of our staple. In addition, I've had very good results recommending Benfotiamine to my father and friends who suffered from T2DM peripheral neuropathy. Their neuropathy completely resolved after several months of administration. In my opinion it works better than the other recommended regimen, B12/Folate. One particular friend, who's had T2DM for 30 years, was on his last legs (no pun intended) with foot pain and numbness caused by neuropathy. 6 months of Benfotiamine administration completely resolved it. And now I see it is in clinical trials for Alzheimer's also. I will say one other thing concerning Alzheimer's, if anyone is concerned about it. I was suffering from slight memory issues a few years ago, and also issues with concentration. I discovered a brain game called Double Decision, from Posit Science, which exercises memory and peripheral vision, and it did wonders for me. I've been using it for 4 years. It is the only cognitive training proven to reduce the incidence of Alzheimer's by so much (50%). NO ther brain game or cognitive training has proven it can do this. BTW, I am not connected in any way or benefit financially from recommending this, in case anyone wonders. I am including a link to the research in case anyone is interested.
The aggressive Rapa cream is working great on my Hands, Arms and the non DMSO product is helping on the face, but not as fast, as expected. Looks like even hard solar keratosis is going to be healed within 2-3 months, which is better than Retin A which I tried for 5 years!
Took the Fisetin, did not get any reactions, but have been on Resveratrol for a couple years, did up to 5 day water fasting, so that probably already took care of those old cells.
Taking the Rapa weekly, feeling OK, some up and down days as usual, but need to increase weight lifting again....to minimize sarcopenia.
I wanted to post an update from my original post here:
I have been taking weekly Rapamycin for 3 months now and I am very satisfied with what it is doing for me and how it makes me feel. In general, my weekly dose of Rap helps me get a much better night of sleep, it evens out the peaks and troughs of energy for me throughout the day (no cat naps needed anymore), more endurance of energy into the evening, better recovery after strenuous work or exercise, increase in mental sharpness/clarity, and an increase in motivation to get things done (daily tasks, projects, etc.)
First task was to determine my ideal dose, so I started with 5mg per week, and increased this 1mg at a time each week, I did this up through 13 mg... I weigh 79 kg so this peak dose is 0.165 mg/kg below the max of 0.2 mg/kg I was willing to push it... each week I would look for the side effects listed in the 2014 Manick paper, I never did get mouth ulcerations but at 9mg and higher I would get a headache a few hours after taking the weekly dose (I rarely get headaches)... headaches and mouth ulceration are the most frequent side effects listed by Manick... Now I have settled on 7 mg per week (0.088 mg/kg) and may go to 8mg, and no side effects are occurring, except for one...
I found that the weekly Rap was increasing my blood pressure, this is a result found in several studies (seems that almost 40% have experienced this)... my usual blood pressure is 125/82, but with the weekly dose it got as high as 150/90, enough of a concern for me to stop taking Rap for a week to see if my BP would return to normal, which it did. Further research seems to indicate that over the first 6 months to a 1 year BP will return to normal for most. I am monitoring my BP a few times per week, and willing to take the next year to see if it returns to my normal levels, the benefits of Rap are worth it as far as I am concerned! When I went off the Rap for a week I could really feel the difference of not having it, if you are taking Rap now take a week off and see how it makes you feel not to have it. I would say it took about 2 months for me to start noticing the benefits of the weekly Rap.
I also made some Rap skin lotion to treat my face and hands (on Dr. Green's website he gives instructions on how to do this)... Face for age spots and wrinkles, hands for sun/age spot. I mixed up a 0.002% and 0.02% mixture and use the 0.002% 4 times a week or so as an after shave, and the 0.02% 2 or 3 times per week for trouble spots... I have been doing this for a few months and I can see a difference in some wrinkles smoothing out, and the age/sun spots lightening... I will continue to apply the lotions over the next year and monitor results.
Thanks to everyone for sharing their Rap experiences and insights.
This is a new protocol of NAD replacement therapy especially for people over 65 yo. I believe this one will really work and is not expensive to try. 2-4 weeks, and should feel better, and have more endurance. How does this relate to Rapa? Well Rapa slows down NAD degeneration, but cannot replace it. I feel very good about the science behind this one. Dr. Green's senescence protocol is different, and should still be followed. Clear out those zombie's and replace NAD for increased well being and endurance. Only time will tell, but I will start tomorrow on mine and will give feedback. See Post #1739 https://www.longecity.org/forum/topic/94224-manipulating-mitochondrial-dynamics/page-58
Greetings folks, very occasional and intermittent lurker, first time poster.
I finally decided to pull the trigger on rapamycin powder, and now when I go to Alibaba there are zero hits for it or sirolimus. Wondering if it was a US thing, I opened a new private browser window and set my shipping destination to Mexico. Still no luck. Anyone else seen/is aware of this and no the reason? Is it still possible to source rapamycin powder?
Suggestions welcome. Thanks!
Accenture Biotech Co.,Ltd
Tel : 86-029-86230510
Add: Taoyuan North Road 355 ,Lianhu District ,Xi’an
I received 4 g from these guys about a month ago. Trusting them on the purity.
Looks like big pharma is shutting down Alibaba for sourcing our meds... the vendors their will still ship but the transaction can't be done through Alibaba, I rushed in an order for 5 years worth of Rapa and hope it keeps in the freezer Lol
Update: I think my last post 3 months ago or so I reported that the weekly Rapa was giving me high blood pressure 157/90... I did some research and found that some do experience this but within 6 months to a year BP levels return to normal for most... I was at the doctors office a few weeks ago to try and get a covid mask waiver for work, and my blood pressure was 118/75, that is the lowest reading I can ever remember! So looks like the BP is fine now...
thank God for the blessing of Rapamycin. Carry on peeps :)
Check this site: https://www.made-in-china.com. My only chinese rapa provider, Wuhan Hengheda Pharm Co., sells it no more at Alibaba, but does sell it in this new site for 110$/gram, providing door to door shipping. Surprisingly, if I want to buy rapa from that very same provider, to pay for it they give me a link @Alibaba 😊. BTW, I am european.
Well, no reason other than it just seemed simpler for me... Your concern about stability is reasonable. You might have to do some reading... or discuss with a pharmacist. I am a simple man.. who prefers simple solutions... and powder to powder seemed simple...
J Biomol Screen
2003 Apr;8(2):205-9.doi: 10.1177/1087057103252617.
The effect of room-temperature storage on the stability of compounds in DMSO
- PMID: 12844442
- DOI: 10.1177/1087057103252617
The stability of approximately 7200 compounds stored as 20-mM DMSO solutions under ambient conditions was monitored for 1 year. Compound integrity was measured by flow injection analysis using positive and negative electrospray ionization mass spectrometry. Each sample was assessed at the beginning of the study, after 12 months of storage, and at a randomized time point between the initial and final time points of the study. The relationship between length of storage and the probability of observing the compound was described by a repeated-measures logistic regression model. The probability of observing the compound was 92% after 3 months of storage at room temperature, 83% after 6 months, and 52% after 1 year in DMSO. An acceptable limit for compound loss and corresponding maximum storage time for samples in DMSO can be determined based on these results.