Sea squirts, mussels and longevity

https://neurosciencenews.com/aging-sea-squirts-20570/#:~:text=They%20found%20that%20the%20supplements,impairments%20in%20the%20aging%20brain.

As the article suggests, supplementing with plasmalogens may reverse signs of aging.

• Professor Lei Fu, the corresponding author of the study, says: “Our research suggests that plasmalogens may not just stop cognitive decline, but may reverse cognitive impairments in the aging brain. Additionally, aged mice fed with the plasmalogens grow new black hair that is thicker and glossier than aged mice not fed the supplement.

There is evidence from the long-lived mole rat.

https://pubmed.ncbi.nlm.nih.gov/18029129/

• Vinyl ether-linked phospholipids (plasmalogens) are higher in naked mole-rat tissues than in mice.

The recommendation for hyaluronic acid as a longevity supplement, is also based on the finding that HA is higher in mole rats than mice.

https://pubmed.ncbi.nlm.nih.gov/23783513/#:~:text=We%20found%20that%20naked%20mole,than%20human%20or%20mouse%20HA.

With regard to palsmalogens, there is  evidence that plasmalogens may be involved in the exceptional longevity of centenarians.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357979/

• Consequently, plasmalogens could have a modulatory effect on oxidative stress, lipid-derived inflammation and cell signalling mechanisms. Lipidomic studies reveal that ether lipids are inversely associated with genetic peroxisomal disorders, and also suggest that they are negatively associated with prevalent disease states such as obesity, prediabetes, type 2 diabetes mellitus, cardiovascular disease, cancer and Alzheimer disease, among others [14], [15], [16], [18], [19]. Notably, these pathological states share as common trait an increased oxidative stress, and a potential mechanistic role for plasmalogens.
• As a consequence of these multiple observations, it is plausible to postulate that deciphering why centenarians markedly delay or in several cases even avoid age-associated diseases can help us in better understanding the aging process and the pathogenesis of age-related diseases, and that in these processes ether lipids and particularly plasmalogens can be involved.

Plamoalogens have  been recommended as a means to prevent Alzheimer’s disease.

https://www.todaysgeriatricmedicine.com/archive/SO19p6.shtml

• There is, in fact, a commercial product for Alzheimer’s, with plasmalogens derived from scallops. It is exorbitantly priced for 1,000 mcg (I mg) of plasmalogens. It seems they shot themselves in the foot with their graphs of plasmalogen content of foods. You get 3 mg of plasmalogens from one gram of mussels. So taking two caps (500 mg) of green lipped New Zealand mussel powder should provide higher levels of plasmalogens than the commercial brand.