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Re: AB263 Navitoclax
One would want to be extremely careful with Navitoclax as it could cause thrombocytopenia. Another exciting possible application of that compound is as a general anti-fibrotic.…
- cacarr
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Whole genome sequencing for $700-750?
@Applied Extropy Indeed -- I would like to be *paid* for my genome:…
- cacarr
- 6 yrs ago
- General Discussion
- Reported - view
Re: Whole genome sequencing for $700-750?
I would probably wait for Veritas to run another sale.
- cacarr
- 6 yrs ago
- General Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@Ellie - I would not be surprised if senolytic cell ablation can cause some fatigue -- maybe proportionate to the quantity of cells undergoing apoptosis. Seems plausible.
- cacarr
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@Fred Yeganeh - As I understand it, Fisetin probably induces apoptosis (in cancer cells, senescent cells, and possibly persistent myofibroblasts) primarily by inhibiting antiapoptotic Bcl-2 family…
- cacarr
- 6 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@Rob8311 @Steve Harris For what it's worth, itchy dogs are quite regularly fed quercetin (no proper studies, but a plausible mechanism) -- which is very close to fisetin.
- cacarr
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Whole genome sequencing for $700-750?
@DanMcL said: so why isn't the glucose even better ... Perhaps you would benefit from a particularly low carbohydrate diet. Replace some carbs with plant-based fats.
- cacarr
- 6 yrs ago
- General Discussion
- Reported - view
Re: Need more emphasis on diet
General health is great. It's not age reversal.
- cacarr
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Fisetin ( + quercitin)

Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
- cacarr
- 6 yrs ago
- 63replies
- 3314
- 5
- Senolytics Discussion

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