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Re: Rapamycin - progress so far @David H Well thats odd because rapamycin acts on senescent cells too and contributes to some of the antiaging effect of rapamycin. It doesnt kill them like a senolytic,…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: My Journey To Reduce My Epigenetic Age @Jimmy2 I had a similar test result from mydnage. I was on gdf11, rapamycin for 9 months and AKG for a month and they said my dna age went up 3 years in a period of 9 months.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: My Journey To Reduce My Epigenetic Age @Jimmy2 Nice HDL ! How did you get it that high? Regarding your ferritin, have you been donating blood to get it to that level? Mine was 400 about 4 years ago before I started donating and bringing…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Assessing Biological Age
- Reported - view
Re: Rapamycin - progress so far @Van I like the big dose followed by a big break if you can tolerate it. Why not add days instead of subtracting mg. when you hit side effects? Alot of people say take as much as you can until you…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: is pevonedistat an unknown novel anti-aging drug? @JGC Agreed. It must have reversed his epigenetic methylation age. I cant think of anything else that would give you the system wide youth effects that you are experiencing.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @JGC Actually, there is no such thing as GMO wheat even available. I am sure they are working on it, but as of now, there is no genetically modified wheat currently commercialized anywhere in the…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? I am wondering how spermidine compares to rapamycin? Does it do the same thing, is it a substitute or replacement for rapamycin, or does it offer benefits that rapamycin doesnt?
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Longevity Achieved @Jonette Brook Are you his wife? After reading Chuck stanleys post, we know it was all spam. The same exact day your husband posted "longevity achieved" he set up his Egabiotech website called…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne One thing I do wonder about with dilution therapy is what happens to the persons GDF11 levels, it would certainly dilute and lower those too.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Dorian Gray Yes, scroll to the top of this page and read John's post.
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne Makes alot of sense and I agree there is definitely alot of other moving parts in this equation and not just tgfb-1 at work here and TPE would be the most optimal approach to flush…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne When you say the immune system popping back up or not sounds more like you are determining efficacy of TPE for auto-immune disorders versus efficacy of rejuvenation or aging reversal.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne My TGFb1 is 1616, I wonder how low it gets after plasma dilution. Maybe one could use it as a comparative marker for TPE versus plasma donation and see how close the two are.
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne Are you sure it would have negative effects or are you just concerned it might?
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne Speaking of TGF-beta, I ran across this Conboy paper that said the plasma dilution works mainly because it lowers TGF-beta and further states that the ratio of TGF-beta to oxytocin is…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne Not sure if you saw the story of the russians who diluted their plasma, they basically donated twice. "We have a lot of interesting results,…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne ok, I follow you now, that makes sense, thank you for bringing clarity to this. Well if donation is not equal, I think it does offer some degree of benefit and should be considered as…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne I looked up the Conboy protocol and there is no defined amount, it just says they are diluting half the plasma and replacing it. So average person has 5 liters of blood half of that…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne 4 TPE treatments with Dobri Kiprov?
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now @Lou Hawthorne Can you point me to your source that Dr Kiprov doing Conboy therapy takes out 3 liters of plasma at a time?
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Cell Death Mechanisms Behind D+Q and Fisetin Senolytics @Katy Weston You took too high of a starting dose. I have autoimmune problems too and small doses like 500mg of fisetin wrecked me. I felt horrible for a couple of days and then I felt better.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Cell Death Mechanisms Behind D+Q and Fisetin Senolytics @chuck stanley autophagy? That is not what senolytics do. Senolytics trigger apoptosis or cell death in senescent cells not autophagy.
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Longevity Achieved @Richard Brook I am not sure if it was simply a put down just be abusive. Their point was, what was the point of you posting that? No need to be cryptic, you arent talking to novices.…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @JGC Well thats fascinating to learn that they are suiciding from their own sasp. I was looking at some other papers and found this mention that when they tested various compounds like fisetin etc…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @JGC I should have clarified, I do believe that fisetin is also a senolytic and does kill senescent cells, but it also has senomorphic properties that also quiets some of the senescent cells which…
- Fred Cloud
- Fred_Cloud
- 3 yrs ago
- Senolytics Discussion
- Reported - view

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Fred Cloud

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Joined: Sat Aug 31 22:45:30 UTC 2019

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