Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.)
Dr. Green, a very impressive individual, gave me my personal prescription for sirolimus. I have a very good PPO (Blue Cross/Blue Shield). I took it to CVS, the affiliated pharmacy, and got a great price of about $2.90/mg. (Remember, you are only going to take about 3-6 mg/week.) With a PPO you can probably do this also. CVS wants to meter it to you with a month's worth of doses at a time, but that's just how they do things. You still have access to the full quantity prescribed.
With the prescription from my vet for my dogs, I was forced to take to the open sea. Armed with only a prescription and no insurance, the picture is quite different, but you can still get a good price. Cutting to the chase, I ended up at Walmart. The prescription was for 90 mg - price $1440. But wait! after presenting a coupon downloaded from GoodRX (that's right, just anonymously downloaded and printed) - price $396!!!! As my vet remarked, that's a hell of a charge for not looking around first! ($4.40/mg is better than taking a risk buying online, in my opinion.) Costco is pretty close to that price. At CVS/RiteAid, etc., you will pay vastly more.
You can't touch the original drug rapamune (Pfizer) unless you are wealthy or go to Canada. The problem with the online pharmacies is that a lot of them are scams. Just because they have a website doesn't mean anything. At least check to see if they have a brick and mortar location. Example: At one point I was excited by the online infomercials and wanted to take NMN instead of NR; however, when I looked up the reputations of the suppliers only one was unsullied, and on further investigation their brick and mortar location turned out to be a residential dwelling!
FYI, more than one company makes sirolimus. From CVS the sirolimus was made by Greenstone, LLC, apparently a wholly owned subsidiary of Pfizer.
Hope that helps some people who are considering rapamycin but think it might be out of their reach. If you know a doctor, great, but if you don't a visit to Dr. Green is worth the trip, and I live in CA! (round trip less than $300) Do your homework first and you will learn a great deal.
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Dear all, I have an offer for 10g pure Sirolimus for 80USD incl. shipping to Germany from Henan Dongyao International Trade Co., Ltd. company looks like most others, did not find it on any black list. is the price too good to be true. they also let me pay by credit card. any thoughts much appreciated. also, if anyone in Germany wants some of it, pls let me know, 10g is too much....Thanks!
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News: Just paid using PayPal to Zhejiang Multinpharma Co., Ltd. for 10g Sirolimus and also ordered 1g Dasatinib. They sent CoA for Sirolimus (production date 16 Aug 21 - 2 year shelf life until AUG 23), I did not ask for one for the Dasatinib. Very good communication and paying by PayPal is super convenient. Thanks again chuck stanley for the tip! Fingers crossed for the shipment...
Any ideas about how to properly dilute and store Dasatinib?
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I started on Rapamycin January 2021. To truly understand/monitor/optimize the peak concentration and total AUC of dosing regiment, I studied the blood concentration kinetics literature, and designed a multi time point draw Sirolimus blood test 2 months ago. As you can see from attached graph, the peak is within 1-2 hours of consuming. From the paper, "whole blood concentrations reached a peak between 1 and 2 hours after Sirolimus dose administration". The study used an oral Sirolimus mixture, but other studies with traditional tablets reported similar kinetics. My Rapamycin was sourced in 4mg capsules. I followed the GFJ protocol for the experiment (waited 45 minutes after AM GFJ consumption before taking dose). I drew blood at time zero (pre-dose), then consumed dose (8mg), then drew blood every 30 minutes for 2 hrs. Unfortunately, my results did not produce any signal above 2 ug/L in any of the draws. I am still in the process of understanding the results of this experiment, including the veracity of the origin Rapamycin.
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Extremely helpful exchange of information on the compounding of rapamycin powder. Thanks Van, also Chris and SD…. Here is my revised plan:
1. 10 grams rapamycin (on the way) from Rainbow. Add a tiny bit of red dye #3 to the rapa, and triturate with 1000 grams of Rx grade lactose.
2. Weigh out 100g portions of mix, place portions into ten ziplock bags. Bags will be stored together in a larger quart freezer bag and a couple of color- changing desiccant packs for long term frozen storage.
3. Divide one of the 100g bags into five 20g bags, also to be contained in freezer bag for long term frozen storage.
4. Empty one of the 20g bags into a small plastic cup with a lid. Once I determine what size scoop holds the amount of mix that I want, I will scoop directly from this cup weekly, swallow and chase with water.
5. The cup will be stored at room temp inside a dark closed container with a gel pack desiccant.
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People buying rapamycin powder from china and not getting it lab tested for purity, and contaminants may want to read this article and see the test results from on Valisure lab analysis of rapamycin from Biocon and Zydus at the bottom of this page:
https://www.rapamycin.news/t/why-and-how-to-test-your-rapamycin-pt2/66
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If we could recruit a few other participants, I would be willing to share in the cost of a lab test on my rapamycin sample from Zhejiang Multinpharma Co. Ltd and I’d pay in advance to someone who has the savvy and willingness to take the lead, select the lab and go about getting a test of their sample. Anybody else interested? Bart? Chris? John? Anyone else who might be considering the purchase?
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Has anybody checked out this US company as a source for rapamycin?
https://teamtlr.com/anti-aginglongevity-research/169-rapamycin-cas-no-53123-88-9.html#/amount-500mg
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Dear all, here is an update on my learning journey of ordering Sirolimus and dasatinib from a Chinese supplier (see earlier posts). The substances have arrived in Germany and are now stuck at customs (TNT is the transportation company). Now TNT wants me to fill out several forms where I need to declare the nature of the substances and their intended uses. And I need to provide a payment receipt from my account. None of this off course matches the documentation provided by the supplier. It looks like if you are ordering from Germany you may be out of luck. The Chinese supplier has been very nice and supportive throughout - they promised to provide me an alternative delivery free of charge if this one does not go through. More soon!
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My senior dog has been on Rapamycin for about a year. Since then, his early stage kidney disease has practically vanished, and he has so much energy!! He’s spunky and doing very well, but his Lipase Levels in blood tests have been steadily rising since on Rapamycin and is now in the hundreds. His Alk. Phos. is rising, too, also very high. This could be a complete coincidence. Anyone else have such an experience? My local vet started him on a very high dose of Rapamycin (3 mg. X 3 weekly), but I have now lowered that to half. Wondering if I should lower it any further. Otherwise, he shows no outward negative side-effects, and Rapamycin has been a completely positive experience for him. I wish I had his energy! Any thoughts on this would be greatly appreciated.
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Take into account "the most definitive role in dermatology for DMSO lies in its ability to act as an effective vehicle. It greatly enhances percutaneous penetration when used in combination with other substances. DMSO facilitates diffusion through the stratum corneum, triggers the formation of deposits in the dermis, and promotes transport into the local blood vessels" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460663/). Meaning that it will take pills' fillers, if dissolved by DMSO, past stratum corneum, into your local blood. Fillers are designed to get transformed into innocuous substances in your stomach or gut, not to get straight into you skin and blood vessels. Just my two cents.
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2 of 2 – reply to Jay’s question
Jay Orman asked Mark Thimineur: Do you have any thoughts on how an average guy can find a doctor who will provide a prescription for weekly rapamycin therapy? (continues . . .)
Under the direction of Bill Faloon, and with assistance and direction by Brian Delaney (President, Age Reversal Network) and Maximus Peto (our website and forum administrator) we will soon go live with a new concept Age Management Telehealth Physicians. I’m managing the operations.
As the name implies, client/patients have consultations with an experienced age management physician remotely via our telehealth video portal. Clients will have personalized age management therapy programs created for them. There will be exceptions, but in general we will follow Bill's stairstep approach to biological age control, which includes rapamycin.
After lengthy preparation, we are close to beginning.
If you are interested please go here to send us your information.