Where to buy rapamycin?

Violette Toulon Check the Amazon prices for generic on Amazon Pharmacy.  Amazon Prime members may get a very good discount. 

Violette Toulon Perhaps of interest: https://www.rapamycin.news/t/rapamycin-for-dogs-part-2/85

Jay Orman Yes - Amazon prime prices for Sirolimus (generic) are very good.  This is the best US source I think, if you have a prescription.

@Jay Orman  Of all the US retailers I compared (including the Goodrx pricing) I found the lowest price for metformin and sirolimus to be via Amazon as a Prime member. Unfortunately, Medly was too expensive- they quoted me $801.87 for sirolimus 2mg/60 day supply. Amazon costs $494.90 for the same rx. I worry about the safety of these generics, even if they're from a US pharmacy, which is why my choice would have been Medly. The latest contamination scare was with hydrochlorothiazide. Before that it was with Metformin. Who knows what else is contaminated with cancer causing chemicals.  This is my first time ordering these pharmaceuticals, and after exhaustive research on these forums I finally decided to START the regimen with a prescription from a doctor, but my goal is to find a safe, reliable source in India. I want the freedom to make my own decisions concerning my regimen. 

Brin Chikovski Yes, Amazon prime offers best price. For the products from India, it seems that Siromus by Zydus Cadila is the safest source. 

Diane R Wilson I think this is as close as you'll find: https://www.rapamycin.news/t/rapamycin-for-dogs-part-2/85

Diane R Wilson My cats didn’t get in either. I’m wondering if you were about to get your cat started on it and if so how is it going? I contacted Truvium Vet last week about the status of release and approval. No time soon- they said it’s in the regulators hands and they would be opening up additional clinical trials in “the coming years” but could not speculate as to how soon the next would begin.

Karina . Hi there Karina. Please let me know where you ordered your tablets from? Did you go generic or brand? I hesitate to buy generic. Also, I have read that the suggested dosage is 0.05-0.1mg/kg 3 times a week for 10 weeks. Does that sound correct? Thank you!!

Renee Ferrero Hi Renee! Rapamycin is marketed in Brazil by Pfizer under the Rapamune brand, and this is what we’ll be using. With all of the feline studies, one of which I was told has concluded and should publish results within the next year, I’ve seen that the drug is administered once a week for twelve weeks in the case of renal disease, six months for the HCM studies. But there is no available information regarding the dosage levels. His cardiologist has been looking into it and said the lowest dosage he’s seen used is 0.05mg/kg, which is what we’ll be starting in about a month’s time. He’ll be receiving regular blood and urine testing, and assuming no adverse effects are noticed we’ll gradually increase the dosage. He was diagnosed with hyperthyroidism and has developed clotting since he began treatment for the condition, so we’re waiting for him to stabilise and doing research in the meantime before commencing.

Renee Ferrero 

Renee Ferrero Hi Renee. We’re hoping that both conditions might see improvements. I heard back from TriviumVet, the study is being compiled and will be released in 2023. I live in Brazil, so am purchasing from one of our many pharmacy chains (I think I won’t need a prescription, if so I have medical doctors willing to supply me with one) and having it compounded into the correct dosages. I’m not sure where you live, but have you looked into the possibility of sourcing it locally? I know members of this forum tend to purchase from India, but I’ve read that purity levels vary wildly. And both of my vets were hesitant too, but after sharing my research and making clear my intent to seek this therapeutic intervention, as well as stating that I’d abide by their instructions and monitor all of his vital signs with frequent testing, they are now fully on board. (I did ask for referrals from other contacts though, just in case they refused.) I’d suggest speaking with her again, if you trust her as a clinician. And if she doesn’t wish to participate, then ask if she could recommend you to another veterinarian who might. Given the unknowns and the delicate nature of his conditions as well as his age, as a fellow pet parent I would advise you against doing this on your own.