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Re: Rapamycin - progress so far
@Maria Molè Thats a very low dose, I am surprised you are having side effects with it.
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Peter This is not to be confused with long term inflammation lowering. The paper is basically saying the therapeutic effect of plasma donation is triggered by temporarily lowering tgf-b and raising…
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Peter I have always thought that the plasma donation spaced 2 days apart should get you to the 50% mark, but who knows. Have you considered supplementing with oxytocin to boost the effectiveness a…
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Peter Conboy studies show you need to dilute plasma by 50% to trigger rejuvenation and that is what Kiprov is able to achieve. Plasma donation is less than 25% total plasma volume.…
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Chris M Sinclair recommends high dose fisetin and Quercetin daily? Thats crazy. Senolytics arent meant to be taken daily long term. They are supposed to be pulsed, once a month at most.…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
I think you need to do more frequent sessions. Dr Green takes dasatinib and fisetin every 2 weeks. I think that is a bit too frequent, but people report return of inflammation that the senolytics…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Sea squirts, mussels and longevity
@JGC It is very pricey. I am very curious about these plasmologens and may try it for a month to see what happens. If it works well there will be competitors and the price will come down.
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Sea squirts, mussels and longevity
@JGC Prodrome supplement has the highest plasmologens. https://prodrome.com
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Michael Look for a brand that uses Novusetin fisetin ingredient. Lately, I have been using Wellness resources brand on amazon because they were offering 250mg caps so you dont have to take as many…
- Fred_Cloud
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Peter H. Howe Great to hear. But even younger people using fisetin on this forum have been getting great results, like fairy8i8 who is 38 years old. I guess I should tell her to ignore all her…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Peter H. Howe Agreed Peter, there are many reports of positive effects from fisetin out there like yours. It really makes me wonder how people do research on substances.…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JOHN Agreed, I am not convinced either. There have been so many positive reports from taking fisetin as a senolytic and people are just going to ignore those and listen to the ITP instead? Bizarre.…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course?
@JGC Interesting. Have you considered doing monthly with at least the fisetin? I have seen many reports on fisetin users on here and other forums that notice a wearing off effect of fisetin after…
- Fred_Cloud
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: RIP Ellis Toussier
Very sad to hear Rest in peace my friend.
- Fred_Cloud
- 3 yrs ago
- 2
- General Discussion
- Reported - view
Re: Rapamycin and Fatigue
Are you starting out at 10mg as most start out at 6mg? Too much autophagy can create fatigue, when I was combining spermidine and rapamycin, it was too much and caused fatigue.
- Fred_Cloud
- 3 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Rejuvant?
@Dennis Bittner Yeah, 5 grams of plain akg is probably going to give you problems. So if you are going to go that high I would use the Arg-AKG or a mix.…
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Rejuvant?
@Dennis Bittner Or just take plain AKG, I used it for 9 months and reversed my methylation age 14 years. So it works just fine too. So you dont need to use a salt, unless it irritates your gut.
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Does anyone know how to get and deliver SS31?
Yeah, I googled it and found about 5 different brands and suppliers very quickly. Did you just not google it at all or what are you asking?
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: rapamycin cream
@Jared Yes, exactly, just grind it up real fine and you should be ok.
- Fred_Cloud
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: rapamycin cream
@Jared I used tablets for face cream, works fine.
- Fred_Cloud
- 3 yrs ago
- Rapamycin Discussion
- Reported - view
Re: A hypothesis about Senescent Cells
@John Hemming Probably why plasma dilution sparks rejuvenation because you are diluting those suppressive cytokines. Personally I am hitting senescent cells with foxo4-dri to stop SASP and then…
- Fred_Cloud
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@David McCallister Why take so much? 10mg a day should be plenty but 10 grams would be 1,000 times higher dose.
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@David McCallister I assume you actually mean milligrams not grams, right?
- Fred_Cloud
- 3 yrs ago
- General Discussion
- Reported - view
Re: KLOTHO and GABA for Brain Enhancement
@Vojtěch Filipi still going great, very happy with the results.
- Fred_Cloud
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Which would you pick, young plasma or plasma dilution?

They are both available now, if you had to pick one, which one would you pick? Conboy plasma dilution or Ambrosia type young plasma? Which do you think would be more effective or which would you…
- Fred_Cloud
- 3 yrs ago
- 4replies
- 117
- 1
- General Discussion

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