Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates.
What is the value of resveratrol as part of an age reversal supplement program?
One highly visible individual recommends Resveratrol that is:
98+% pure, from a legitimate seller.
Do you know of such a product?
Recommended dose is 1 teaspoon (1 gram) daily. Is that a good dose?
Johnny Adams
https://www.aginginterventionfoundation.org/AgingInterventionProgram.pdf
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JohnnyAdams I have seen this one recommended (I have no connection to this company). They claim 98% purity and highest bio-availability. Some have suggested that the highly visible individual may be using this brand although that individual has a policy of not publicly mentioning brands.
https://store.revgenetics.com/collections/all/products/m98-bulk-micronized-resveratrol
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I've been using the eSquared Nutrition 1000mg for a while, from Amazon, which is inexpensive. I don't know if it's any good, or whether the product is kept at the right temperature during shipment and storage. But, besides the expensive pharmaceutical grade products, I think they are all the same. What differs are their marketing slogans and unsubstantiated claims. I take resveratrol because David Sinclair says he does too. He knows better than I do. However, unlike him, I take it around noon. And, I add 50 mg of pterostilbene at 5 o'clock in the morning. Many reviews say that pterostilbene is equivalent to resveratrol, just more stable and potent. Others say these are completely different products. I gathered that taking both will not hurt me and increases my chances of getting all the benefits.
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In answer to a question, Sinclair mentions some scientific trials that establish the benefits of pterostilbene in combination with NR. Most often, he rather mentions the virtues of resveratrol in combination with NMN.
https://youtu.be/9nXop2lLDa4?t=2576
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Resveratrol Bioavailability?
A bit of literature search on resveratrol indicates that it has a serious bioavailability problem. If one takes ~1000 mg capsules orally, most of the resveratrol is broken down by the liver and the digestive system, and the concentration that actually gets into the bloodstream tops out at ~2.0 micromoles per milliliter. That is a tiny fraction of the concentrations that has shown beneficial effects in aging human cell cultures, so it's not likely to have much benefit. Apparently in-cheek or under-the tongue administration might be better (x16 more effective), but absorbing a whole gram of the powder under the tongue seems difficult and unpleasant. Once again as with other polyphenols, the path to improve bioavailabiity seem to be direct injection or rectal suppositories. Anyone want to try and report?
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Compared to resveratrol alone, combination with piperine was found to increase the degree of exposure to 229 percent, and the maximum levels in the blood by a whopping 1,544 percent. “Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol,” report the researchers.Aug 16, 2011
Resveratrol bioavailability boosted by piperine: Study
https://www.nutraingredients-usa.com › Article › 2011/08/16 › Resveratrol-b...
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I have taken Biotivia's trans resveratrol because they were the manufacturer for the resveratrol in many of the initial studies. It's not the sort of thing you can get from any source and expect efficacy. The RevGenetics stuff looks good.
Also note that too much bioavailability caused some serious side effects in people that shut down studies of high doses of resveratrol as a drug candidate, so more may not be better.
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Given that resveratrol is able to prevent rapamycin-induced activation of Akt signaling in both ERα-positve and TNBC cells,and co-treatment of cells with rapamycin and resveratrol was able to maintain the inhibition of the mTORC1/S6K1 signaling pathway [Alayev et al., 2014a,b] doesn't it make sense for anyone taking Rapamycin over a long period of time to make sure to take resveratrol as well? (also see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491987/ )