Rapamycin and Fatigue

Dorian_gray
3 yrs ago
4replies

Is it a common side effect? I've been experiencing more tiredness in the last few weeks than at any time previously. Not sure if it is further aging catching up with me or a possible side effect of 10mg of Rapa weekly. Hasn't affected daily activities, just push my way through it. Noticing reduced strength when doing squats and pushups also. Anyone else?

- MAC2
- 3 yrs ago
- Reported - view
From this paper on Rapamycin administration on a cohort of cancer patients, summary of side effects. Fatigue is very common, especially at higher effective dosing (eg. higher Sirolimus alone or if taken at lower doses with GFJ)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410974/pdf/nihms604208.pdf
- Fred_Cloud
- 3 yrs ago
- Reported - view
Are you starting out at 10mg as most start out at 6mg?

Too much autophagy can create fatigue, when I was combining spermidine and rapamycin, it was too much and caused fatigue.
- Staffan_Olsson
  
  3 yrs ago
  
  Reported - view
  Fred Cloud The first months when I started with spermidine it made me sleepy. Therefore I took it in the evenings and I defintely slept better. After a few months that effect was not so prominent anymore.
- Dorian_gray
- 3 yrs ago
- Reported - view
Thanks for the info. I'm going to drop it to 5mg for a couple months and see how it goes.