KLOTHO and GABA for Brain Enhancement
There is an article in today's NY Times about the wonders of KLOTHO, a recently discovered brain hormone that, at least in mice, increases lifespan, wards off Alzheimer's, and increases mental acuity. Researchers are using gene manipulation to increase KLOTHO production in mice, with spectacular results.
A bit of internet research turned up a paper entitled "The anti-aging protein Klotho is induced by GABA therapy ...", which indicates that the dietary supplement GABA (GAMMA-AMINOBUTYRIC ACID) boosts the production of KLOTHO in mice.
On the basis of that, today we ordered four bottles of 60 x 750 mg GABA (maximum strength) from Swanson's for $4.79 a bottle. In a month or so, I'll report whether my brain feels "enhanced".
-
We had ordered four bottles of 60 x 750 mg GABA (maximum strength) from Swanson's for $4.79 a bottle. Pauline and I took 750 mg twice a day until we ran out. We didn't really notice any big effects on memory or mental sharpness, positive or negative. I haven't reordered yet, but I may do so soon.
-
Klotho is an exciting treatment option, though a lot needs to be learned about dosing. Too much may be risky, given that KL-VS homozygosity is associated with cognitive decline, smaller brain regions, and all-cause mortality. See for example:
https://link.springer.com/article/10.1007/s11682-018-9990-1
https://www.ahajournals.org/doi/10.1161/01.res.0000157171.04054.30
Brian