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Re: LDL-C reduction with diet and supplements (no statins) Sadly the kneejerk statin reaction to LDL is part of the orthodoxy. I'm glad the video was useful to you!
- Ajax
- Ajax
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: enhancing NAD precursor effectiveness @Dorian Gray Looking at ApexBio's catalogue for centella asiatica shows they only seem to sell triterpene isolates . Anyway, it's an in-vitro study, so nothing is guaranteed here.
- Ajax
- Ajax
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: enhancing NAD precursor effectiveness @RobH A study that found centella asiatica to be a stronger telomerase activator than TA-65 (in vitro) came to my attention. Since centella asiatica (aka gotu kola) is a fairly cheap supplement…
- Ajax
- Ajax
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: enhancing NAD precursor effectiveness @RobH Given the reported stability of NMN, going with enteric capsules make a lot of sense to me. Sublingual avoids stomach acid too, but I guess it's worth mentioning that sublingual absorption has…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
enhancing NAD precursor effectiveness
Therapeutic doses of NR and NMN in studies are usually much larger than the suggested amount on the label. Chromadex NR studies usually use a gram or more of the stuff,…
- Ajax
- Ajax
- 1 yr ago
- 6 replies
- 280
- 3
- Self-Experimentation
Re: How to increase the bioavailability of Fisetin @DIANE B you're welcome!
- Ajax
- Ajax
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JOHN Yeah, both Eosinophils and Lymphocytes are toward the upper end of normal, though obviously things improved quite a bit since the first test. I'd expect any fisetin effect to be gone by the…
- Ajax
- Ajax
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @DIANE B I have no idea how much to downsize by either, since it depends on how much fisetin is absorbed by the liver, and how much fisetin can be absorbed sublingually.…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @DIANE B Sure, sublingual administration avoids the liver's first pass. The basics seems to support that fisetin could be taken sublingually; the molecular weight is less than 500 (286) and it has a…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Koo I was using a bit less than that - about a shot glass worth - so maybe 45ml. I don't see smaller amounts being used. Even at these amounts, it looks like the fisetin is suspended,…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Koo I'm glad you figured it out, and that my post was helpful!
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @John W Thanks for posting that. Lots of good info indeed! I was especially glad to read the toxicology section, though given the widespread lower-dose supplemental use of fisetin,…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JOHN one of the common side effects of another senolytic, dasatinib, is low WBC. It's probably the same for fisetin at critical doses; I believe the white blood cells are depleted due to dealing…
- Ajax
- Ajax
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: Reversing arteriosclerotic disease Check out Ivor Cummin's channel on youtube. He's is a spokesperson for the Irish Heart Disease Awareness charity, and all of his information is based on studies.…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JOHN I've been taking Tru Niagen (NR) which I order through amazon. My reasoning for using NR is because it's the most studied in humans, and overall cost.…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JOHN My mother is in her early 80s. It's hard for me to pinpoint any beneficial effects specifically to fisetin (aside from the disappearance of the scar and skin tags) because we've also been…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Mel Always a question people enjoy answering. 😉 I'm 110kg.
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Dan Nave I don't think it's clear that milk is problematic for fisetin delivery. Milk is used to increase the bio-availability of fat soluble vitamins (fortified milk),…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: LDL-C reduction with diet and supplements (no statins) If you haven't, I'd recommend checking out Ivor Cummin's youtube channel, regarding LDL and it's lack of predictive capability in coronary disease. Ivor isn't just a talking head spouting off…
- Ajax
- Ajax
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells I've done two courses of Fisetin treatment (I'm 50) along with my wife and aged mother, and we all saw fairly obvious symptoms of senolytic action. During the first round of treatment,…
- Ajax
- Ajax
- 1 yr ago
- 4
- Self-Experimentation
- Reported - view

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